Protein Alignment DNAlig4 and Lig4

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001099565.1
• Gene: Lig4 / 290907
• RGDID: 1304639
• Length: 911
• Species: Rattus norvegicus
• Alignment Length: 879
• Identity: 271/879 - (30%)
• Similarity: 445/879 - (50%)
• Gaps: 90/879 - (10%)

  Fly     5 IASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSV 69
            :|:.:.|.|:||..|:|:..:..|.|....|.:.:|:.:..::..:.   ..|.|:    |||..
  Rat    10 VAAHVPFADLCSTLERIQKGKDRAEKIRHFKEFLDSWRKFHDALHKN---KKDVPD----SFYPA 67

  Fly    70 LRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIR-LQHRNGNMYR----DYGDVVYSV 129
            :||:||..:..|..||::.|.|.:|||.:|.||.:..||.: |.:|..:..|    |:..:.|.|
  Rat    68 MRLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDAQKLLNYRTPSGARSDAGDFATIAYFV 132

  Fly   130 LKPRCFNPPSNLRLKEIHQMLDTIANEDT----EVKQQQLIRFTEQASPEEQKWLIRLLLKSLGL 190
            |||||....| |.:::::::||.:|:.::    ::.::.|::...|.|..|||||||:::|.|.|
  Rat   133 LKPRCLQKGS-LTIQKVNELLDLVASNNSGKRKDLVKKSLLQLITQCSALEQKWLIRMIIKDLKL 196

  Fly   191 GIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQ 255
            |:.:..|..:.|..|.:::...:||..||..|.|.:..|...|                |..|..
  Rat   197 GVSQHTILSIFHNDAVELHNVTTDLEKVCRQLHDPSVGLSDIS----------------ITLFSA 245

  Fly   256 IRPMLC-----ERFPGDIQELMQSDVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSY 315
            .||||.     ||    :::.|:....|:|||:||||.|:|.|...:.|.||||.:||..||.|.
  Rat   246 FRPMLAAVADVER----VEKDMKQQSFYIETKLDGERMQMHKDGALYRYFSRNGYNYTDQFGESP 306

  Fly   316 DHGTLTPKLRGLLPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSWQPCFVVYDLLY 380
            ..|:|||.:.......::..|||||||.::.....|.:||...|:|.:..:...|.|:.|:|:|.
  Rat   307 QEGSLTPFIHNAFKTDVQVCILDGEMMAYNPTTQTFMQKGVKFDIKRMVEDSDLQTCYCVFDVLM 371

  Fly   381 FNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKKQGS 445
            .|.:.|...|..:|...|........|.:::::..:..:.||..:....|:|...|||::|...|
  Rat   372 VNNKKLGRETLRKRYDILSSTFTPIQGRIEIVQKTQAQTKQEVVDALNDAIDKREEGIMVKHPLS 436

  Fly   446 RYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNR--KRTFVDSFLLGVLQPAPPGSSNRPE 508
            .|:|..| |.||.|.|.:|:.||:.|.|:||:|.::.:  :...:..||..|.:..|||  ::|.
  Rat   437 IYKPDKR-GEGWLKIKPEYVTGLMDELDLLIVGGYWGKGSRGGMMSHFLCAVAETPPPG--DKPS 498

  Fly   509 VFSIGVVANNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGC-------PDLWIEPQNSV 566
            ||       :|..|....:|:| ..:|:..:....|..::.|....|       |:::|||||||
  Rat   499 VF-------HTLCRVGSGYTMK-ELYDLGLKLAKYWKPFQRKSPPSCILCGTEKPEVYIEPQNSV 555

  Fly   567 ILQVKAADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCG---GPLAIKKLNKRQL 628
            |:|:|||::.|:..:.|..:|.|||.|..||||.|.:||||.:...|.|   |.||.|.|:..
  Rat   556 IVQIKAAEIVPSDMYKTGSTLRFPRIEKIRDDKEWHDCMTLDDLEQLRGKASGKLATKHLHIG-- 618

  Fly   629 RLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTSKLFDGLSFCILSGSAGRHSKHQLQE 693
              :|...:.|:.:.....:..:|:..:.|..:.|.....|.:|:.:.||::||..| :.|..|:.
  Rat   619 --DDDEPREKRRKPISKTKKTIGIIEHLKAPNLSNINKVSNVFEDVEFCVMSGLDG-YPKPDLEN 680

  Fly   694 LAVKNGGCIVENPLPNDPKCFC-IAGDETFLVKRLILQQPRTCDIVRMEWLLRVCQKQE--LELK 755
            ...:.||.||:||   .|..:| |||.|...|:.:|.....  |:|:.||||. |.|.:  :..:
  Rat   681 KIAEFGGYIVQNP---GPDTYCVIAGSENIRVRNIISSDRH--DVVKPEWLLE-CFKTKTCVPWQ 739

  Fly   756 PRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLLQGI----ELTADNVAGITASNLNAL 816
            ||.:|......:|..|..:|.:||||..| |::::|:::...|    :.|.:.:|.:.|.    |
  Rat   740 PRFMIHMCPSTKQHFAREYDCYGDSYFVD-ADLDQLKEVFLRIKPSEQQTPEEMAPVIAD----L 799

  Fly   817 EDQLLDGKKNLNMFRNLNAF--FYSPHGDEVAKL 848
            |.:.......|:|||:...:  .|:...|..:|:
  Rat   800 ECRYSWDHSPLSMFRHYTVYLDLYAVINDLSSKI 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	181/551 (33%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	75/221 (34%)
		BRCT	670..760	CDD:469589	32/92 (35%)
		BRCT_2	830..917	CDD:465186	5/21 (24%)
Lig4	NP_001099565.1	dnl1	81..602	CDD:273147	181/552 (33%)
		BRCT_DNA_ligase_IV_rpt1	658..745	CDD:349354	32/93 (34%)
		DNA_ligase_IV	750..782	CDD:463272	10/32 (31%)
		BRCT_DNA_ligase_IV_rpt2	813..900	CDD:349349	5/21 (24%)