DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NFAT and Nfatc2

DIOPT Version :9

Sequence 1:	NP_001096974.1	Gene:	NFAT / 32321	FlyBaseID:	FBgn0030505	Length:	1457	Species:	Drosophila melanogaster
Sequence 2:	NP_001101275.1	Gene:	Nfatc2 / 311658	RGDID:	1307690	Length:	931	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	173/632 - (27%)
Similarity:	247/632 - (39%)	Gaps:	178/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 CSEDEFIRKIASSVTMSPTLEATPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFI 473
            |.::|.......|:.:.|     |:.|   ..:.||..|.| :|:.:|
  Rat   357 CEQEERRNSAPESILLVP-----PTWP---KQLVPAIPICS-IPVTAS----------------- 395

  Fly   474 SARNVTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIV 538
                          ..||....|:..|..:|.|..||:..|||.|:|||||||||..:| |.|:|
  Rat   396 --------------LPPLEWPLSNQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVV 445

  Fly   539 RLTGY--DKVAVLQVFIGTDIGRV-APHMFYQACKVAGKN-STQCNEKKVDGTMVIEIDFKPETD 599
            :|.||  :|...||:||||...|: .||.|||..::.||. :|...||.|..|.|:||..:|:.:
  Rat   446 QLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNN 510

  Fly   600 MTITCDCVGILKERNVDVEHRFPE-HLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIIC 663
            |..|.||.||||.||.|:|.|..| .:.:||    ||.|:|||..:....|...:||..||||.|
  Rat   511 MRATIDCAGILKLRNADIELRKGETDIGRKN----TRVRLVFRVHIPEPSGRIVSLQAASNPIEC 571

  Fly   664 TQPPG--VPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQE-TYDSVNGDDPATEIAVRQQL 725
            :|...  :|.:.::.::||.|.||.::.:.|:||..::.|||.| |.|.             ||
  Rat   572 SQRSAHELPMVERQDMDSCLVYGGQQMILTGQNFTAESKVVFMEKTTDG-------------QQ- 622

  Fly   726 IGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVS-SGKKSEPHTFTY---- 785
                  :||.....||:......|...:|.|.:::|..||:|...::: ..|:|:|..|||
  Rat   623 ------IWEMEATVDKDKSQPNMLFVEIPEYRNKHIRVPVKVNFYVINGKRKRSQPQHFTYHPVP 681

  Fly   786 TAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEID 850
            ..|.:.:.....|.:.:..|                         ||.|:.
  Rat   682 AIKTEPSDEYEPSLICSPAH-------------------------GGLGSQ-------------- 707

  Fly   851 SGMMPPPITTQIPMGVRRSSLPS--VTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGES 913
                  |...|.||   .:..||  |..|...||.                         .:|.|
  Rat   708 ------PYYPQHPM---LAESPSCLVATMAPCQQF-------------------------RSGLS 738

  Fly   914 TPD------SPNAALQYHRFARKPSLDTIMYDQSNSL-PGFPTVVAPATAAAVAAAVDIDPTAVA 971
            :||      ||.|||               |.:|.|| ||......|:..||.....|...:.:.
  Rat   739 SPDARYQQQSPAAAL---------------YQRSKSLSPGLLGYQQPSLLAAPLGLADAHRSVLV 788

  Fly   972 VAVELAV---KNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQQQQQQ 1015
            .|.....   :...:.|.....||....:|.....||.:....|:.|
  Rat   789 HAGSQGQGQGQGSTLPHTSSASQQASPVIHYSPTNQQLRGGGHQEFQ 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NFAT	NP_001096974.1	RHD-n_TonEBP	502..665	CDD:143642	78/167 (47%)
NFAT	NP_001096974.1	IPT	669..787	CDD:301692	34/123 (28%)
Nfatc2	NP_001101275.1	RHD-n_NFAT	400..574	CDD:143641	80/178 (45%)
Nfatc2	NP_001101275.1	IPT_NFAT	579..679	CDD:238583	34/119 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X749
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870