Protein Alignment NFAT and nfatc3a

DIOPT Version :9

• Sequence 1: NP_001096974.1
• Gene: NFAT / 32321
• FlyBaseID: FBgn0030505
• Length: 1457
• Species: Drosophila melanogaster
• Sequence 2: XP_021333591.1
• Gene: nfatc3a / 561772
• ZFINID: ZDB-GENE-041111-41
• Length: 1074
• Species: Danio rerio
• Alignment Length: 1141
• Identity: 259/1141 - (22%)
• Similarity: 393/1141 - (34%)
• Gaps: 352/1141 - (30%)

  Fly   228 QQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPVSRSRNNTKVMAHCLEDLDLISASSEDSSTIAT 292
            ||:.:..:.:.:.:......|..        |:||.        |....||   .|..|||...:
Zfish   125 QQEMEASEDEMRSKGPDGDYHDR--------PLSRD--------HLYLPLD---HSYRDSSLSPS 170

  Fly   293 PAGLDEDTGFVNDTKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQ------------QQH 345
            |........:.:|.        ||.:....|:...::.:..|...|.|..            .|.
Zfish   171 PCSSLSSRSWFSDA--------SSCESISHVYDDVDSELNEAAARFTLGSPLTSPGCSPQTGTQE 227

  Fly   346 SVQQQQHQLFQYNGLLLQPQQQLQQQQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDD--- 407
            .|.||||.                    ||.........|.||..:..::..|:.......|
Zfish   228 EVWQQQHH--------------------HHHPAFAHSLSHSHGHSLSPRQSPCHSPRTSVTDENW 272

  Fly   408 ---------------ACSEDEFIRKIAS---------SVTMSPTLEATPSPPP------------ 436
                           .|.:    |:.:|         |...|||  |||.|.|
Zfish   273 LSPRSPSRPSSRPTSPCGK----RRHSSADICYLGSLSPHHSPT--ATPGPSPRGSVTEDTWIGS 331

  Fly   437 ---------------------------IVASVAPATTIVSL------LPLISS--GNSNNNNNNN 466
                                       ..|.:.|....:|:      .||:.|  .:|.:....:
Zfish   332 PSMGVSPFQCCPSEADIPSKTRKTSQDCTAVIQPGKGDLSMDDSGNGSPLLDSPAEDSMHGLKKD 396

  Fly   467 NIETKFISARN-------------VTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARY 518
            ....:|:|..:             :.|.:|    ..||:....:..||.:|:|..||:..|||.|
Zfish   397 GSGEQFLSVPSHFTWNKPKPGHTPIFRASN----LPPLDWPLPNQYGQYELKIEVQPKAHHRAHY 457

  Fly   519 QTEGSRGAVKDRSGNGFPIVRLTGYDKVAV-LQVFIGT-DIGRVAPHMFYQACKVAGKN-STQCN 580
            :|||||||:|..|| |.||::|.||::..| ||:|||| |...:.||.|||..::.||. :|...
Zfish   458 ETEGSRGAIKATSG-GHPIIKLLGYNEKPVNLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQ 521

  Fly   581 EKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPE-HLAQKNKKKSTRCRMVFRTQL 644
            |..:..|.|:||...||.:|:.:.||.||||.||.|:|.|..| .:.:||    ||.|:|||..:
Zfish   522 EIIITSTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKN----TRVRVVFRVHI 582

  Fly   645 TRDDGTTETLQVCSNPIICTQPPG--VPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETY 707
            .:.:|...:||..|.|:.|:|...  :|::.|.|::||||.|..|:.|.|.||..::.|:|.|
Zfish   583 PQPNGKVVSLQSSSVPVECSQRSAQELPQVEKASISSCPVSGREEMLITGSNFFPESKVIFLE-- 645

  Fly   708 DSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIV 772
               .|.|...:              ||......:|....:.:...||||..:.:...||||..:.
Zfish   646 ---KGPDGRPQ--------------WEVEAKIIREKSQGSSIAVEVPPYHSKTVTSAVQVQFYVC 693

  Fly   773 S-SGKKSEPHTFTY---TAKGQY-------------------TTLAAASTLSNTIHAQDVSGFMD 814
            : ..|:|:...|||   ..|.::                   .:|..|..||:..|:....|.:.
Zfish   694 NGKRKRSQSQRFTYLPVLVKQEHRDDLDSPAVPPMSMPLVHAASLVCAQPLSSPEHSHPPDGLLS 758

  Fly   815 TTSASNASGSSGWSA-AGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQIPM--GVRRSSLPSVTP 876
            ::....|:|.....| ....|:.|..    ...|....|:..|| ..|:|.  |...::.||..|
Zfish   759 SSPRGLAAGLHPLQAPCAPMGSPTLP----HLPHLQARGLNAPP-ECQMPFHPGPAATARPSYPP 818

  Fly   877 M-----ITDQQLVHLNAVAASA-EALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDT 935
            :     ...||.:.:.|.:..| |.:..:.|.:..|:...|
Zfish   819 IQHNMPFNGQQSLPMTAGSPQAYERMPFQADPAGCHTLGVG------------------------ 859

  Fly   936 IMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHE- 999
            ::|..::|.|  |:.|.|...::        |:.||    ....|:::.|       ....:|.
Zfish   860 MVYGPASSTP--PSGVPPGPGSS--------PSHVA----CTGSNQVMAH-------SAPHLHSL 903

  Fly  1000 -QQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALT 1063
             .......|.........|.|.|.|:..|:....:.:.|....||
Zfish   904 GYHHPTPGQIPSPTHTLGQPPPQLQRPLVYHPAGQRSASCPTPSS-------------------- 948

  Fly  1064 DILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAALGG 1128
                     ||.::|       .|.:|..|.....|.|..||.:.....||.     .|..||.|
Zfish   949 ---------APAHMV-------PSPHSGPSSPQLHSLPYHSPTSPSPTSNSP-----LGPMALSG 992

  Fly  1129 -PAP---VDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDIAMQP- 1188
             |:|   ..|..||          |||..|.                |.:......|| |..:|
Zfish   993 QPSPQASSPVLAGL----------SPSGPLA----------------HPLAQQGERLN-IKQEPE 1030

  Fly  1189 --EPTQQDAAVAALALSNI-------MMSPPTAASG 1215
              |||.:...:..:.|.::       |...|.|..|
Zfish  1031 DREPTFRTIGLQDITLDDVNEIIGRDMSQAPGAHGG 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NFAT	NP_001096974.1	RHD-n_TonEBP	502..665	CDD:143642	74/166 (45%)
		IPT	669..787	CDD:301692	34/121 (28%)
nfatc3a	XP_021333591.1	RHD-n_NFAT	431..604	CDD:143641	76/177 (43%)
		IPT_NFAT	609..709	CDD:238583	34/118 (29%)
		Atrophin-1	714..>1033	CDD:331285	80/436 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7672
SonicParanoid	1	1.000	-	-		X749
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.900