Protein Alignment DNAlig4 and lig1

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001119860.1
• Gene: lig1 / 556995
• ZFINID: ZDB-GENE-110404-2
• Length: 1058
• Species: Danio rerio
• Alignment Length: 670
• Identity: 160/670 - (23%)
• Similarity: 259/670 - (38%)
• Gaps: 125/670 - (18%)

  Fly     9 IKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLL 73
            :.:..:...||||:.........|.|.::..|....             .|:|.....|..|..|
Zfish   429 VPYLAVARTFEKIEEDSGRLKNIETLSNFLRSVILL-------------SPDDLLCCVYLCLNQL 480

  Fly    74 LPGADTGRDTYGLQITALGR--LYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSV-LKPRCF 135
            .|...      ||:: .:|.  |...|.|......|.|:.:.:...   |.|.|..|. ...|..
Zfish   481 GPAYQ------GLEL-GIGETVLMKAVAQATGRQLDKIKAEAQEKG---DLGLVAESSRSNQRMM 535

  Fly   136 NPPSNL-------RLKEI-HQMLDTIANEDTEVKQQQLI--RFTEQASPEEQKWLIRLLLKSLGL 190
            ..|:||       :|||| |...::..|:..::.:...:  ||:      |.::::|.|...|.:
Zfish   536 FAPANLTAGGVFNKLKEIAHMSGNSAMNKKIDIIKGLFVACRFS------EARYIVRSLAGKLRI 594

  Fly   191 GIGEQKIFGVLH------PKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSV 249
            |:.||.:...|.      |..|:......|.|...: ..:|...|:..:....:...:..|.:::
Zfish   595 GLAEQSVLAALSQAVCLTPPGQEFPPAVLDAGKGMS-TENRRVFLEEKALILKQTYCEMPNYDAI 658

  Fly   250 I----------RPFH-------QIRPMLCE--RFPGDIQELMQSDVLYLETKMDGERFQLHI-DR 294
            |          .|.|       .:||||..  :..|::.:.........|.|.||||.|:|| :.
Zfish   659 IPVLLKEGIDELPNHCKLTPGVPLRPMLAHPTKGVGEVMKRFDEASFTCEYKYDGERAQIHILEN 723

  Fly   295 GRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPL----GLESIILDGEMMVWDTNKLRFR--- 352
            |.....|||..|.|..:          |.:...:|.    .:.|.:||.|.:.||..|.:.:
Zfish   724 GEVRIFSRNQEDNTSKY----------PDIISRIPQVKKESVRSCVLDSEAVAWDREKKQIQPFQ 778

  Fly   353 ----EKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMR 413
                .|.::.|...:|.    |.|...:||||.||:||:.....:|...|::..||:.|.....|
Zfish   779 VLTTRKRKDVDASEIKV----QVCVYAFDLLYLNGESLVREPLSKRRALLRESFVEKEGEFVFAR 839

  Fly   414 ARKIGSVQEFNELFQQALDSHAEGIVLK--KQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLI 476
            :....:.:...|..:|::....||:::|  ::.:.|:...| ...|.|.|.||::|:....|:.:
Zfish   840 SLDADNTETIAEFLEQSVRDSCEGLMVKTLEKHATYEIAKR-SHNWLKLKKDYLEGVGDTVDLCV 903

  Fly   477 IGAFYNR-KRT-FVDSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLNH--TLKPHWHDVV 537
            |||:..: ||. ....|||...      .....|..|:..:....|...:..|  .||.|   ::
Zfish   904 IGAYLGKGKRAGGYGGFLLACY------DEENEEFQSVCKIGTGFKDEDLEQHYNFLKEH---IL 959

  Fly   538 NEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADL-------APNGAFFTRK--SLHFPRTE 593
            .:|.|    |...::|..||:|:|...  :.:||.|||       |..|.....|  ||.|||..
Zfish   960 PKPRP----YYRVDQSAEPDVWLEAVQ--VWEVKCADLSLSPVYKAAMGLVDPEKGISLRFPRFL 1018

  Fly   594 MKRDDKTWSECMTLKEFNDL 613
            ..||||...:..|..:..||
Zfish  1019 RIRDDKKPEDATTGSQIADL 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	145/593 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	63/249 (25%)
		BRCT	670..760	CDD:469589
		BRCT_2	830..917	CDD:465186
lig1	NP_001119860.1	PTZ00121	<148..>397	CDD:173412
		PLN03113	301..1053	CDD:215584	160/670 (24%)