Protein Alignment DNAlig4 and adl1

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_595345.1
• Gene: adl1 / 2541111
• PomBaseID: SPBC713.06
• Length: 774
• Species: Schizosaccharomyces pombe
• Alignment Length: 627
• Identity: 140/627 - (22%)
• Similarity: 248/627 - (39%)
• Gaps: 168/627 - (26%)

  Fly    81 RDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSV-LKPRCFNPPSNLRLK 144
            ::..|:..:||..|:                     |.|.|.|||.:.. :..|..:.|..|.:|
pombe   232 KEVCGITASALKNLW---------------------NKYGDPGDVAFEAKVSVRTLSRPEPLTIK 275

  Fly   145 EIHQMLDTIANEDTEVKQQQLIRFTE----QASPEEQKWLIRLLLKSLGLGIGEQKIFGVLHPKA 205
            :::..|..||:.:....|.:.:..|:    .::.||.:::.|.::::|.:|..:..:...| .||
pombe   276 KVYSTLLKIADSNGNGAQNRKLELTKFLLISSNAEEVRYIGRSIMQNLRIGAVQNTMLASL-SKA 339

  Fly   206 QDIYQRCSDLGHVCNLLAD------------------RTTDLDASSSKDSKAAVKFVNLNSVIRP 252
            ..|:...::   :.|..:|                  :..|.:...:...:..::.:..|..|||
pombe   340 FFIFDNQNE---IFNFNSDSLQQQFRQGEEIVKQSFFQVPDYNILVATLLREGIENLKDNMSIRP 401

  Fly   253 FHQIRPMLCERFPGDIQELMQSDVLYL-------ETKMDGERFQLHIDR-GRFMYISRNGVDYTR 309
            ...::|||     |.|.:.:|..:..|       |.|.||:|.|:|.|| |.....||:..:.|.
pombe   402 GIPVKPML-----GSITKNLQHMLERLTDHNFSCEFKYDGQRAQIHCDRLGNIKIFSRHLEEITG 461

  Fly   310 NFGHSYDHGTLTPKLRGLLPLGLE---SIILDGEMM--------VWDTNKLRFREKGENT----- 358
            .|          |.:..:..|.|:   ..|::||::        :.|..||..||:.:.|
pombe   462 RF----------PDVIEVAQLALKHSCDFIIEGELVAIDKSNGQILDFQKLSTRERKKVTVADIT 516

  Fly   359 -DVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVL----QLMRARKIG 418
             ||           |..|:|:::.:|:|.|....|:|    :::..|...::    |.:.:.:..
pombe   517 IDV-----------CVFVFDIMFCDGKSCLQMPLIER----RRMFFEHFNLIPNRFQFVSSLETN 566

  Fly   419 SVQEFNELFQQALDSHAEGIVLK-------KQGSRYQPGVRLGGGWYKDKADYIKGLITEF---D 473
            ..|...|.|..|:.:..||:::|       |..|.|:|..| |.||.|.|.||    ..||   |
pombe   567 EEQSIQEFFSLAITNKCEGLMVKVLNGTNSKFPSTYEPDKR-GEGWIKVKQDY----DDEFESLD 626

  Fly   474 VLIIGAFY--NRKRTFVDSFLLGVLQPAPPGS--------SNRPEVFSIGVVANNTKQRGVLNHT 528
            ::.|||:|  .||..:....||.|..| ..|:        |...:.|...:....:.:.|  |.:
pombe   627 LVPIGAWYGNGRKAGWFSPILLAVYNP-DTGAYEAVCKCMSGFSDQFYKELTQKYSLESG--NSS 688

  Fly   529 LKPHWH--DVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADLAPNGAFFTR------- 584
            |||.::  :.....|.::|  .|:|      :|         ::|.|.:..:.|:...
pombe   689 LKPIYNFCETGKVTPQIYF--APQE------VW---------EIKGAQITSSPAYKAALGLIQDD 736

  Fly   585 --KSLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLN 624
              .|:.|||....|.||...:..|.....|     :.:|:||
pombe   737 RGLSIRFPRFIRVRSDKGPEDASTNSILAD-----MYMKQLN 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	136/611 (22%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	67/252 (27%)
		BRCT	670..760	CDD:469589
		BRCT_2	830..917	CDD:465186
adl1	NP_595345.1	PLN03113	73..771	CDD:215584	137/623 (22%)