Protein Alignment CG2691 and Rrp12

DIOPT Version :10

• Sequence 1: NP_572906.2
• Gene: CG2691 / 32320
• FlyBaseID: FBgn0030504
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: NP_955518.1
• Gene: Rrp12 / 107094
• MGIID: 2147437
• Length: 1295
• Species: Mus musculus
• Alignment Length: 1419
• Identity: 427/1419 - (30%)
• Similarity: 695/1419 - (48%)
• Gaps: 171/1419 - (12%)

  Fly     2 GKFRS----KLKRNGKGKTWSRGESATSNPTQMKHRMKAKSRFFQPNLSLAAATTTGLTMEAVHK 62
            ||..|    ||||      |.:|.|:.|||...:||..|:||||.     ..:..:.||::||..
Mouse     5 GKLPSGVSAKLKR------WKKGHSSDSNPATCRHRQAARSRFFS-----RPSGKSDLTVDAVKL 58

  Fly    63 HEQSQAFNAETTTVNDVAGSLRSFKLDDDDDGMSGSGTAPTGTAPTG-----TIKTFQTFASNYS 122
            |.:.|            :|:|           ..|...||..|....     |.|:..||.|..|
Mouse    59 HNELQ------------SGTL-----------SLGKSQAPETTMDQDPEVAFTEKSSGTFLSGLS 100

  Fly   123 GCSNTCFQKLVTSFRSSSALHKEMLAILSALTEIIRENGGGESSTEYFLLLMEQIEAATEERDIV 187
            .|:|..|.|:...:.|:||.|||:.|:|:|:||:||..||.|:.||||..||..:||......:.
Mouse   101 DCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLA 165

  Fly   188 AGVTLLAMGINSVPAPVLKKRFAQTADTMQRLLQRFMESTNQSVIRHVIGCLSVILRAQDYAAWS 252
            |...||.:.:..||:|||.|:|:.|:.....::.....|.:.|.:|.|:.||:::||.||..||.
Mouse   166 AVAYLLNLVLKRVPSPVLMKKFSDTSKAFMDIMSAQASSGSTSALRWVLSCLAILLRKQDLEAWG 230

  Fly   253 YSSTFQYFDAILAFSIHSQPKIRKAAQHAIALIIHGSCFML----PAIKSDDNEMDEAVEQPKVK 313
            |..|.|.:..:|:|::|::|||||||||.:..::.||.||.    ||
Mouse   231 YPITLQVYHGLLSFTVHAKPKIRKAAQHGVCSVLKGSDFMFGEKAPA------------------ 277

  Fly   314 HHPASSRVAKFCLAQFKPEVLANAQTTVLHTLELLKDTLYGFKTEDIRSVCEHLLSIMTAANVLV 378
            ||||:...||||:.:.:....:...||.||.|.||||.|..|....::|..|.||.:||..:|||
Mouse   278 HHPAAVSTAKFCIQEIEKSGGSKEATTTLHMLTLLKDMLPCFPEGLVKSCSETLLRVMTLNHVLV 342

  Fly   379 RTNCFQTLYSLF-LKKSPN-LNASLCAKLLAAIHEYRPDKSDIRQTIAWVTVLKEGHLHLATMQL 441
            .....|..::|| .|.||: |:|.|.|:::.|:::|.|.::|::..:||:.|:::.|::|..:|.
Mouse   343 TACAMQAFHNLFHAKPSPSTLSAELNAQIVTALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQR 407

  Fly   442 DLCMQALPRLIDVCTTDLWLSDQKELVAGVSNCIKELLQDCVSRACA----TAEDAQCNRQSVSR 502
            ||.:..|.|......|.| ||...::.|..:..:||:|::||:...|    ....|....|.:::
Mouse   408 DLGLGHLARFFGTAVTCL-LSPHSQVAAAATQTLKEILKECVAPHIADIGSVTSSASGPPQYITK 471

  Fly   503 IIASLHKMLNAPFGEISRFVILIFSFVFEACGKLFGSELTPPLMTICK-RYDTQSAHRLQIEHTV 566
            :..::.:.|...|......|:.:....||||||.....:...|.::|. |......|...::..|
Mouse   472 MFRAVEEGLTYKFHAAWSSVLQLLGVFFEACGKQAHPVMKKCLQSLCDLRLSPHFPHTAALDQAV 536

  Fly   567 ISAIKALGPELVLTAIPL-ADG-KGVMQLERSWLLPLLREGANGASLQFFKEKIVALAMDCQLKW 629
            .:|:.::|||:||.|:|| .|| :..:...||||||::|:......|.||....:.||...:.|.
Mouse   537 GAAVTSMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTTYFLPLATTLKRKA 601

  Fly   630 KEFAEAKNNSSSHIYELLCCQLWGLFPGFCRQPRD-PEYLRYLAPTLGAAVEKNPEFRPPIYDGL 693
            .:.|:|.:...|.||:.|..|:|.|.||||.:|.| ....:.||.|||.|:.:.|:.|..:...|
Mouse   602 MDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVAASFKGLARTLGTAINERPDLRVTVCQAL 666

