Protein Alignment CG2691 and RRP12

DIOPT Version :10

• Sequence 1: NP_572906.2
• Gene: CG2691 / 32320
• FlyBaseID: FBgn0030504
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: NP_015313.1
• Gene: RRP12 / 856095
• SGDID: S000005933
• Length: 1228
• Species: Saccharomyces cerevisiae
• Alignment Length: 1300
• Identity: 274/1300 - (21%)
• Similarity: 517/1300 - (39%)
• Gaps: 255/1300 - (19%)

  Fly   131 KLVTSFRSSSALHKEMLAILSALTEIIRENGGGESSTEY----------FLLLMEQ-IEAATEE- 183
            |:.:...|.....|.:..||:|    :.||..|:::.:.          |:.|::| ::.:|.|
Yeast    18 KIRSQVNSKLENQKHIAIILTA----VEENIAGQATNDVSKNIVNYIISFMSLLDQAVDPSTHEI 78

  Fly   184 RDI---VAGVTLLAMGINSVPAPVLKKRFAQTADTMQRLLQRFMESTNQSVIRHVIGCLSVILRA 245
            :||   .:...||.:..:..|..:|:.:|::....:...:.  .|..|..:||..||||..:|.|
Yeast    79 KDIQLASSSTYLLDLIFHYSPKVLLRSKFSEILTKIAPCIT--AEKANAPLIRAAIGCLESLLIA 141

  Fly   246 QDYAAWSYSSTFQY-------FDAILAFSIHSQPKIRKAAQHAIALIIHGSCFMLPAIKSDDNEM 303
            ||..||  ::|:..       ...||..|:..:||:||.|..|:..::     :.|.:
Yeast   142 QDAQAW--NNTYDLNVTPKRGLQGILELSLDVRPKVRKRALDAVHAVL-----LNPPV------- 192

  Fly   304 DEAVEQPKVKHHPASSRVAKFC---LAQFKPEV--LANAQ-----------TTVLHTLELLKDTL 352
                  .....|.|:..||.||   ||....::  |:|.|           .:|:.:|.|:...:
Yeast   193 ------APTAEHVAAVFVADFCDKQLAGILNDLSNLSNKQLKAQKTKEDINASVMRSLRLITSVV 251

  Fly   353 Y--GFKTEDIRSVCEHLLSIMTAAN---VLVRTNCFQTLYSLFLKK--SPNLNASLCAKLLAAIH 410
            .  .:.:..|..:|:.||.:..::.   |.....||::::....:.  |..|..:...::|..|.
Yeast   252 STGQWPSSQIEPLCDVLLGVTKSSEQYLVSASFECFESMFKTMAETTISSGLAENKYLRVLDTIF 316

  Fly   411 EYRPDKSDIRQTIAWVTVLKEGHLHLATMQLDLCMQALPRLIDVCTTDLWLSDQKELVAGVSNCI 475
            ..:|...|...|.:|:.|:.:|....||.|....::.:|.:..:..|.| .|:..|:....|.|:
Yeast   317 ALKPSNVDTLLTKSWIAVVIKGMSTYATHQPLKALRKIPGVFHIMCTYL-ASETPEVYQAASQCL 380

  Fly   476 KELLQDCVSRACATAEDAQCNR--QSVSRIIASLHK----MLNAPFGEISRFVILIFSFVFEACG 534
            ..:|.:.|.........:...:  ::|..||:.:.|    .|:..:...||.::.|....|..
Yeast   381 ISILSESVKDDLLLYTPSVDEKVFKNVDEIISQIAKTFIDFLSIRYSHCSREILKILVAAFNK-- 443

  Fly   535 KLFGSELTPPLMTICKRYDTQSAH-------RLQIEHTVISAIKALGPELVLTAIPL-ADGKGVM 591
              |.....|..:...|..||...:       |.:||..:.::|.|:|||::|...|| .|.....
Yeast   444 --FRYRSNPHFLKSLKIVDTWRVNEEQFMDLRNEIELVIGASISAMGPEMILAEAPLNLDNPSSE 506

  Fly   592 QLERSWLLPLLREGANGASLQFFKEKIVALAMDCQLKWKEFAEAKNNSSSHIYELLCCQLWGLFP 656
            :..|:|||||:|:....|:|..|:.::.......|.|:.:..|  .:....:::.:..|:|...|
Yeast   507 RPGRAWLLPLIRDYTKNANLATFQNELAPYIKSFQSKFDKVPE--ESIQLRVFQTIVDQIWSTLP 569

  Fly   657 GFCRQPRD--PEYLRYLAPTLGAAVEKNPEFRPPIYDGLMELLGDNQS----------------- 702
            .||..|.|  ..:....|..|.:.:....|.|..|...|..|...|.|
Yeast   570 RFCELPMDLRESFTDEFASELSSLLYSEVELRTTICHALKVLAESNVSYAEESSSHNVLLLQRFP 634

