DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig4 and lig1

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001119860.1	Gene:	lig1 / 556995	ZFINID:	ZDB-GENE-110404-2	Length:	1058	Species:	Danio rerio

Alignment Length:	670	Identity:	160/670 - (23%)
Similarity:	259/670 - (38%)	Gaps:	125/670 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLL 73
            :.:..:...||||:.........|.|.::..|....             .|:|.....|..|..|
Zfish   429 VPYLAVARTFEKIEEDSGRLKNIETLSNFLRSVILL-------------SPDDLLCCVYLCLNQL 480

  Fly    74 LPGADTGRDTYGLQITALGR--LYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSV-LKPRCF 135
            .|...      ||:: .:|.  |...|.|......|.|:.:.:...   |.|.|..|. ...|..
Zfish   481 GPAYQ------GLEL-GIGETVLMKAVAQATGRQLDKIKAEAQEKG---DLGLVAESSRSNQRMM 535

  Fly   136 NPPSNL-------RLKEI-HQMLDTIANEDTEVKQQQLI--RFTEQASPEEQKWLIRLLLKSLGL 190
            ..|:||       :|||| |...::..|:..::.:...:  ||:      |.::::|.|...|.:
Zfish   536 FAPANLTAGGVFNKLKEIAHMSGNSAMNKKIDIIKGLFVACRFS------EARYIVRSLAGKLRI 594

  Fly   191 GIGEQKIFGVLH------PKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSV 249
            |:.||.:...|.      |..|:......|.|...: ..:|...|:..:....:...:..|.:::
Zfish   595 GLAEQSVLAALSQAVCLTPPGQEFPPAVLDAGKGMS-TENRRVFLEEKALILKQTYCEMPNYDAI 658

  Fly   250 I----------RPFH-------QIRPMLCE--RFPGDIQELMQSDVLYLETKMDGERFQLHI-DR 294
            |          .|.|       .:||||..  :..|::.:.........|.|.||||.|:|| :.
Zfish   659 IPVLLKEGIDELPNHCKLTPGVPLRPMLAHPTKGVGEVMKRFDEASFTCEYKYDGERAQIHILEN 723

  Fly   295 GRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPL----GLESIILDGEMMVWDTNKLRFR--- 352
            |.....|||..|.|..:          |.:...:|.    .:.|.:||.|.:.||..|.:.:
Zfish   724 GEVRIFSRNQEDNTSKY----------PDIISRIPQVKKESVRSCVLDSEAVAWDREKKQIQPFQ 778

  Fly   353 ----EKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMR 413
                .|.::.|...:|.    |.|...:||||.||:||:.....:|...|::..||:.|.....|
Zfish   779 VLTTRKRKDVDASEIKV----QVCVYAFDLLYLNGESLVREPLSKRRALLRESFVEKEGEFVFAR 839

  Fly   414 ARKIGSVQEFNELFQQALDSHAEGIVLK--KQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLI 476
            :....:.:...|..:|::....||:::|  ::.:.|:...| ...|.|.|.||::|:....|:.:
Zfish   840 SLDADNTETIAEFLEQSVRDSCEGLMVKTLEKHATYEIAKR-SHNWLKLKKDYLEGVGDTVDLCV 903

  Fly   477 IGAFYNR-KRT-FVDSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLNH--TLKPHWHDVV 537
            |||:..: ||. ....|||...      .....|..|:..:....|...:..|  .||.|   ::
Zfish   904 IGAYLGKGKRAGGYGGFLLACY------DEENEEFQSVCKIGTGFKDEDLEQHYNFLKEH---IL 959

  Fly   538 NEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADL-------APNGAFFTRK--SLHFPRTE 593
            .:|.|    |...::|..||:|:|...  :.:||.|||       |..|.....|  ||.|||..
Zfish   960 PKPRP----YYRVDQSAEPDVWLEAVQ--VWEVKCADLSLSPVYKAAMGLVDPEKGISLRFPRFL 1018

  Fly   594 MKRDDKTWSECMTLKEFNDL 613
            ..||||...:..|..:..||
Zfish  1019 RIRDDKKPEDATTGSQIADL 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	44/199 (22%)
		dnl1	84..613	CDD:273147	145/593 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	63/249 (25%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	41/150 (27%)
		BRCT	668..745	CDD:214602
lig1	NP_001119860.1	PLN03113	301..1053	CDD:215584	160/670 (24%)
		DNA_ligase_A_N	430..601	CDD:282522	44/199 (22%)
		Adenylation_DNA_ligase_I_Euk	673..891	CDD:185710	59/232 (25%)
		OBF_DNA_ligase_I	896..1041	CDD:153438	44/158 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820