Protein Alignment DNAlig4 and cdc17

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_593318.2
• Gene: cdc17 / 2541849
• PomBaseID: SPAC20G8.01
• Length: 768
• Species: Schizosaccharomyces pombe
• Alignment Length: 698
• Identity: 161/698 - (23%)
• Similarity: 271/698 - (38%)
• Gaps: 170/698 - (24%)

  Fly    11 FRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLLLP 75
            |.::...|.||:.|.|.....:::.:|:             .|:..|.|.|..:..|..:..|
pombe   149 FAEMVKAFTKIENTSKRLEIIDIMGTYF-------------FGILRDHPSDLLACVYLSINKL-- 198

  Fly    76 GADTGRDTYGLQI--------TALGRLYIRVLQLPTDSSDAIRLQ-HRNGNMYRDYGDVVY---- 127
                |.|..||::        .|:|....:.||       .|:|. |:.|    |.|.|..
pombe   199 ----GPDYSGLELGIGESIIMKAIGESTGQTLQ-------QIKLSFHKVG----DLGLVAQTSRQ 248

  Fly   128 ---SVLKPRCFNPPSNL-RLKEIHQMLDTIANEDTEVKQQQLIRFTEQASPEEQKWLIRLLLKSL 188
               ::.||.....|... .||:|.||   ..|:....|...:.|........|.|:|||.|...|
pombe   249 NQPTMFKPAALTIPFLFDSLKKIAQM---SGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKL 310

  Fly   189 GLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIR-- 251
            .|.:.|:.|...                     ||:.|....|..:.:..:....:....::|
pombe   311 RLQLAEKTILVA---------------------LANATAQYHADKNGEKLSQQDRIEGEQILRDV 354

  Fly   252 -----PFHQIRPMLCERFPGDIQELMQ------------------SDVL--------YLETKMDG 285
                 .:..|.|.|.|...|.::|..:                  |:||        ..|.|.||
pombe   355 YCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIPTKPMLAKPTKQISEVLNTFDQAAFTCEYKYDG 419

  Fly   286 ERFQLHI-DRGRFMYISRNGVDYTRNFGHSYDHGTLT------PKLRGLLPLGLESIILDGEMMV 343
            ||.|:|. :.|:|...|||    :.|....|...:::      |..|        |.|||.|.:.
pombe   420 ERAQVHFTEDGKFYVFSRN----SENMSVRYPDISVSVSKWKKPDAR--------SFILDCEAVG 472

  Fly   344 WDTNK---LRFRE----KGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKL 401
            ||.::   |.|::    |.::..:..:|.    :.|...:|:||.|||.||:....:|...|..:
pombe   473 WDRDENKILPFQKLATRKRKDVKIGDIKV----RACLFAFDILYLNGQPLLETPLNERRKLLYSM 533

  Fly   402 IVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKK-QG--SRYQPGVRLGGGWYKDKAD 463
            ....:|.....:.....|::...|..::::....||:::|. :|  |.|:|..| ...|.|.|.|
pombe   534 FQPSTGDFTFAKHSDQKSIESIEEFLEESVKDSCEGLMVKMLEGPDSHYEPSKR-SRHWLKVKKD 597

  Fly   464 YIKGLITEFDVLIIGAFYNR-KRTFV-DSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLN 526
            |:.|:....|:::|||:|.: |||.| .:||||...   |.:.....:..:|.        |...
pombe   598 YLSGVGDSLDLIVIGAYYGKGKRTSVYGAFLLGCYD---PDTETVQSICKLGT--------GFSE 651

  Fly   527 HTLKPHWHD----VVNEPPPLWFHYK-PKERSGCPDLWIEPQNSVILQVKAADLAPNGAF----- 581
            ..|:..::.    |:::....:.|.. |..:   ||:|.||:  .:.:|.||||:.:..:
pombe   652 EHLETFYNQLKDIVISKKKDFYAHSDVPAHQ---PDVWFEPK--YLWEVLAADLSLSPVYKAAIG 711

  Fly   582 FTRK----SLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNK 625
            :.::    ||.|||....|:||:|.:..|.::.::.....:|..:..|
pombe   712 YVQEDKGISLRFPRFIRIREDKSWEDATTSEQVSEFYRSQVAYSQKEK 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	144/611 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	65/266 (24%)
		BRCT	670..760	CDD:469589
		BRCT_2	830..917	CDD:465186
cdc17	NP_593318.2	PLN03113	20..751	CDD:215584	159/688 (23%)