DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NFAT and Nfat5

DIOPT Version :9

Sequence 1:NP_001096974.1 Gene:NFAT / 32321 FlyBaseID:FBgn0030505 Length:1457 Species:Drosophila melanogaster
Sequence 2:NP_061293.2 Gene:Nfat5 / 54446 MGIID:1859333 Length:1552 Species:Mus musculus


Alignment Length:1408 Identity:366/1408 - (25%)
Similarity:556/1408 - (39%) Gaps:408/1408 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 PPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSL--------------LVN 192
            |||.:.|..|        ..::|.|..|...||......|::...||:              :.:
Mouse    56 PPPRETSVAS--------MSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYS 112

  Fly   193 SALTNTVAAAAAAAAAAV------------ASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQ 245
            :::|::.|....:.::||            ..||:|||..                         
Mouse   113 TSVTDSKAMQVESCSSAVGVSNRGVSEKQLTGNTVQQHPS------------------------- 152

  Fly   246 QQHSPQQHLIRAI--PVSRSRNNTKVMAHCLEDLDLISASSEDSSTIATPAGLDEDTG---FVND 305
               :|::|.:..|  |.....:|:::             |.:|..     .||:.:..   ::.|
Mouse   153 ---TPKRHTVLYISPPPEDLLDNSRM-------------SCQDEG-----CGLESEQSCSMWMED 196

  Fly   306 TKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQQQHQLFQYNGLLLQPQQQLQQ 370
            :.:..:..::||                                       ||.....|      
Mouse   197 SPSNFSNMSTSS---------------------------------------YNDNTEVP------ 216

  Fly   371 QQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLEATPSPP 435
                 ::.:::....|.|  :||:  :|.:..:|..||.|                         
Mouse   217 -----RKSRKRNPKQRPG--VKRR--DCEESNMDIFDADS------------------------- 247

  Fly   436 PIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPTT----PLNSVAS 496
                :.|| ..::|.|...:.|||...|..       :.::..|.|  |:.|..    |:.|   
Mouse   248 ----AKAP-HYVLSQLTTDNKGNSKAGNGT-------LDSQKGTGV--KKSPMLCGQYPVKS--- 295

  Fly   497 SNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGTDIGRVA 561
              :|: :|:|:.|||.||||||.||||||:||||:..|||.|:|.|:::..|||||:|.|.|||.
Mouse   296 --EGK-ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVK 357

  Fly   562 PHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPEHLA 626
            ||.|||||:|.|:|:|.|.|..::||.|||:...|..:||:..|||||||.||.|||.|..   .
Mouse   358 PHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIG---I 419

  Fly   627 QKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGGLELFII 691
            ..:||||||.|:|||..:||.||:|.|||..|:||:||||.|||||.||||:||.|.|..|:|:|
Mouse   420 AGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLI 484

  Fly   692 GKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPY 756
            ||||||.|.|:|||.....|.                    |:.....|.|..||.|||..||||
Mouse   485 GKNFLKGTKVIFQENVSDENS--------------------WKSEAEIDMELFHQNHLIVKVPPY 529

  Fly   757 LHQNILKPVQVQVSIV-SSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASN 820
            ..|:|..||.|.:.:| ::|:..:...||||..      .||..|:..: .:::|     :.|..
Mouse   530 HDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPD------PAAGALNVNV-KKEIS-----SPARP 582

  Fly   821 ASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQI-------PMGV----RRSSLPSV 874
            .|......|.      .:||.||:....:.:.::.|.|::.:       ||.|    |.|.:...
Mouse   583 CSFEEAMKAM------KTTGCNVDKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQT 641

  Fly   875 TPMI--TDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIM 937
            |..|  |.|.|..::.:|..|   ......|:||      .||:|.|.. |....|..|...|.:
Mouse   642 TKSIGSTQQTLETISNIAGGA---PFSSPSSSSH------LTPESENQQ-QLQPKAYNPETLTTI 696

  Fly   938 YDQSNSLPG-FPTVVAPATAAAVAAAVDIDPTAVAV---AVELAVKNEIVKHVVQQHQQMQ-EQM 997
            ..|..|.|| ||         ||:||..: |::.|:   |.:...:....:..:|....:. .|:
Mouse   697 QTQDISQPGTFP---------AVSAASQL-PSSDALLQQATQFQTREAQSRDTIQSDTVVNLSQL 751

  Fly   998 HEQQQQQQQQQQQQQQQQQQQ------PQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSA 1056
            .|..||||...|:|.|..|||      |......|:...|.:|...:...|:.|....::     
Mouse   752 TEASQQQQSPLQEQAQTLQQQIPSNIFPSPSSVSQLQSTIQQLQAGSFTGSAAGGRSGSV----- 811

  Fly  1057 VIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALA 1121
                   |::|.         |||....|||. ..|:..|:|:.  ...|..||...|:      
Mouse   812 -------DLVQQ---------VLEAQQQLSSV-LFSTPDGNENV--QEQLNADIFQVSQ------ 851

  Fly  1122 GAAALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNIL-----APHQVTMANSIL 1181
                                 |.| :|||. :..||..|......|:|     :.||.| .|::.
Mouse   852 ---------------------IQN-SVSPG-MFSSAESAVHTRPDNLLPGRADSVHQQT-ENTLS 892

  Fly  1182 NDIAMQPEPTQQDAAVAALAL---SNIMMSP--------PTAASGVGVGDTLPPTPATMQPEVAA 1235
            |....|.:..|...:.||:.:   .:|..:.        |:|||..|   :|..:|...||....
Mouse   893 NQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSAASASG---SLQQSPVYQQPSHMM 954

  Fly  1236 TATSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLV----DL 1296
            :|..|   |..::...:..:                  ||.||   |||...|.:.|.|    ..
Mouse   955 SALPT---NEDMQMQCELFS------------------SPPAA---SGNETSTTTTPQVATPGST 995

  Fly  1297 LLNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRV-----TGHVSG--HV 1354
            :....::.:.....|.|..::.:.||:|.....|         |....:|     |.::..  :.
Mouse   996 MFQTPSSGDGEETGAQAKQIQNSVFQTMVQMQRS---------GDSQPQVNLFSSTKNIMSVQNN 1051

  Fly  1355 TSHHRGHHLPVVPPTPQESLIVALASENALQKSVATAA--VTTNGAVMTQQASAPNTAGSIL--- 1414
            .:..:|:.|     ..|.|.:::|.|.|.||:|..:.|  ......:...|..:..|.|||.   
Mouse  1052 GTQQQGNSL-----FQQGSEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSIFHSP 1111

  Fly  1415 -PAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQ 1456
             |......:.|::..:||      :....|:.|:.:..|:..|
Mouse  1112 NPIVHSQTSTASSEQLQP------SMFHSQNTIAVLQGSSVPQ 1148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NFATNP_001096974.1 RHD-n_TonEBP 502..665 CDD:143642 93/162 (57%)
IPT 669..787 CDD:301692 49/118 (42%)
Nfat5NP_061293.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..107 13/58 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..238 11/98 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..283 6/32 (19%)
RHD-n_TonEBP 298..458 CDD:143642 93/163 (57%)
IPT_NFAT 462..561 CDD:238583 49/118 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 625..684 20/68 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..903 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1011 10/60 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1528
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837063
Domainoid 1 1.000 186 1.000 Domainoid score I3351
eggNOG 1 0.900 - - E1_28KEG
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006955
OrthoInspector 1 1.000 - - oto94081
orthoMCL 1 0.900 - - OOG6_107943
Panther 1 1.100 - - O PTHR12533
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
87.790

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