DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNAlig4 and LIG1

DIOPT Version :10

Sequence 1:NP_572907.1 Gene:DNAlig4 / 32322 FlyBaseID:FBgn0030506 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_000225.1 Gene:LIG1 / 3978 HGNCID:6598 Length:919 Species:Homo sapiens


Alignment Length:511 Identity:125/511 - (24%)
Similarity:199/511 - (38%) Gaps:93/511 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 KQQQLIRFTEQASP----------------EEQKWLIRLLLKSLGLGIGEQKIFGVLH------P 203
            |.:.:.|.|..||.                .|.:::.|.|...|.||:.||.:...|.      |
Human   407 KFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTP 471

  Fly   204 KAQDIYQRCSDLGHVCNLLADRT----------------TDLDASSSKDSKAAVKFVNLNSVIRP 252
            ..|:......|.|......|.:|                .|||.......:..::.:..:..:.|
Human   472 PGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSP 536

  Fly   253 FHQIRPMLCERFPG--DIQELMQSDVLYLETKMDGERFQLH-IDRGRFMYISRNGVDYTRNFGHS 314
            ...::|||.....|  ::.:..:......|.|.||:|.|:| ::.|.....|||..|   |.|..
Human   537 GIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQED---NTGKY 598

  Fly   315 YDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNKLRFR-------EKGENTDVKSLKPEGSWQPC 372
            .|..:..||::  || .:.|.|||.|.:.||..|.:.:       .|.:..|...::.    |.|
Human   599 PDIISRIPKIK--LP-SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQV----QVC 656

  Fly   373 FVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEG 437
            ...:||:|.||:||:.....:|...|::..||..|......:.....:::..|..:|::....||
Human   657 LYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEG 721

  Fly   438 IVLK--KQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNR-KRT-FVDSFLLGVLQP 498
            :::|  ...:.|:...| ...|.|.|.||:.|:....|:::|||:..| ||. ....|||.... 
Human   722 LMVKTLDVDATYEIAKR-SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYD- 784

  Fly   499 APPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHD----VVNEPPPLWFHYKPKERSGCPDLW 559
              ..|.....:..:|.        |..:..|:.|...    |:..|.|    |...:.:..||.|
Human   785 --EDSEELQAICKLGT--------GFSDEELEEHHQSLKALVLPSPRP----YVRIDGAVIPDHW 835

  Fly   560 IEPQNSVILQVKAADL-------APNGAFFTRK--SLHFPRTEMKRDDKTWSECMT 606
            ::|  |.:.:||.|||       |..|...:.|  ||.|||....|:||...:..|
Human   836 LDP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATT 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNAlig4NP_572907.1 dnl1 84..613 CDD:273147 125/511 (24%)
Adenylation_DNA_ligase_IV 249..466 CDD:185713 60/228 (26%)
BRCT 670..760 CDD:469589
BRCT_2 830..917 CDD:465186
LIG1NP_000225.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..270
PspC_subgroup_1 <12..>285 CDD:468201
PLN03113 164..914 CDD:215584 125/511 (24%)
Interaction with target DNA 449..458 4/8 (50%)
Interaction with target DNA 642..644 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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