DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2691 and Y46E12BL.2

DIOPT Version :9

Sequence 1:	NP_001285218.1	Gene:	CG2691 / 32320	FlyBaseID:	FBgn0030504	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_497319.1	Gene:	Y46E12BL.2 / 266878	WormBaseID:	WBGene00021595	Length:	1334	Species:	Caenorhabditis elegans

Alignment Length:	1478	Identity:	348/1478 - (23%)
Similarity:	613/1478 - (41%)	Gaps:	252/1478 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKFRSKLKRNGKGKTWSRGESATSNPTQMKHRMKAKSRFFQPNLSLAAATTTGLTMEAVHKHEQS 66
            |.||.:..:.|..| ::.|.:..||||:.|||..|.        :...|:..|..|.||    :.
Worm     4 GNFRHRTSKKGAAK-FNSGSACESNPTRSKHRAAAN--------AARNASFGGAGMLAV----ED 55

  Fly    67 QAFNAETTTVNDVAGSLRSFKLDDDDDGMSGSGTAPTGTAPTGTIKTFQTFASNYSGCSNTCFQK 131
            :..|  |...:|:.  |.:..:...|.|.|.......|    |..|     .|.::.|:|..|..
Worm    56 RLMN--TAAADDML--LSALPIHSMDIGSSSKSMVSEG----GLSK-----LSGFTACTNPAFDS 107

  Fly   132 LVTSFRSSSALHKEMLAILSALTEIIRENGGGESSTEYFLLLMEQIEAAT--EERDIVAGVTLLA 194
            :...::|.|::..|::::|:|:.|:|:|..|.||..||...||..:|.::  ..|...|...||.
Worm   108 VNRVWKSGSSIQAEVVSVLAAIAEVIKERDGKESDVEYCAALMTALEGSSLGNPRRTAAIAYLLH 172

  Fly   195 MGINSVPAPVLKKRFAQTADTMQRLLQRFMESTNQSVIRHVIGCLSVILRAQDYAAWSYSSTFQY 259
            :.:..||..||:.:|.:....:...|...::||..|.::::|..|.:|||||..:.||.::|...
Worm   173 LIVRKVPKEVLQAQFHRFVQILYTKLLENVDSTEGSALKNLISVLGIILRAQQASVWSSANTRNM 237

  Fly   260 FDAILAFSIHSQPKIRKAAQHAIALIIHGSCFMLPAIKSDDNEMDEAVEQPKVKHHPASSRVAKF 324
            ..::.|.:.|.:|.:|..|:..|..:      :...:.:.||.:           ||||..|.:.
Worm   238 LVSVAALAAHDKPWVRTMARRVIRAV------LTDPVTATDNGL-----------HPASGAVGQL 285

  Fly   325 CLAQFKPEVLANA--QTTVLHTLELLKDTLYGFKTEDIRSVCEHLLSIMTAANVLVRTNCFQTLY 387
            .|...:..:..::  .|.|:..|.||:..::.......:.:.|.:|.....::.:|:.:..|.|:
Worm   286 ILNHIESFLGRSSADNTNVVRFLCLLEGVMHKMPAVLFKKMAEAMLKCFAISDSMVKCSALQCLH 350

  Fly   388 SLFLKKSP---NLNASLCAKLLAAIHEYRPDKSDIRQTIAWVTVLKEGHLHL----ATMQLDLCM 445
            .. |::.|   .|.....|.||.|:.:.....:|:..|..|:..|.|.|:.|    :...:....
Worm   351 RA-LQRQPCDSALPTETNALLLTALRQLGASVTDVTVTAYWMQALAEAHVCLTAKDSKKSVQQAF 414

  Fly   446 QALPRLIDVCTTDLWLSDQKELVAGVSNCIKELLQDCVSRACATAEDAQCNRQSVSRIIASLHKM 510
            |.||..:.:     :.:..::|.......:..::::.:.      :||.|.:    .:::.||..
Worm   415 QTLPLFVKI-----FEAGNEQLAQVTYQSLTRVIENSIQ------DDAACGK----FLLSQLHVA 464

  Fly   511 LNAPFGEISRFVILIFSFVFEACGK-LFGSELTPPLMTICK-RYDTQSAHRLQIEHTVISAIKAL 573
            :......:.:|::.....::|.||: |.|:|||..:..:.: |.......:.:::.|:.:|::.:
Worm   465 MTMKSASVWKFILRAQMKLYETCGEGLQGAELTKVMEDLARLRQSDDCFCKTELDFTIGAAVRHI 529

  Fly   574 GPELVLTAIPL-ADGKGVM---QLERSWLLPLLREGANGASLQFFKEKIVALAMDCQLKWKEFAE 634
            |...|:..:.| .|....:   ...||||||:||...:.|.:..|....:.:||...   :....
Worm   530 GVAHVMNILSLEVDPDAAILSTDFTRSWLLPVLRVNIHNAPISLFISHFLPIAMKIH---RRLPT 591

  Fly   635 AKNNSSSHIYELLCCQLWGLFPGFCRQPRD-----PEYLRYLAPTLGAAVEKNPEFRPPIYDGLM 694
            .:......:|.....|||.|.|.||..|.|     |:    :||.||||:.:..:.|..:.:.:.
Worm   592 LQAPQVQRLYSTFQFQLWELLPSFCESPSDLETAFPD----IAPILGAALNERKDLRMTVLNAIR 652

  Fly   695 E----LLGDNQSAECHQAIGQYAKNFLPRLFNIYT-QKPNGTYEADQ--RKRVLEVIRLYISRAP 752
            .    .|..:..||..:.:.:|||||:|..||:|| ...:|.|: |:  |..|||.||||....|
Worm   653 RALRFCLEPDAPAERVEVMSRYAKNFMPIFFNMYTGSVVDGGYD-DKGVRLSVLEAIRLYTEVTP 716

