DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2691 and RRP12

DIOPT Version :9

Sequence 1:	NP_001285218.1	Gene:	CG2691 / 32320	FlyBaseID:	FBgn0030504	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	XP_024303687.1	Gene:	RRP12 / 23223	HGNCID:	29100	Length:	1357	Species:	Homo sapiens

Alignment Length:	1468	Identity:	424/1468 - (28%)
Similarity:	690/1468 - (47%)	Gaps:	222/1468 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKFRS----KLKRNGKGKTWSRGESATSNPTQMKHRMKAKSRFFQPNLSLAAATTTGLTMEAVHK 62
            ||..|    ||||      |.:|.|:.|||...:||..|:||||.     ..:..:.||::||..
Human     5 GKLPSGVSAKLKR------WKKGHSSDSNPAICRHRQAARSRFFS-----RPSGRSDLTVDAVKL 58

  Fly    63 HEQSQAFNAETTTVNDVAGSLRSFKLDDDDDGMSGSGTAPTGTAPTGTIKTFQTFASNYSGCSNT 127
            |.:.|            :||||..|.:..:..|........      |.|:..||.|..|.|:|.
Human    59 HNELQ------------SGSLRLGKSEAPETPMEEEAELVL------TEKSSGTFLSGLSDCTNV 105

  Fly   128 CFQKLVTSFRSSSALHKEMLAILSALTEIIRENGGGESSTEYFLLLMEQIEAATEERDIVAGVTL 192
            .|.|:...:.|:||.|||:.|:|:|:||:||..||.|:.||||..||..:||......:.|...|
Human   106 TFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYL 170

  Fly   193 LAMGINSVPAPVLKKRFAQTADTMQRLLQRFMESTNQSVIRHVIGCLSVILRAQDYAAWSYSSTF 257
            |.:.:..||:|||.|:|:.|:.....::.....|.:.||:|.|:.||:.:||.||..||.|..|.
Human   171 LNLVLKRVPSPVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTL 235

  Fly   258 QYFDAILAFSIHSQPKIRKAAQHAIALIIHGSCFML---PAIKSDDNEMDEAVEQPKVKHHPASS 319
            |.:..:|:|::|.:|||||||||.:..::.||.||.   ||                  ||||:.
Human   236 QVYHGLLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPA------------------HHPAAI 282

  Fly   320 RVAKFCLAQFKPEVLANAQTTVLHTLELLKDTLYGFKTEDIRSVCEHLLSIMTAANVLVRTNCFQ 384
            ..||||:.:.:....:...||.||.|.||||.|..|....::|..|.||.:||.::|||.....|
Human   283 STAKFCIQEIEKSGGSKEATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQ 347

  Fly   385 TLYSLFLKKS--PNLNASLCAKLLAAIHEYRPDKSDIRQTIAWVTVLKEGHLHLATMQLDLCMQA 447
            ..:|||..:.  ..|:|.|.|:::.|:::|.|.::|::..:||:.|:::.|::|..:|.||.:..
Human   348 AFHSLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQWDLGLGH 412

  Fly   448 LPRLIDVCTTDLWLSDQKELVAGVSNCIKELLQDCVSRACA----TAEDAQCNRQSVSRIIASLH 508
            |||......|.| ||...:::...:..:||:|::||:...|    ....|....|||:::..::.
Human   413 LPRFFGTAVTCL-LSPHSQVLTAATQSLKEILKECVAPHMADIGSVTSSASGPAQSVAKMFRAVE 476

  Fly   509 KMLNAPFGEISRFVILIFSFVFEACGKLFGSELTPPLMTICK-RYDTQSAHRLQIEHTVISAIKA 572
            :.|...|......|:.:....|||||:.....:...|.::|. |......|...::..|.:|:.:
Human   477 EGLTYKFHAAWSSVLQLLCVFFEACGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTS 541

  Fly   573 LGPELVLTAIPL-ADG-KGVMQLERSWLLPLLREGANGASLQFFKEKIVALAMDCQLKWKEFAEA 635
            :|||:||.|:|| .|| :..:...||||||::|:......|.||....:.||...:.|..:.|:|
Human   542 MGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKAMDLAQA 606

  Fly   636 KNNSSSHIYELLCCQLWGLFPGFCRQPRDPEY-LRYLAPTLGAAVEKNPEFRPPIYDGLMELLGD 699
            .:...|.||:.|..|:|.|.||||.:|.|... .:.||.|||.|:.:.|:.|..:...|..|:..
Human   607 GSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVTVCQALRTLITK 671

  Fly   700 NQSAECHQA-IGQYAKNFLPRLFNIYTQKPNGTYEADQRKRVLEVIRLYISRAPADVQLELFENA 763
            ...||..:| :.::||||||.|||:|.|..........|:.|||.||.|::.....:...|.|.|
Human   672 GCQAEADRAEVSRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKA 736

