Protein Alignment DNAlig4 and lig3

DIOPT Version :9

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001025345.2
• Gene: lig3 / 563276
• ZFINID: ZDB-GENE-030131-8453
• Length: 1011
• Species: Danio rerio
• Alignment Length: 982
• Identity: 216/982 - (21%)
• Similarity: 355/982 - (36%)
• Gaps: 314/982 - (31%)

  Fly    10 KFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGA------SSFYS 68
            :||.:|:|         ||.|               ..:..:|.:..|....|:      ...|.
Zfish   264 EFRKLCAL---------VAEK---------------SGYNAKTEIVRDFLTKGSGGDKFRGDLYL 304

  Fly    69 VLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRD--YGDVVYSVLK 131
            .::|||||  ..::.|.|....:.:|:.|:|....|            :|.:|  .|||..:|
Zfish   305 TVKLLLPG--VVKNVYNLNDKQIVKLFSRILNCNQD------------DMVQDLEQGDVSETV-- 353

  Fly   132 PRCF------NPPSNLRLKEIHQM------LDTIANEDTEVKQQQLIRFTEQASPEEQKWLIRLL 184
             |.|      .|||...|..|.::      |..:..||.:  |.:|....::.:..:.|..|||:
Zfish   354 -RMFFEESKSFPPSAKSLLTIQEVDASLSRLSQLTKEDDQ--QAELQSIAKKCTGNDLKCYIRLV 415

  Fly   185 LKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRT--TDLDASSSKDSKAAVKFVNLN 247
            ...|.:..|.:.|...:.|.|.|.::...:||.|    .||.  ...|||:....:   |.:::.
Zfish   416 KHDLKINSGAKHILDAVDPNAYDAFKASRNLGDV----IDRVLRNQQDASNGTGPR---KILSIE 473

  Fly   248 -SVIRPFHQIRPMLCERFPGDIQELMQS--DVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTR 309
             |::.|   ::|||.|... .|:..|:.  :.:|.|.|.||||.|:|.:...|.|.||
Zfish   474 ASLMTP---VQPMLAEACK-SIEYAMKKCPNGMYSEIKYDGERVQVHKNGNHFSYFSR------- 527

  Fly   310 NFGHSYDHGTLTPKL-------RGLLP---LGLESIILDGEMMVWDTNKLRFREKGENTDVKSLK 364
                     :|.|.|       :..:|   .|..|:|||.|:::.||              |:.|
Zfish   528 ---------SLKPVLPHKVAHFKDFIPQAFAGGHSMILDAEVLLIDT--------------KTSK 569

  Fly   365 P----------EGSWQPCFV---VYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARK 416
            |          :.::|...|   |:|.:||||.||:|....:|...|...:||....:.....:.
Zfish   570 PLPFGTLGVHKKAAFQDAQVGLFVFDCIYFNGVSLMDKPLCERRKFLHDNMVEVPNRILFSEMKH 634

  Fly   417 IGSVQEFNELFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGA 479
            :....:..|:..:.:....||:|||.....|:||.|   .|.|.|.||: :|.:.: .|::::||
Zfish   635 VTRAPDLAEMITRVIREGLEGLVLKDIKGLYEPGKR---HWLKVKKDYLNEGAMADTADLVVLGA 696

  Fly   480 FYNRKRT--FVDSFLLGVLQPAP---------PGSSNRPEVFSIGVVANNTKQRGVL----NHTL 529
            ||.:...  .:.|||:|...|..         .|.      |...::....|...|:    :.:.
Zfish   697 FYGKGSNGGIMSSFLMGCYDPESRKWCTVTKCSGG------FDDAMLDRLQKDLDVIKIGKDPSK 755

  Fly   530 KPHWHDVVNEPPPLWFHYKPKERSGCPDLWI-EPQNSVILQVKAADLAPNGAFFTRKSLH----- 588
            .|.|..:|..      :|        ||..| :||.:.:.::       .||.|::..:|
Zfish   756 IPGWLKIVKN------YY--------PDFIIRDPQKAPVWEI-------TGAEFSKSEMHTADGI 799

  Fly   589 ---FPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRL 650
               |||....||||.|.....|::..:|       .:::|.....| ||.       .||:.:
Zfish   800 SIRFPRCTRMRDDKDWKTATNLQQLKEL-------YRISKENCDFE-VTA-------GPSKAN-- 847

  Fly   651 GLAVYEKRYDASTSASTSKLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFC 715
                   :.|.|:|...|           .||:...|:........|||         :.||...
Zfish   848 -------QNDKSSSGGES-----------GGSSPSASRGASTANKPKNG---------HTPKAKA 885

  Fly   716 IAGDETF-LVKRLILQQPRTCDIVRMEWLLRVCQKQELELKPRDLIAATEPLQQDLAECFDRHGD 779
            ...:.:. .|||.:..:.:....::.|   .|....:.:||.   :..|:|.|:
Zfish   886 AKTESSAPAVKRKLPAEKQDVKKIKTE---SVHSNGQSKLKS---VPTTDPKQE----------- 933

  Fly   780 SYTKDIANVEELQDLLQGIELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGD- 843
                     :.|.|:..|::|              .|.:.:.|       |..|..:|.:..||
Zfish   934 ---------KTLLDIFTGVKL--------------YLPESVKD-------FEKLRRYFLAYDGDL 968

  Fly   844 --EVAKLLFLQNGGRIVDDSDPQLNLGFICMSSDIDNDHFEHWLHNHSKLTTDKVLNSAWIHQCH 906
              |....|.....|:..|.|..|                         |:|      |.||.:|.
Zfish   969 VPEYDSALATHTLGQPEDGSSAQ-------------------------KVT------SNWIWECI 1002

  Fly   907 REGILLP 913
            |:..::|
Zfish  1003 RKRRVVP 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	46/206 (22%)
		dnl1	84..613	CDD:273147	146/596 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	65/242 (27%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	35/162 (22%)
		BRCT	668..745	CDD:214602	13/77 (17%)
lig3	NP_001025345.2	zf-PARP	95..178	CDD:279039
		DNA_ligase_A_N	263..428	CDD:282522	46/206 (22%)
		dnl1	317..829	CDD:273147	147/606 (24%)
		Adenylation_DNA_ligase_III	467..679	CDD:185712	65/251 (26%)
		OBF_DNA_ligase_III	685..823	CDD:153436	36/164 (22%)
		LIG3_BRCT	935..1006	CDD:293364	24/122 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820