DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig4 and DNAlig3

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	204/856 - (23%)
Similarity:	334/856 - (39%)	Gaps:	228/856 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLLLP 75
            ||.||   ::|........|.|.|:.::|.....: .|:..|.|              .::.|:|
  Fly    36 FRRIC---DEIAGESSYLKKAERLQRFFEKGSSGK-GFKGDTVL--------------WVQFLIP 82

  Fly    76 GADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSV---------LK 131
            .|:  :..|.||..||.:|:.|:.     ::|.   |..:.::.:| |||..::         ||
  Fly    83 AAN--QRVYNLQNKALIKLFSRIF-----NADQ---QQMHLDLEQD-GDVSETLRKHFAASKKLK 136

  Fly   132 PRCFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLI-RFTEQASPEEQKWLIRLLLKSLGLGIGEQ 195
            |:   ..|.|.|:|:.:||..:.....|.:|..|: :...:|:..:.:..|||:...|.:....:
  Fly   137 PQ---KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARAR 198

  Fly   196 KIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASS-----SKDSKAAVKFVNLNSVIRPFHQ 255
            .|.....|.|...||...||..:....|.:.....|||     .|.|.:|::      |:.|
  Fly   199 HILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQ------VMTP--- 254

  Fly   256 IRPML---CERFPGDIQELMQSDV--LYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSY 315
            |.|||   |:    .:::..:...  ||.|.|.||||.|:|.....|.:       ::||.....
  Fly   255 ISPMLASPCK----SVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKF-------FSRNLKPVV 308

  Fly   316 DHGTLTPKLRGL-------LPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSW---- 369
            ||     |:|.|       .|.|.| :|||.|:::.|            ||..:|.|.||.
  Fly   309 DH-----KIRALKKYIPQAFPGGGE-MILDSEIILVD------------TDTGALLPFGSLGAHK 355

  Fly   370 -------QPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELF 427
                   ..|..|:|.:.::|:.|....:.:|...|::.|......:||..:..:.:.:|...:.
  Fly   356 KQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMT 420

  Fly   428 QQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGAFY--NRKRTFV 488
            .:.|.::.||:|||...|.||||.|   .|.|.|.||: .|.:.: .|::::||:|  .:|...:
  Fly   421 ARVLHANLEGVVLKSPTSTYQPGKR---NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTL 482

  Fly   489 DSFLLGVLQPAPPGSSNRPEVFSIGVVANN-TKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKER 552
            ..||:|...             :.|.:... ||....|:.......|..:         .|..||
  Fly   483 SIFLMGCYD-------------AFGRLWKTVTKVHSGLDDATNAEVHKSL---------IKLTER 525

  Fly   553 SGCPDL--WIEPQNSVILQVKAADLAP--------NGAFFTRKSLH--------FPRTEMKRDDK 599
            :....:  |:....|::..|.|.|  |        .||.||:...|        |||...:|.||
  Fly   526 ADANAIPSWLLCSKSLVPDVLAKD--PMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDK 588

  Fly   600 TWSECMTLKEFNDL----------------CG----------GPLAIKKLN------KRQLRL-- 630
            :..|...|....||                |.          .|...||||      .::|:.
  Fly   589 SAKEANDLAHLEDLFEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSN 653

  Fly   631 -----ED---VTTKRKQMR----MTPSERSRLGLAVY-------------EKRYDASTSASTS-- 668
                 ||   |.:|||:.:    ::||::   ||..:             |.:.|.....|||
  Fly   654 TGSDDEDGAPVLSKRKESKAIRSLSPSQK---GLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSK 715

  Fly   669 -KLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQP 732
             :||:||   :...:..:.|...:|:.: ::|||....|...| ..|....:|...:::|.....
  Fly   716 PQLFEGL---VAHFAMEKDSSKLMQQFS-QHGGCCTTEPQKAD-LVFYANTNEALDLEKLRTLYR 775

  Fly   733 RTCDIVRMEWL 743
            |:|..:.:.||
  Fly   776 RSCRHLNVSWL 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	45/195 (23%)
		dnl1	84..613	CDD:273147	147/589 (25%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	67/240 (28%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	34/159 (21%)
		BRCT	668..745	CDD:214602	19/79 (24%)
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	45/195 (23%)
		dnl1	88..604	CDD:273147	149/592 (25%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	68/252 (27%)
		OBF_DNA_ligase_III	460..598	CDD:153436	35/161 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750