DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig4 and Lig3

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	XP_006532410.1	Gene:	Lig3 / 16882	MGIID:	109152	Length:	1066	Species:	Mus musculus

Alignment Length:	985	Identity:	195/985 - (19%)
Similarity:	342/985 - (34%)	Gaps:	324/985 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDG-ASSFYSVLRLL 73
            :||.:|::   :........|.:::..:.:         :..||       || ....|..::||
Mouse   321 EFRKLCAM---VAENPSYNTKTQIIHDFLQ---------KGSTG-------DGFHGDVYLTVKLL 366

  Fly    74 LPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRD--YGDVVYSVL----KP 132
            |||..  :..|.|....:.:|:.|:.....|            :|.||  .|||..::.    :.
Mouse   367 LPGVI--KSVYNLNDKQIVKLFSRIFNCNPD------------DMARDLEQGDVSETIRIFFEQS 417

  Fly   133 RCFNP--PSNLRLKEIHQMLDTIANEDTEVKQQQLIR-FTEQASPEEQKWLIRLLLKSLGLGIGE 194
            :.|.|  .|.|.::|:...|..::....|.:|||.:: ...:.:..:.|.:|||:...|.:..|.
Mouse   418 KSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGA 482

  Fly   195 QKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPM 259
            :.:...|.|.|.:.::...:|..|...:.....:::....:.....|:    .|::.|   ::||
Mouse   483 KHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQ----ASLMTP---VQPM 540

  Fly   260 LCERFPGDIQELMQS--DVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLTP 322
            |.|... .|:..|:.  :.::.|.|.||||.|:|.....|.|.||                :|.|
Mouse   541 LAEACK-SIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSR----------------SLKP 588

  Fly   323 KL-------RGLLPL---GLESIILDGEMMVWDTN---KLRFREKGENTDVKSLKPEGSWQP--- 371
            .|       :..:|.   |.:|:|||.|:::.|.|   .|.|...|       :..:.::|.
Mouse   589 VLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLG-------VHKKAAFQDANV 646

  Fly   372 CFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAE 436
            |..|:|.:|||..||:|....:|...|...:||....:.....:::....:..::..:.:....|
Mouse   647 CLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLE 711

  Fly   437 GIVLKKQGSRYQPGVRLGGGWYKDKADYI-KGLITE-FDVLIIGAFYNR--KRTFVDSFLLGVLQ 497
            |:|||.....|:||.|   .|.|.|.||: :|.:.: .|::::||||.:  |...:..||:|...
Mouse   712 GLVLKDVKGTYEPGKR---HWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYD 773

  Fly   498 PAPPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHD---------------VVNEPP--PLW- 544
            |    .|.:        ....||..|         .||               :..:|.  |.|
Mouse   774 P----DSQK--------WCTVTKCAG---------GHDDATLARLQKELVMVKISKDPSKIPSWL 817

  Fly   545 ----FHYKPKERSGCPDLWI-EPQNSVILQVKAADLAPNGAFFTRKSLH--------FPRTEMKR 596
                .:|        ||..: :|:.:.:.::       .||.|:|...|        |||....|
Mouse   818 KINKIYY--------PDFIVPDPKKAAVWEI-------TGAEFSRSEAHTADGISIRFPRCTRIR 867

  Fly   597 DDKTWSECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDA 661
            |||.|.....|.:..:|            .||                 .:.:...||......:
Mouse   868 DDKDWKSATNLPQLKEL------------YQL-----------------SKDKADFAVVAGDEAS 903

  Fly   662 STSASTSKLFDGLSFCILSGSAG-------------RHSKHQLQELAVKNGGCIVENPLPNDPKC 713
            .|:..:|...:|     .:||||             :.::.:|...:.:.|    ..|:|
Mouse   904 PTTGGSSGENEG-----TAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGG----IKPIP----- 954

  Fly   714 FCIAGDETFLVKRLILQQPRTCDIVRMEWLLRVCQKQELELKPRDLIAA-TEPLQQDLAECFDRH 777
                                                :...:||.:.:|. :.|::..:    .|.
Mouse   955 ------------------------------------KHSPMKPGEKLAVKSSPVKVGM----KRK 979

  Fly   778 GDSYTKDIANVEELQDLLQGIEL-----TADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFF 837
            ....|..:..|  |.|:..|:.|     |.|                          |:.|..:|
Mouse   980 ATDETPCLKKV--LLDVFTGVRLYLPPSTPD--------------------------FKRLKRYF 1016

  Fly   838 YSPHGDEVAKLLFLQNGGRIVDDSDPQLNLGFICMSSDIDNDHFEHWLHNHSKLTTDKVLNSAWI 902
            .:..||.|                            .:.|.....|.|.|..|.|..::::|.||
Mouse  1017 VAFDGDLV----------------------------QEFDMGSATHVLGNREKNTDAQLVSSEWI 1053

  Fly   903 HQCHREGILL 912
            ..|.|:..|:
Mouse  1054 WACIRKRRLI 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	41/196 (21%)
		dnl1	84..613	CDD:273147	134/590 (23%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	62/235 (26%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	36/171 (21%)
		BRCT	668..745	CDD:214602	10/89 (11%)
Lig3	XP_006532410.1	zf-PARP	151..236	CDD:366219
		dnl1	374..886	CDD:273147	135/605 (22%)
		LIG3_BRCT	990..1061	CDD:374781	24/126 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820