DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNAlig4 and LIG1

DIOPT Version :9

Sequence 1:NP_572907.1 Gene:DNAlig4 / 32322 FlyBaseID:FBgn0030506 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_000225.1 Gene:LIG1 / 3978 HGNCID:6598 Length:919 Species:Homo sapiens


Alignment Length:511 Identity:125/511 - (24%)
Similarity:199/511 - (38%) Gaps:93/511 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 KQQQLIRFTEQASP----------------EEQKWLIRLLLKSLGLGIGEQKIFGVLH------P 203
            |.:.:.|.|..||.                .|.:::.|.|...|.||:.||.:...|.      |
Human   407 KFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTP 471

  Fly   204 KAQDIYQRCSDLGHVCNLLADRT----------------TDLDASSSKDSKAAVKFVNLNSVIRP 252
            ..|:......|.|......|.:|                .|||.......:..::.:..:..:.|
Human   472 PGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSP 536

  Fly   253 FHQIRPMLCERFPG--DIQELMQSDVLYLETKMDGERFQLH-IDRGRFMYISRNGVDYTRNFGHS 314
            ...::|||.....|  ::.:..:......|.|.||:|.|:| ::.|.....|||..|   |.|..
Human   537 GIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQED---NTGKY 598

  Fly   315 YDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNKLRFR-------EKGENTDVKSLKPEGSWQPC 372
            .|..:..||::  || .:.|.|||.|.:.||..|.:.:       .|.:..|...::.    |.|
Human   599 PDIISRIPKIK--LP-SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQV----QVC 656

  Fly   373 FVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEG 437
            ...:||:|.||:||:.....:|...|::..||..|......:.....:::..|..:|::....||
Human   657 LYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEG 721

  Fly   438 IVLK--KQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNR-KRT-FVDSFLLGVLQP 498
            :::|  ...:.|:...| ...|.|.|.||:.|:....|:::|||:..| ||. ....|||.... 
Human   722 LMVKTLDVDATYEIAKR-SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYD- 784

  Fly   499 APPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHD----VVNEPPPLWFHYKPKERSGCPDLW 559
              ..|.....:..:|.        |..:..|:.|...    |:..|.|    |...:.:..||.|
Human   785 --EDSEELQAICKLGT--------GFSDEELEEHHQSLKALVLPSPRP----YVRIDGAVIPDHW 835

  Fly   560 IEPQNSVILQVKAADL-------APNGAFFTRK--SLHFPRTEMKRDDKTWSECMT 606
            ::|  |.:.:||.|||       |..|...:.|  ||.|||....|:||...:..|
Human   836 LDP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATT 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNAlig4NP_572907.1 DNA_ligase_A_N 10..197 CDD:282522 13/51 (25%)
dnl1 84..613 CDD:273147 125/511 (24%)
Adenylation_DNA_ligase_IV 249..466 CDD:185713 60/228 (26%)
OBF_DNA_ligase_IV 469..607 CDD:153437 41/153 (27%)
BRCT 668..745 CDD:214602
LIG1NP_000225.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..270
DUF4045 <10..275 CDD:330572
CDC9 164..914 CDD:330238 125/511 (24%)
Interaction with target DNA 449..458 4/8 (50%)
Interaction with target DNA 642..644 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1793
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D274264at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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