  Fly   703 -AECHQAIGQY----AKNFLPRLFNIYTQ-KPNGTYEADQRKRVLEVIRLYISRAPADVQLELFE 761
             :|..:.| :|    :.|.|..|||:||| .||.      |..:||.|..|:.....:...:.|.
Yeast   635 ISEAQKNI-EYLSTKSTNLLAVLFNVYTQTTPNA------RSYILETIDQYLKITSKEDLEKTFN 692

  Fly   762 NA---------------------QEQLAASALASFEYDAFFDINAAIVRVQTCKGIKAYFDKYMA 805
            |.                     :.||.|:.|         |:...::.........|.|..:..
Yeast   693 NVCGLLKNSMNEESSGNVNKEKKKPQLTATLL---------DLIICMITYLPVSSYSALFSMFSL 748

  Fly   806 PILRNDKSKLVAKDEQKLKKQQRKTYELLRELMTSELPSCQKFTRKNSIVLQQILLDSFNTSCNV 870
            .:  |....|:          |::.|.::.:|  |||.|......:....::.:::||.::....
Yeast   749 TV--NSADALI----------QKRAYRIITKL--SELKSGSTAVAQFISDIENVMVDSASSVQTS 799

  Fly   871 CQASRLHCLKSLIDCHSNLAYNDQL--VMKAIPEAVLNYKEFSNYKEQVA-EQLI---------K 923
            .:|:||..:|::::    |...|.|  :::.:.|.:|:.|:.:....:.| :.||         .
Yeast   800 AKAARLTAIKTIVE----LLPLDHLDFIVRTVAEVILSTKDVNEKSRETAFDTLICMGRKMNEPN 860

  Fly   924 SITQLYHDAG----------KINDFVDILTAGFAGD-EMLVTNTILAFRAVLQQQGEHLTVATLE 977
            .|.:|:...|          .|::|..|::||..|: :.:|:::|..:..::.:....|....|.
Yeast   861 GIIKLFQIPGYDPTTPDQSSSISEFFKIISAGLIGESQHMVSSSITGYACLVFEFKNELDSGILM 925

  Fly   978 FVLQQVSVFLVQKSRKQAEAAIAFLITFIKVMPIPLVANHLEAIMRSLSAMTKDTKRYCRIQIGY 1042
            .:...:.::|...||:..::||.|....:..:|..|:...:..::..|...:.:...:.:.::.:
Yeast   926 DIYDTIELYLTSNSREIVKSAIGFTKVCVLGLPEELMRPKVPELLLKLLRWSHEHTGHFKAKVKH 990

  Fly  1043 LLKKLCIRFSPGELAGFVPGDDDVIHRRLKMIRKRTRRDLRKKQNLEAQEDSSDDELVSGLQEKS 1107
            ::::|..||....:....|.:|   .|.|..|||...|:.||           |:|:.:|:.:.:
Yeast   991 IIERLIRRFGYDYIEANFPEED---RRLLTNIRKMRNRNKRK-----------DEEVTTGVSDVA 1041

  Fly  1108 YT--------IDDMLADSDSDLPEDMDAKDEAGAAAAASKRSKNAKQQKSTYIREDPDEIVDLAD 1164
            .|        .|:.:..||.:.....|.::.    .|..|....|||    :|.|..|..:||.|
Yeast  1042 ATKGSRFMSAFDEAVYGSDEENDNGSDQEEN----VAGGKMKNGAKQ----FIVESGDNPLDLLD 1098

  Fly  1165 LKSIGNVLTSGSAQTATPAQSQKTKAQLPNGGFKTADDGRLIISDKALRGQGGNDQSDDDSDSDA 1229
            .:::.::    |:.........:.:|:..:..|....:|:|::     :||.....:.||..|..
Yeast  1099 SQTLAHI----SSTRPKKFNKNQNRARFNDDAFNFDSEGKLVV-----KGQPKPSTNVDDPLSAV 1154

  Fly  1230 SM---AYGTVAKQPKV----------KRGMEDD---SSDEDKLQQKLVPKRVRKGDDAMSMKSGK 1278
            :.   ||....|...|          |.|.:.|   ..|:.:...:|:..||.:|:     |.||
Yeast  1155 TSGINAYLEAVKSGPVRGQRNKLKFRKNGKDSDEFGDDDDGEKDSRLMRGRVNQGN-----KIGK 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2691	NP_572906.2	NUC173	503..700	CDD:462386	52/210 (25%)
RRP12	NP_015313.1	NUC173	414..615	CDD:462386	50/206 (24%)