DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DNAlig4 and lig4

DIOPT Version :9

Sequence 1:NP_572907.1 Gene:DNAlig4 / 32322 FlyBaseID:FBgn0030506 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_587888.2 Gene:lig4 / 2539042 PomBaseID:SPCC1183.05c Length:913 Species:Schizosaccharomyces pombe


Alignment Length:994 Identity:251/994 - (25%)
Similarity:430/994 - (43%) Gaps:199/994 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASTIKFRD-ICSLFE---KIKATQ--KVAN------KEEVLKSYYESFCRHRESFRRQTGLNNDQ 58
            :||::|.| :.:|.|   :|..|:  |.:|      |.::|..|:..:.:|              
pombe    16 SSTLEFYDFVTTLLEPLSRIGKTRKSKTSNLDPYELKRKILLDYFNKWRQH-------------- 66

  Fly    59 PEDGASSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRDYG 123
               .....|.:|||:||..|..|.:||.:...||:|:||.:.|...|.||..|::..|:..:..|
pombe    67 ---VGPDLYPLLRLMLPDLDRERGSYGFKEFGLGKLFIRAMHLSPTSEDAKSLKNWRGSESKHTG 128

  Fly   124 D---VVYSVLKPRCFNP-PSNLRLKEIHQMLDTIA---NEDTEVKQQQLIRFTEQASPEEQKWLI 181
            |   ::..:|:.|.:.. |....:.:::.:||.:|   :|||.|  ..|.:|....||.|.:|||
pombe   129 DFSTMLQDILQRRAYRTFPGAFTVGDVNALLDQLADASSEDTRV--NILEQFYRSLSPLELRWLI 191

  Fly   182 RLLLKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNL 246
            .:|||....|..|:.|..|.||.|..:|:.||.|..:|..|.|.:..||.:.:.           
pombe   192 PILLKVRKYGTSEKFILSVFHPDAARLYRLCSSLKRICWELYDPSRSLDETETD----------- 245

  Fly   247 NSVIRPFHQIRPMLCERFPGDIQ---ELMQSDVLYLETKMDGERFQLHIDRGRFMYISRNGVDYT 308
               :..|...:|.|......|:.   |.|.:...::|.|:||||.|||:..|:|.:.|||...||
pombe   246 ---VEVFSCFQPQLANFKKKDLHQTLEAMGNKPFWIEEKLDGERIQLHMSSGKFQFYSRNARSYT 307

  Fly   309 RNFGHSY--DHGTLTPKLRGLLPLGLESIILDGEMMVWDT--------NKLR--FREKGENTDVK 361
            ..:|.||  :...||..:.|.....:..|||||||:.||.        ..||  |.:...::   
pombe   308 YAYGSSYFDEQSRLTQYIIGAFDKRISQIILDGEMVTWDPVLETVIPYGSLRSIFEDSSSHS--- 369

  Fly   362 SLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGS-VQEFNE 425
                  |:.|.:||:|:||.||:||:.::...|...|:|:||.:|..:.:: ..|:|| :::...
pombe   370 ------SYSPYYVVFDILYLNGKSLVKYSLESRRRILEKVIVRESHRMSIL-PYKVGSTIEDIEA 427

  Fly   426 LFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNRKRTF--V 488
            ..:..:...:||:|:||....|..|.|: ..|.|.|..|::|...:.|.||:|.::.|.:..  :
pombe   428 ELRNVIQEGSEGLVIKKPSGSYHLGERM-DDWIKVKPYYLQGFGEDLDCLILGGYFGRGKQSGKI 491

  Fly   489 DSFLLGV-LQPAPPGSSNRPEVFSIGVVANNTK-QRGVLNHTLKPHWHDVVNEPPPLWFHYKPKE 551
            :|||.|: :...|...|.:.:.| :.|....|. .|.::....:..|....::..........|:
pombe   492 NSFLCGLRMDYTPKDHSEKFQSF-VRVGGGFTYFDRDIIRKETEGKWLPWSSDALEYMELAGTKQ 555

