DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig4 and LIG3

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	XP_005258027.1	Gene:	LIG3 / 3980	HGNCID:	6600	Length:	1018	Species:	Homo sapiens

Alignment Length:	805	Identity:	185/805 - (22%)
Similarity:	318/805 - (39%)	Gaps:	195/805 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KSYYESFC--RHRE----SFRRQTGLNNDQPE------------------DG-ASSFYSVLRLLL 74
            :|...|.|  ||::    .||:...:..|.|.                  || ....|..::|||
Human   256 RSLSSSKCDPRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLL 320

  Fly    75 PGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRD--YGDVVYSVL----KPR 133
            ||..  :..|.|....:.:|:.|:.....|            :|.||  .|||..::.    :.:
Human   321 PGVI--KTVYNLNDKQIVKLFSRIFNCNPD------------DMARDLEQGDVSETIRVFFEQSK 371

  Fly   134 CFNP--PSNLRLKEIHQMLDTIANEDTEVKQQQLIR-FTEQASPEEQKWLIRLLLKSLGLGIGEQ 195
            .|.|  .|.|.::|:.:.|..::....|.:|||.:: ...:.:..:.|.:|||:...|.:..|.:
Human   372 SFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAK 436

  Fly   196 KIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPML 260
            .:...|.|.|.:.::...:|..|...:.....:::....:....:|:    .|::.|   ::|||
Human   437 HVLDALDPNAYEAFKASRNLQDVVERVLHNAQEVEKEPGQRRALSVQ----ASLMTP---VQPML 494

  Fly   261 CERFPGDIQELMQS--DVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLTPK 323
            .|... .::..|:.  :.::.|.|.||||.|:|.:...|.|.||                :|.|.
Human   495 AEACK-SVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSR----------------SLKPV 542

  Fly   324 L-------RGLLPL---GLESIILDGEMMVWD--TNK-LRFREKGENTDVKSLKPEGSWQP---C 372
            |       :..:|.   |..|:|||.|:::.|  |.| |.|...|       :..:.::|.   |
Human   543 LPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFGTLG-------VHKKAAFQDANVC 600

  Fly   373 FVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEG 437
            ..|:|.:|||..||:|....:|...|...:||....:.....:::....:..::..:.:....||
Human   601 LFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEG 665

  Fly   438 IVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGAFYNR--KRTFVDSFLLGVLQP 498
            :|||.....|:||.|   .|.|.|.||: :|.:.: .|::::||||.:  |...:..||:|...
Human   666 LVLKDVKGTYEPGKR---HWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYD- 726

  Fly   499 APPGSSNRPEVFSIGVVANNTKQRGVLNH---TLKPHWHDV----VNEPP---PLW-----FHYK 548
              |||.....|         ||..|  .|   ||....:::    :::.|   |.|     .:|
Human   727 --PGSQKWCTV---------TKCAG--GHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYY- 777

  Fly   549 PKERSGCPDLWI-EPQNSVILQVKAADLAPNGAFFTRK-SLHFPRTEMKRDDKTWSECMTLKEFN 611
                   ||..: :|:.:.:.::..|:.:.:.|..... |:.|||....||||.|.....|.:..
Human   778 -------PDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLK 835

  Fly   612 DLCGGPLAIKKLNKRQLRL--------EDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTS 668
            :|       .:|:|.:...        ...|....:....||     |.|| .::..:..||||.
Human   836 EL-------YQLSKEKADFTVVAGDEGSSTTGGSSEENKGPS-----GSAV-SRKAPSKPSASTK 887

  Fly   669 KLFDGLSFCILSGSAGRHSKHQL---------QELAVKNGGCIVENPLPNDPKCFCIAGDETFLV 724
            |. :|.    ||.|..:....|.         ::||.|:      :|:....|  ..|.|||...
Human   888 KA-EGK----LSNSNSKDGNMQTAKPSAMKVGEKLATKS------SPVKVGEK--RKAADETLCQ 939

  Fly   725 KRLILQ---------QPRTCDIVRM 740
            .:::|.         .|.|.|..|:
Human   940 TKVLLDIFTGVRLYLPPSTPDFSRL 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	44/195 (23%)
		dnl1	84..613	CDD:273147	135/576 (23%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	62/235 (26%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	37/157 (24%)
		BRCT	668..745	CDD:214602	20/91 (22%)
LIG3	XP_005258027.1	zf-PARP	106..188	CDD:279039
		DNA_ligase_A_N	273..438	CDD:282522	39/178 (22%)
		dnl1	327..839	CDD:273147	136/586 (23%)
		Adenylation_DNA_ligase_III	477..689	CDD:185712	62/245 (25%)
		OBF_DNA_ligase_III	695..833	CDD:153436	38/159 (24%)
		LIG3_BRCT	942..1013	CDD:293364	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820