  Fly   694 MELLGDNQSAECHQA-IGQYAKNFLPRLFNIYTQKPNGTYEADQRKRVLEVIRLYISRAPADVQL 757
            ..|:.....||..:| :.::||||||.|||:|.|.......|..|:.|||.|:.|::...|.:..
Mouse   667 RTLITKGCEAEADRAEVSRFAKNFLPILFNLYGQPVAAGEAAAPRRAVLETIKTYLTITEAQLVN 731

  Fly   758 ELFENAQEQLAASALASFEYDAFFDINAAIVRVQTCKGIKAYFDKYMAPILRNDKSKLVAKDEQK 822
            ...|.|.|::...|.:.|...:..|:..|:........|...:.. :.|.|           |.|
Mouse   732 SFLEKATEKVLDPASSDFTRLSVLDLVVALAPYSDEAAISKLYST-IRPYL-----------ESK 784

  Fly   823 LKKQQRKTYELLRELMTSELPSCQKFTRKNSIVLQQILLDSFNTSCNVCQASRLHCLKSLIDCHS 887
            :...|:|.|.:|.|:..|......:|.:.:...|::.||||..|:.:..:..||.||..::...|
Mouse   785 VHGVQKKAYRVLEEVCASSQGPAARFVQSHLDDLKKTLLDSLRTTSSPAKRPRLKCLIHIVKTLS 849

  Fly   888 NLAYNDQLVMKAIPEAVLNYKEFSNYKEQVAEQLIKSITQLYHDAGK-----INDFVDILTAGFA 947
              |.:::.:...|||.:|..||.|....:.|..|:..:...:...|.     :..::.::..|..
Mouse   850 --AEHEEFIAALIPEVILCTKEVSVGARKSAFTLLVEMGHAFLRFGSNQEDALQRYLVLIYPGLL 912

  Fly   948 GDEMLVTNTILAFRAVLQQQGEHLTVATLEFVLQQVSVFLVQKSRKQAEAAIAFLITFIKVMPIP 1012
            |....|:.:|||...:|.:....:..:|:|.:|:.|.:.|..::|...::|:.|:...:.||.:.
Mouse   913 GAVTTVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVV 977

  Fly  1013 LVANHLEAIMRSLSAMTKDTKRYCRIQIGYLLKKLCIRFSPGELAGFVPGDDDVIHRRLKMIRKR 1077
            .:|.|::.:|.::..::.|.:|:.|:::..|..|...:|....:.|.:|.:   .|:.|..|||.
Mouse   978 HLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFIKFTRKFGFELVKGLLPAE---YHKVLINIRKA 1039

  Fly  1078 TRRDLRKKQNLEA--QEDSSDDELVSGLQEKSYTIDDMLADSDSDLPEDMDAKDEAGAAAAASKR 1140
            ..|..:.:...:|  :|:..::|....:|.|..:|:::||||     ||.|.::|.|   ...::
Mouse  1040 ETRAKKHRALSQAAVEEEEEEEEEEEPVQSKGDSIEEILADS-----EDEDEEEERG---RGKEQ 1096

  Fly  1141 SKNAKQQKSTYIRE-DPDEIVDLADLKSIGNVLTSGSAQTATPAQSQKTKAQLPNGGFKTADDGR 1204
            .|.|:|:...:::| ..||.::..|.|....||    |....|.:.:|.     :.|||.:.|||
Mouse  1097 RKLARQRSRAWLKEGGGDEPLNFLDPKVAHRVL----ATQPGPGRGKKR-----DHGFKLSADGR 1152

  Fly  1205 LIISDKALRGQGGN--DQSD----DDSDSDASMAYGTVAKQPKVKRGMEDDSSDEDKLQQKLVPK 1263
            |||.::    :.||  ::.|    :|.|...:|...:|..:.|:||..||   :||:|:   :|
Mouse  1153 LIIREE----EDGNKVEEEDGTKGEDEDMTDAMEDASVRSKKKLKRQRED---EEDELE---IP- 1206

  Fly  1264 RVRKGDDAMSMKSGKTTASSRYTAGGKGIHRQLTAGNSDAMSVKSGKSTSRPAGSEYGSKKAKGD 1328
                               .||.|||.||||.:              :.....|:||.:||||||
Mouse  1207 -------------------PRYQAGGSGIHRPV--------------AKKAAPGAEYKAKKAKGD 1238

  Fly  1329 MKKSGKLDPYAYIPLTRNNLNKRKRSMNSRKFKSVLRGAGAENGGAGGGRVSKK 1382
            :||.|:||||||:||.|:.||:||:.....:||.:::  ..:.|...|.::.:|
Mouse  1239 VKKKGRLDPYAYVPLNRSKLNRRKKVKLQGQFKGLVK--ATQRGSQAGHKLRRK 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2691	NP_572906.2	NUC173	503..700	CDD:462386	63/200 (32%)
Rrp12	NP_955518.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		20/52 (38%)
		NUC173	472..672	CDD:462386	63/199 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1047..1241		71/254 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1273..1295		3/20 (15%)