Protein Alignment NFAT and nfatc3b

DIOPT Version :10

• Sequence 1: NP_001096974.1
• Gene: NFAT / 32321
• FlyBaseID: FBgn0030505
• Length: 1457
• Species: Drosophila melanogaster
• Sequence 2: XP_073799520.1
• Gene: nfatc3b / 566869
• ZFINID: ZDB-GENE-100922-25
• Length: 996
• Species: Danio rerio
• Alignment Length: 1038
• Identity: 241/1038 - (23%)
• Similarity: 383/1038 - (36%)
• Gaps: 291/1038 - (28%)

  Fly   142 PPPCDNSND-------------SGLGFDQHTELRSSAGAGGVTDPAANG-----GSGSNSGQRS- 187
            |.||.:.:.             |.:..|...||..:|....:..|..:.     .|..||.|.|
Zfish   133 PSPCSSLSSRSWLSDASSCESFSHIYDDVEAELNEAAAQVRLASPLVSPLPSPLPSPLNSPQASP 197

  Fly   188 --SLLVNSALTNTVAAAAAAAAAAVASNTLQQHQQHHQQQQQQ--QQQQQQQQQQQQQQQQQQQH 248
              |.||:       ...:....||...:...::||:|||..|.  .|.....|..:....::...
Zfish   198 QVSPLVS-------PFGSPGCMAAYGDDPWYRYQQYHQQSLQYPFAQSLSPYQSPRTSITEETWL 255

  Fly   249 SPQQHLIRAIPVSRSRNNTKVMAHCLEDLDLISASSEDSSTIATPAGLDEDTGFVNDTKTTTTGG 313
            ||:.|                           |:||..||...:|.|...
Zfish   256 SPRPH---------------------------SSSSRPSSRPTSPCGKRR--------------- 278

  Fly   314 NSSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQQQHQ----LFQYNGLLLQ---PQQQLQQQ 371
            :||::...|:     |:...:.||......:.||.::...    ...|:.|.:.   |.:..:..
Zfish   279 HSSAEVIPGL-----ASPHLSPNATPSHSPRGSVTEESWMGGATFAPYHTLPVDVDVPSKTRRTY 338

  Fly   372 QSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLE------- 429
            |::|.|.|              ..|...|     :|:..:|:.:.....:|:: |:|:
Zfish   339 QANHNQDQ--------------ASLFSGQ-----EDSGLQDQGLANSGIAVSL-PSLKKEDIVEH 383

  Fly   430 --ATPSP----PPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPT 488
              |.|:|    .|..||....:|   .||
Zfish   384 FLAVPTPFSWVKPKQASTLYRST---SLP------------------------------------ 409

  Fly   489 TPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGY-DKVAVLQVF 552
             ||:....|..||.:|::..||...|||.|:|||||||:|...|. .|:|:|.|| :|...||:|
Zfish   410 -PLDCPLPSQYGQCELKMEIQPRAHHRAHYETEGSRGAIKSECGR-HPVVKLIGYNEKPVSLQMF 472

  Fly   553 IGT-DIGRVAPHMFYQACKVAGKN-STQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNV 615
            ||| |...:.||.|||..::.||. :|...:..:..|.|:||...||.:|..:.||.||||.||.
Zfish   473 IGTADERYIRPHPFYQVHRITGKTVATPSQDTVISNTKVLEIPLLPENNMCASIDCAGILKLRNS 537

  Fly   616 DVEHRFPE-HLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQ--PPGVPEICKKSL 677
            |:|.|..| .:.:||    ||.|.|||..:.:.:|...:|||.|:||.|:|  ...:|::...|.
Zfish   538 DIELRKGETDIGRKN----TRVRAVFRVNIPQHNGKLLSLQVASSPIECSQRLAQELPQVESFSP 598

  Fly   678 NSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKE 742
            ......||.|:.|.|:|...::.|||.|     .|.|..|:              ||.:|.|..|
Zfish   599 ACGSASGGEEMRITGQNLNSESTVVFLE-----KGSDGKTQ--------------WEVNVRPLPE 644

  Fly   743 YLHQTHLICTVPPYLHQNILKPVQVQVSIVSSG--KKSEPHTFTYTA---KGQYTTLAAA----- 797
            ....|.::..:|||..:......|||. .|::|  |:|....||:.:   |.:::|..||
Zfish   645 KSQNTSIVVKIPPYYKKTTASSTQVQF-YVTNGKRKRSGSQFFTFLSAQVKQEFSTQPAAPSGQT 708

  Fly   798 ----------STLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNV--EAKHEID 850
                      .||..:.|.        :.|..:||..|....|..|.|:.:...::  .:..|.:
Zfish   709 ELLEQWLLSEETLCASTHL--------SFSPQDASYLSRSHPADRSFNSRTDLHSMFPSSLIEFN 765

  Fly   851 SGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTP 915
            |.:...|  .|.|....:.|||...|                 |...|:||..
Zfish   766 SSLYQKP--HQDPSYKAQPSLPVAFP-----------------EQTATQLDKG------------ 799

  Fly   916 DSPNAALQYHRFARKPSLDTIMYD-------------QSNSLPGFPTV-VAPATAAAVAAAVDID 966
                     ::..|..:||.::.|             ||:|..|.||| ..|:|:.:.:.  :.:
Zfish   800 ---------YQCIRSQNLDNLILDASGLHTMAAVSIPQSSSSQGLPTVSKVPSTSPSTSK--NAE 853

  Fly   967 PTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFI 1031
            |.:.::             |....|....:..::...:::.:::::...|....|.......|.|
Zfish   854 PASASL-------------VESSEQYCVSENGDRLNIKEEPEEEKELDFQSVGLQDITLDDGKTI 905

  Fly  1032 DELTKSTSVVSSNGTTEPALFTTSAVIDHALTDILQAKVGIAPPNVVL---ERSLSLSSTNSS 1091
            |.:|..|..:::...|......|..|...:: ||.:.|.......:..   |||.|::|...|
Zfish   906 DLITVKTLTLNTLDLTCTHRHHTCTVHQESV-DIRKFKTQFIYVEIQFLNKERSKSVNSAQCS 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NFAT	NP_001096974.1	RHD-n_TonEBP	502..665	CDD:143642	72/166 (43%)
		IPT	669..787	CDD:472823	33/119 (28%)
nfatc3b	XP_073799520.1	None