  Fly   764 QEQLAASALASFEYDAFFDINAAIVRVQTCKGIKAYFDKY--MAPILRNDKSKLVAKDEQKLKKQ 826
            .|::...|.:.|...:..|:   :|.:..|....|....|  :.|.|           |.|....
Human   737 SEKVLDPASSDFTRLSVLDL---VVALAPCADEAAISKLYSTIRPYL-----------ESKAHGV 787

  Fly   827 QRKTYELLRELMTSELPSCQKFTRKNSIVLQQILLDSFNTSCNVCQASRLHCLKSLIDCHSNLAY 891
            |:|.|.:|.|:..|.......|.:.:...|::.||||..::.:..:..||.||..::...|  |.
Human   788 QKKAYRVLEEVCASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLS--AE 850

  Fly   892 NDQLVMKAIPEAVLNYKEFSNYKEQVAEQLIKSITQLY-----------------HDAGKIND-- 937
            :.:.:...|||.:|..||.|....:.|..|:..:...:                 |.|.::..
Human   851 HKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEGEAQGAGGGHSAHRLGGGK 915

  Fly   938 ----------------------------------------------FVDILTAGFAGDEMLVTNT 956
                                                          ::.::..|..|...:|:.:
Human   916 HPSKKVGRALCPGPGQAAPLWPSAPLPGGSFLLDPRWSLSPEALQCYLVLIYPGLVGAVTMVSCS 980

  Fly   957 ILAFRAVLQQQGEHLTVATLEFVLQQVSVFLVQKSRKQAEAAIAFLITFIKVMPIPLVANHLEAI 1021
            |||...:|.:....:..:|:|.:|:.|.:.|..::|...::|:.|:...:.||.:..:|.|::.:
Human   981 ILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQLV 1045

  Fly  1022 MRSLSAMTKDTKRYCRIQIGYLLKKLCIRFSPGELAGFVPGDDDVIHRRLKMIRKRTRRDLRKKQ 1086
            |.::..::.|.:|:.|:::..|..|...:|....:...:|   :..||.|..|||...|..|.:.
Human  1046 MEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKRLLP---EEYHRVLVNIRKAEARAKRHRA 1107

  Fly  1087 NLEA--QEDSSDDELVSGLQEKSYTIDDMLADSDSDLPEDMDAKDEAGAAAAASKRSKNAKQQKS 1149
            ..:|  :|:..::|.....|.|..:|:::||||:.:  ||.:.::.    :...::.|.|:|:..
Human  1108 LSQAAVEEEEEEEEEEEPAQGKGDSIEEILADSEDE--EDNEEEER----SRGKEQRKLARQRSR 1166

  Fly  1150 TYIRE-DPDEIVDLADLKSIGNVLTSGSAQTATPAQSQKTKAQLPNGGFKTADDGRLIISDKALR 1213
            .:::| ..||.::..|.|....||    |....|.:.:|     .:.|||.:.||||||.::|
Human  1167 AWLKEGGGDEPLNFLDPKVAQRVL----ATQPGPGRGRK-----KDHGFKVSADGRLIIREEA-- 1220

  Fly  1214 GQGGNDQSDDDSDSDASMAYGTVAKQPKVKRGMEDDSSD--ED-----KLQQKLVPKRVRKGDDA 1271
              .||...:::.                 .:|.:::.:|  ||     |..|||  |..::.::.
Human  1221 --DGNKMEEEEG-----------------AKGEDEEMADPMEDVIIRNKKHQKL--KHQKEAEEE 1264

  Fly  1272 MSMKSGKTTASSRYTAGGKGIHRQLTAGNSDAMSVKSGKSTSRPAGSEYGSKKAKGDMKKSGKLD 1336
                  :.....:|.|||.||||.:.   ..||           .|:||.:||||||:||.|:.|
Human  1265 ------ELEIPPQYQAGGSGIHRPVA---KKAM-----------PGAEYKAKKAKGDVKKKGRPD 1309

  Fly  1337 PYAYIPLTRNNLNKRKRSMNSRKFKSVLRGA--GAENG 1372
            |||||||.|:.||:||:.....:||.:::.|  |::.|
Human  1310 PYAYIPLNRSKLNRRKKMKLQGQFKGLVKAARRGSQVG 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2691	NP_001285218.1	NUC173	504..696	CDD:285386	61/195 (31%)
RRP12	XP_024303687.1	NUC173	471..671	CDD:311885	62/199 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143560
Domainoid	1	1.000	276	1.000	Domainoid score	I1751
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22370
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1103
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55423
OrthoDB	1	1.010	-	-		D48729at33208
OrthoFinder	1	1.000	-	-		FOG0003758
OrthoInspector	1	1.000	-	-		oto90463
orthoMCL	1	0.900	-	-		OOG6_103654
Panther	1	1.100	-	-	LDO	PTHR21576
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1214
SonicParanoid	1	1.000	-	-		X3121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900