  Fly   552 RSGCPDLWIEPQNSVILQVKAADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCGG 616
            ....||:||.|::|::||:|||::..:..|.|..:|.|||.|..|.|::|.:.:|:.||      
pombe   556 DFEKPDMWIHPKDSLVLQIKAAEVVVSNRFKTNYTLRFPRLEKVRLDRSWKDALTINEF------ 614

  Fly   617 PLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTSKLFDGLSFCILSG 681
             ..:|...::|   ::|:....:.|....:|.:....:|::......::..|.:...|.|.:|..
pombe   615 -FTLKNAVEKQ---DNVSFHVNKKRKVSQKREKQKKFLYDEPTFKKEASPHSDVLKNLHFVVLPP 675

  Fly   682 SAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLV-----KRLILQQPRT-CDIVRM 740
            :....:|..||::.::||| ::...:.|..|      :..|||     .|:.:::.:. |.|:|.
pombe   676 TELHETKAGLQQIIIENGG-LIHQGVGNFGK------ERLFLVADRVSTRVSIERSKNMCTIIRS 733

  Fly   741 EWLLRVCQKQEL----------------------ELKPRDLIAATEPLQQ-DLAECFDRHGDSYT 782
            :|::.....|.|                      .|..:.|......|:| ||::.:.:..|.  
pombe   734 QWVMDSVNNQRLMPQWSYLLFSKDEKYSWKTALESLSAKSLSNLLVELKQLDLSKEYSKISDD-- 796

  Fly   783 KDIANV----EELQDL-------------LQGIELTADNVAGITASNLNALEDQLLDGKKNLNMF 830
            ..|.|:    ||...:             |:|||                 ..:|.|.:  :..:
pombe   797 TSILNLTISKEEASFVGAFPFLKFTVFLDLKGIE-----------------NSELYDVR--MGQY 842

  Fly   831 RNLNAFFYSPHGDEVAKLLFLQNGGRI---------------VDDSDPQLNLGFICMSSDIDND- 879
            |             :.|.:.|.||..|               |:||.....|...|....|:.. 
pombe   843 R-------------LTKCILLWNGATIEKDISSKKLTHVVMFVEDSTRLEQLTKACELYQIEPKF 894

  Fly   880 -HFEHWLHNHSKLTTDKVL 897
             :|| |:.|..|..:..:|
pombe   895 VNFE-WVVNEWKKASTNIL 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNAlig4NP_572907.1 DNA_ligase_A_N 10..197 CDD:282522 58/205 (28%)
dnl1 84..613 CDD:273147 166/555 (30%)
Adenylation_DNA_ligase_IV 249..466 CDD:185713 72/232 (31%)
OBF_DNA_ligase_IV 469..607 CDD:153437 38/141 (27%)
BRCT 668..745 CDD:214602 20/82 (24%)
lig4NP_587888.2 DNA_ligase_A_N 20..207 CDD:282522 58/205 (28%)
dnl1 89..613 CDD:273147 164/551 (30%)
Adenylation_DNA_ligase_IV 242..467 CDD:185713 72/249 (29%)
OBF_DNA_ligase_IV 470..611 CDD:153437 38/141 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 108 1.000 Domainoid score I1649
eggNOG 1 0.900 - - E1_COG1793
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1736
Inparanoid 1 1.050 268 1.000 Inparanoid score I721
OMA 1 1.010 - - QHG54896
OrthoFinder 1 1.000 - - FOG0004767
OrthoInspector 1 1.000 - - oto101475
orthoMCL 1 0.900 - - OOG6_103257
Panther 1 1.100 - - LDO PTHR45997
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R326
SonicParanoid 1 1.000 - - X3920
TreeFam 1 0.960 - -
1413.860

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