DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NFAT and Nfatc3

DIOPT Version :9

Sequence 1:	NP_001096974.1	Gene:	NFAT / 32321	FlyBaseID:	FBgn0030505	Length:	1457	Species:	Drosophila melanogaster
Sequence 2:	XP_038953769.1	Gene:	Nfatc3 / 361400	RGDID:	1308692	Length:	1141	Species:	Rattus norvegicus

Alignment Length:	1069	Identity:	262/1069 - (24%)
Similarity:	390/1069 - (36%)	Gaps:	323/1069 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 QQQQQQQQQQQQQQQQQQQQQHSPQQHLI---------RAIPVSRSRNNTKVMAHCLEDLDLISA 282
            ::...||.........:|...|||:..:.         .:.|.||..:......|...::....:
  Rat   223 EESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGS 287

  Fly   283 SSEDSSTIATP-----AGLDEDTGFVNDTKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQ 342
            .|...|.:.:|     ..:.|||..   |....||...|..||.
  Rat   288 LSPHHSPVPSPGHSPRGSVTEDTWL---TAPVHTGSGLSPAPFP--------------------- 328

  Fly   343 QQHSVQQQQHQLFQYNGLLLQPQQQLQQQQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDD 407
                        |||   .::....|:.:::...|..           |...|||
  Rat   329 ------------FQY---CVETDIPLKTRKTSDDQAA-----------ILPGKLE---------- 357

  Fly   408 ACSEDEFIRKIASSVTMSPTLEATPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKF 472
            .||:|:        .::||:.|.  |....:.|..|       |...|||:            :|
  Rat   358 VCSDDQ--------GSLSPSRET--SVDDGLGSQYP-------LKKDSSGD------------QF 393

  Fly   473 ISARNVTRVANKRQPTTPLNSVAS---------SNDGQVQLEILSQPEQQHRARYQTEGSRGAVK 528
            :|..:....:..:...||:...:|         ::.||.:|:|..||:..|||.|:|||||||||
  Rat   394 LSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVK 458

  Fly   529 DRSGNGFPIVRLTGY-DKVAVLQVFIGT-DIGRVAPHMFYQACKVAGKN-STQCNEKKVDGTMVI 590
            ..:| |.|:|:|.|| :|...||:|||| |...:.||.|||..::.||. :|...|..:..|.|:
  Rat   459 ASTG-GHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVL 522

  Fly   591 EIDFKPETDMTITCDCVGILKERNVDVEHRFPE-HLAQKNKKKSTRCRMVFRTQLTRDDGTTETL 654
            ||...||.:|:.:.||.||||.||.|:|.|..| .:.:||    ||.|:|||..:.:..|...:|
  Rat   523 EIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKN----TRVRLVFRVHIPQPSGKVLSL 583

  Fly   655 QVCSNPIICTQPPG--VPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDD--P 715
            |:.|.|:.|:|...  :|.|.|.|:|||.|:||.|:.:.|.|||.::.::|.|     .|.|  |
  Rat   584 QIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLE-----KGQDGRP 643

  Fly   716 ATEI---AVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVS-SGK 776
            ..|.   .:|::..||                   |::..||||.:..:...|||...:.: ..|
  Rat   644 HWEAEGKIIREKCQGG-------------------HIVLEVPPYHNPAVTSAVQVHFYLCNGKRK 689

  Fly   777 KSEPHTFTYT---------AKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGG 832
            ||:...||||         .:.:.|.|::..:|.....||       |...|:.:|
  Rat   690 KSQSQRFTYTPGTRVLMKQEQREDTDLSSVPSLPVPHSAQ-------TQRPSSDTG--------- 738

  Fly   833 SGNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSL----PSVTPMITDQQLVHLNAVAASA 893
                          |..||.:..|           ||.:    |:...|||...|..|......|
  Rat   739 --------------HPHDSALSAP-----------RSLICPVQPAYASMITSTHLPQLQCRDEGA 778

  Fly   894 EALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPTVVAPATAAA 958
            ...:..:..|..|.|.  :.||.||..: .|.      |:.|.||:....||..|
  Rat   779 GKEQHIIPSSVMHQPF--QVTPTSPMGS-SYQ------SIQTNMYNGPTCLPMNP---------- 824

  Fly   959 VAAAVDIDPTAVAVAVELAVKNEI--------------------------VKHVVQQHQQMQEQ- 996
             |::.:.||  |....:.|:.|.:                          ..|.||....:|..
  Rat   825 -ASSQEFDP--VLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMG 886

  Fly   997 MHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHA 1061
            .|.....|:........|...||....|        .:|...|...|.....||       ..||
  Rat   887 YHCSSAGQRSLSSPVAAQVTGQPSSHLQ--------PITYCPSHPGSATAASPA-------ASHA 936

  Fly  1062 LTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAAL 1126
            |:   .:.:. .||      |..|.|....|..||:.|||  ||:|:   ::|...:..|.:...
  Rat   937 LS---SSPIS-GPP------SPQLQSMPYQSPSSGTASSP--SPVTR---MHSGQHSTQAQSTGQ 986

  Fly  1127 GGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDIAMQPEPT 1191
            ||   :.|...|....:.:||..|      ..|||                      ::::|||.
  Rat   987 GG---LSVPSSLVCHSLCDPASFP------PGGAA----------------------VSIKPEPE 1020

  Fly  1192 QQDAAVAALALSNI------MMSPPTAAS 1214
            .|:...|.:.|.:|      |:|..|..|
  Rat  1021 DQEPNFATIGLQDITLDDVVMLSSLTQTS 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NFAT	NP_001096974.1	RHD-n_TonEBP	502..665	CDD:143642	74/166 (45%)
NFAT	NP_001096974.1	IPT	669..787	CDD:301692	39/132 (30%)
Nfatc3	XP_038953769.1	RHD-n_NFAT	422..595	CDD:143641	76/177 (43%)
Nfatc3	XP_038953769.1	IPT_NFAT	600..700	CDD:238583	38/123 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X749
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010