Protein Alignment DNAlig4 and lig3

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: XP_012827218.2
• Gene: lig3 / 549105
• XenbaseID: XB-GENE-5788004
• Length: 982
• Species: Xenopus tropicalis
• Alignment Length: 897
• Identity: 196/897 - (21%)
• Similarity: 334/897 - (37%)
• Gaps: 247/897 - (27%)

  Fly    10 KFRDICSLFEKIKATQKVAN-KEEVLKSYYESFCRHRESFRRQTGLNNDQPEDG-ASSFYSVLRL 72
            :||.:|::.    |.|...| |.::::.:                |......|| ....|..::|
 Frog   229 EFRKLCAMV----AEQPSYNSKTQIIRDF----------------LTKGTSGDGFHGDTYLTVKL 273

  Fly    73 LLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRD--YGDVVYSVL----K 131
            ||||..  :..|.|....:.:.:.|:.....:            .|.||  .|||..:|.    :
 Frog   274 LLPGVI--KSVYNLNDKQIVKHFSRIFNCNQE------------EMVRDLEQGDVSETVRIFFEE 324

  Fly   132 PRCFNPPSN--LRLKEIHQMLDTIANEDTEVKQQQLIR-FTEQASPEEQKWLIRLLLKSLGLGIG 193
            .:||.|.|.  |.:.|:..:|..::....|..||.::. ...:.:..:.|.:|||:...|.:..|
 Frog   325 SKCFAPASKSLLTIHEVDDLLTKLSKMTKEEDQQNVLEDIAHRCTSNDLKCIIRLIKHDLKMNSG 389

  Fly   194 EQKIFGVLHPKAQDIYQRCSDLGHVCNLL---------ADRTTDLDASSSKDSKAAVKFVNLNSV 249
            .:.:...|.|.|.|.::...:||.|...:         ..||..:.|                |:
 Frog   390 AKHVLDALDPNAYDAFKASRNLGDVVERVLRNEQQAPGMKRTLSVQA----------------SL 438

  Fly   250 IRPFHQIRPMLCERFPGDIQELMQS--DVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFG 312
            :.|   ::|||.|... .|:..|:.  :.:|.|.|.||||.|:|.:...|.|.||
 Frog   439 MTP---VQPMLAEACK-SIEYAMKKCPNGMYAEIKYDGERVQVHKNGDHFSYFSR---------- 489

  Fly   313 HSYDHGTLTPKL-------RGLLPL---GLESIILDGEMMVWDTN--------KLRFREKGENTD 359
                  :|.|.|       :..:|.   |..|:|||.|:::.|||        .|...:|....|
 Frog   490 ------SLKPVLPHKVAHFKDFIPKAFPGGNSMILDAEVLLIDTNTGKPLPFGTLGVHKKAAFKD 548

  Fly   360 VKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFN 424
            .         ..|..|:|.:||||.||:|....:|...::..:||....:.....:.:....:..
 Frog   549 A---------NVCLFVFDCIYFNGVSLMDRPLSERRKFMRDNMVEIPNHILFSEMKHVTKASDLA 604

  Fly   425 ELFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGAFYNRKRT- 486
            ::..:.:....||:|||...|.|:||.|   .|.|.|.||: :|.:.: .|:.::||:|.:...
 Frog   605 DMITRVIREGLEGLVLKDLKSNYEPGKR---HWLKVKKDYLNEGAMADTADLAVLGAYYGKGANG 666

  Fly   487 -FVDSFLLGVLQP-------APPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHDV-VNEPP- 541
             .:..||:|...|       ....||...:.         |.||      |:...:.| :::.|
 Frog   667 GIMSIFLMGCYDPESQKWCTVTKCSSGYDDA---------TLQR------LQKELNMVKISKDPS 716

  Fly   542 --PLWFHYKPKERSGCPDLWI-EPQNSVILQVKAADLAPNGAFFTR-KSLHFPRTEMKRDDKTWS 602
              |.|...   .::..||..| :|:.:.|.::..|:.:...|.... .|:.|||....||||.|.
 Frog   717 KIPSWLKI---NKNYFPDFIIHDPKKAPIWEITGAEYSKAEAHTAAGLSIRFPRCTRFRDDKDWK 778

  Fly   603 ECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSAST 667
            ...||::..:|       .:|:|                    |:|...:.....:.:..:|.|:
 Frog   779 TATTLQQLKEL-------YRLSK--------------------EKSDFNITATSSQDEDGSSESS 816

  Fly   668 SKLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQP 732
            |:..:|.|....|||..:.||:.               |..:..|      |:|....:|...|
 Frog   817 SRENEGNSRQTASGSMVKKSKNA---------------PSKSPGK------DKTSESTKLPPPQ- 859

  Fly   733 RTCDIVRMEWLLRVCQKQEL---ELKPRDLIAATEPLQQDLAECFDRHGDSYTKD-IANVEELQD 793
                           :|:||   |.:........:..:..::|....:|.|..:. :|| :.|.|
 Frog   860 ---------------KKEELPKAEKRKSQTPKTVQSKKAKISETGHSNGHSIAQSPVAN-KTLLD 908

  Fly   794 LLQGIELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGDEV 845
            :..|::|...          :.|:|           |..|..:|.:..||.|
 Frog   909 IFTGVKLHIP----------STLDD-----------FAKLRRYFIAFDGDLV 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	138/583 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	64/237 (27%)
		BRCT	670..760	CDD:469589	17/92 (18%)
		BRCT_2	830..917	CDD:465186	6/16 (38%)
lig3	XP_012827218.2	zf-PARP	64..149	CDD:459887
		dnl1	282..791	CDD:273147	139/593 (23%)
		LIG3_BRCT	905..976	CDD:465260	12/56 (21%)