DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NFAT and nfatc3

DIOPT Version :9

Sequence 1:	NP_001096974.1	Gene:	NFAT / 32321	FlyBaseID:	FBgn0030505	Length:	1457	Species:	Drosophila melanogaster
Sequence 2:	NP_001135546.1	Gene:	nfatc3 / 100216091	XenbaseID:	XB-GENE-493918	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	799	Identity:	209/799 - (26%)
Similarity:	318/799 - (39%)	Gaps:	201/799 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 SPQQHLI-------------RAIPVSRSRNNTKVMAHCLEDLDLIS--ASSEDSSTIATPAGLDE 298
            ||::|.:             |..|....||:       :.|.:.:|  .||:..|...:|.|...
Frog   208 SPREHPVEKTWHVCSVSPSSRQSPCHSPRNS-------ITDENWLSPRPSSKPPSRPTSPCGKRR 265

  Fly   299 D-------TGFVNDTKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQ-QQHQLF 355
            .       :|.|:...:..|....|  |.|.:   ||.:.        |....|.|.. ..:|.:
Frog   266 HSSADIFYSGLVSPHYSPATSPGPS--PRGSI---TEDSW--------LNASPHPVPSLSLYQCW 317

  Fly   356 QYNGLLLQPQQQLQQQQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDD-ACSEDEFIRKIA 419
            |...:.|:.::..:.                |...:..|      .||:.:| ||        ::
Frog   318 QETAIPLKTRKTSED----------------HSARLAGK------TELNTEDLAC--------LS 352

  Fly   420 SSVTMSPTLEATPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANK 484
            .:|.| ||.|:..|..|::..  .:|.....:|...:.|.:.:.:.....|..:
Frog   353 PTVDM-PTDESACSQHPVIQD--SSTDQFLSVPSHFTWNKHKSGHTPVFRTSSL----------- 403

  Fly   485 RQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGY-DKVAV 548
                .||:....|..||.:|::..||:..|||.|:|||||||||..:|| .|||:|||| :|...
Frog   404 ----PPLDWALPSRYGQYELKVDVQPKTHHRAHYETEGSRGAVKAVTGN-HPIVKLTGYTEKPLN 463

  Fly   549 LQVFIGT-DIGRVAPHMFYQACKVAGKN-STQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILK 611
            ||:|||| |...|.||.|||..::.||. :|...|..:..|.|:||...||.:||.:.||.||||
Frog   464 LQMFIGTADDRYVRPHAFYQVHRITGKTVATASQEIVITNTKVLEIPLLPENNMTASIDCAGILK 528

  Fly   612 ERNVDVEHRFPE-HLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPG--VPEIC 673
            .||.|:|.|..| .:.:||    ||.|:|||..:.:..|...:||..|.||.|:|...  :|::.
Frog   529 LRNSDIELRKGETDIGRKN----TRVRLVFRVHIPQTSGKVLSLQAASVPIECSQRSAQELPQVE 589

  Fly   674 KKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVL 738
            |.|:|||.|:|||||.|.|.||:.|:.|:|.|     .|.|..|.              ||....
Frog   590 KYSINSCSVNGGLELVITGSNFMPDSKVIFLE-----KGQDGCTH--------------WEAEGK 635

  Fly   739 PDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVS-SGKKSEPHTFTYT--------------AK 788
            ...:.....:::..:|.|.::.|...||||..:.: ..|:|:...|.||              .:
Frog   636 TVFKKCQMNNIVVEIPAYHNKTIAADVQVQFYVCNGKRKRSQSQRFNYTPVLLKQENLEDGDLQE 700

  Fly   789 GQYTTLAAASTLSN--TIHA----QDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNVEA-- 845
            ....:||....:|:  .||.    ||......|..:|:..|                   ||.
Frog   701 ATAVSLAKGRGISDLRMIHTSLLFQDQRSICKTLKSSSPPG-------------------VECPT 746

  Fly   846 --------KHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAEALKTELDD 902
                    ||||       |..::|     :....|.:|...|.:.:....|:..:...|..: .
Frog   747 QPTFTSSLKHEI-------PQISKI-----QEPCTSSSPSTADPETMENYPVSIYSSPQKQSM-P 798

  Fly   903 SNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYD-QSNSLPGFPTVVAPATAAAVAAAVDID 966
            ....||    ..|..|:::|.......:||..|  :| :...:...||:..|...:|.:...|
Frog   799 YQCFSP----DIPVLPSSSLTAMPHTGQPSSHT--HDCRLRGISLSPTITHPRQNSASSHPTD-- 855

  Fly   967 PTAVAVAVELAVKNEIVKH 985
                   :.|.:|.|:|.|
Frog   856 -------MSLGIKAELVDH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NFAT	NP_001096974.1	RHD-n_TonEBP	502..665	CDD:143642	78/166 (47%)
NFAT	NP_001096974.1	IPT	669..787	CDD:301692	37/132 (28%)
nfatc3	NP_001135546.1	RHD-n_NFAT	407..580	CDD:143641	81/177 (46%)
nfatc3	NP_001135546.1	IPT_NFAT	585..685	CDD:238583	36/118 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7672
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030