  Fly   753 ADVQLELFENAQEQLAAS-----ALASFEYDAFFDINAAIVRVQTCKGIKAYFDKYMAPILRNDK 812
            ||:.....::|   :|.|     ::||.:.....||..|:.:|...:.:....|..|.....:|.
Worm   717 ADLVTRYVDSA---IAKSKDHDESVASQKQARVLDILCALAKVAENENVSKILDTIMPWFNSSDT 778

  Fly   813 SKLVAKDEQKLKKQQRKTYELLRELMTSEL-PSCQKFTRKNSIVLQQILLDSFNTSCNVCQASRL 876
            :.:           |:|.:.:|.|::.... |..:......:..::..|.....:.....:||..
Worm   779 NGV-----------QKKAFRILEEVIQRRSHPEIEHLLDTRNDYVENALFKPIESISFPARASYC 832

  Fly   877 HCLKSLID-CHSNLAYNDQLVMKAIPEAVLNYKEFSN-YKEQVAEQLIKSITQLYHDAGKINDFV 939
            .|:..|.| |::.....| |..|.|...:|...:.:| :..|.:.:.|:.|      ..||.|.|
Worm   833 SCVHMLYDGCNTMKEVTD-LTEKLIRNIILLLDKDNNVHTRQNSSKCIQFI------CSKILDLV 890

  Fly   940 D---ILTAGFAGDEML-----------------------VTNTILAFRAVLQQQGEHL-TVAT-- 975
            |   |.|...|.:.:|                       ..:.::|...:.|:|.:.| |:||
Worm   891 DDPTIDTPSAALEPVLSKLYELTTISAEQKTTGDIPLHVARSCLVAANIIAQKQVKILNTIATSK 955

  Fly   976 -LEFVLQQVSVFLVQKSRKQAEAAIAFL-ITFIKVM----PIPLVANHLEAIMRSL--SAMTKDT 1032
             :.|....:.         :..||:..| |..::|:    |..::....|.|:.::  ..:|.|.
Worm   956 MISFACSWIG---------EGRAAVRILAIRLMRVLCQKIPEVMLQQFREQILTTVFEGQLTSDL 1011

  Fly  1033 KRYCRIQIGYLLKKLCIRFSPGELAGFVPGDDDVIHRRLKMIRKRTRRDLRKKQNLEAQEDSSDD 1097
            ....|.....||:.|..:|....|..:....|.:  :::|.|.|..:|.:||....|.:.|..|.
Worm  1012 TIKVRKANRLLLEVLVEKFGVNVLQKYTEKPDWL--KQMKNIEKIRKRKVRKAGEAEMEHDDEDG 1074

  Fly  1098 -ELVSGLQEKSYTIDDMLADSDSDLPEDMDAKDEAGAAAAASKRSKNAKQQKSTYIR--EDPDEI 1159
             ..:||......|..   ||:..:|.||.||.:|:.:.....|:|:..    |.:::  .|.|..
Worm  1075 ASAISGSNVSGRTAG---ADTILELLEDSDADNESDSEEQLMKKSRVG----SVWLKNESDGDVP 1132

  Fly  1160 VDLADLKSIGNVLTSGSAQTATPA--QSQKTKA----QLPNGGFKTADDGRLII-------SDKA 1211
            :||.|...:.:.:|     |..||  :.:|.||    |....||:.:.||::|:       .||.
Worm  1133 MDLLDSSRMMDQIT-----TMNPAILEKRKKKALERRQKVEAGFQFSKDGKMIVLGDDEEDEDKK 1192

  Fly  1212 LRGQ-----GGNDQSDDDSDSDASMAYGTVAKQPKVKRGMEDDSSDEDKLQQKLVPKRVRKGDDA 1271
            ..|:     |.:...|||.|.:.....|        |:.::::|..||::        :...||.
Worm  1193 QIGKRKMRSGYDGLGDDDEDDEDGPTKG--------KKRVKENSDSEDEI--------LSDDDDD 1241

  Fly  1272 MSMKSGKTTAS-SRYTAGGKGIHRQLTAGNSDAMSVKSGKSTSRPAGSEYGSKKAKGDMKKSGK- 1334
            ...|..||..| :..:.|||||:|.           .||||   ..||..|:|:.:.......|
Worm  1242 DDEKDAKTFVSRAAPSYGGKGIYRD-----------TSGKS---QVGSSVGAKRQQKQKPNKPKQ 1292

  Fly  1335 ----LDPYAYIPLTRNNLNKRKRSMNSRKFKSVLRGAGAENGGAGGGR 1378
                :.||||:||......:..|.:...|.||          |.|||:
Worm  1293 QQKSVQPYAYVPLRNKTAKQDVRQILKAKRKS----------GKGGGK 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2691	NP_001285218.1	NUC173	504..696	CDD:285386	48/206 (23%)
Y46E12BL.2	NP_497319.1	NUC173	457..653	CDD:369724	48/202 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157648
Domainoid	1	1.000	124	1.000	Domainoid score	I3419
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22370
Inparanoid	1	1.050	268	1.000	Inparanoid score	I1855
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55423
OrthoDB	1	1.010	-	-		D48729at33208
OrthoFinder	1	1.000	-	-		FOG0003758
OrthoInspector	1	1.000	-	-		oto19488
orthoMCL	1	0.900	-	-		OOG6_103654
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1214
SonicParanoid	1	1.000	-	-		X3121
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.800