DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HOXD3 and Scr

DIOPT Version :9

Sequence 1:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens
Sequence 2:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	131/435 - (30%)
Similarity:	174/435 - (40%)	Gaps:	103/435 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     5 QGQQAL---ELPECTMQK-----AAYYEN----PGLFGGYGYSKTTDTYGYSTPH----QPYPPP 53
            |.||.|   :.|:...|:     :..|.|    ||..||.|.|.:.:....:..:    |....|
  Fly   143 QQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASP 207

Human    54 AAASSLDTDYPGSACS-IQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPG-LNSEQQP 116
            ...|:.|.....|..| ::|.|........|..|..:....|..|:..|.|.|..|| :|
  Fly   208 QDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVN----- 267

Human   117 PQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSS--SATISK---QIFPWMKESRQNSKQKNS 176
                     :|..|   ||||....:...|..|.||  |....|   ||:||||.....:...|:
  Fly   268 ---------VPMHS---PGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNA 320

Human   177 CATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIW 241
               .||           :||.||:||..|.:||||||||||||.|.||:|:|:.|.|||||||||
  Fly   321 ---NGE-----------TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIW 371

Human   242 FQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAK-S 305
            |||||||:||:.|...:...|....|         .||          |...:|. .|..||. |
  Fly   372 FQNRRMKWKKEHKMASMNIVPYHMGP---------YGH----------PYHQFDI-HPSQFAHLS 416

Human   306 QPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPAS 370
            . :.:..:... .|:....:..:.||       .||...|:.|.:  |.|  :||..|.....|.
  Fly   417 AXDAWHFSGTGXRLNQLYQEPYQTAA-------AASAASGYQSQD--GGP--IGGGSVGVGGGAG 470

Human   371 GPVFNLGHL-------SHPSSASVDYSCAAQIPGNHHHGPCDPHP 408
            ||    |.|       |.|:|.....:.::|.|      .|..:|
  Fly   471 GP----GSLANGGSNGSGPNSLFASAASSSQAP------DCIKYP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		35/135 (26%)
		Antp-type hexapeptide	160..165		3/4 (75%)
		Homeobox	198..250	CDD:306543	39/51 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		4/26 (15%)
		DUF4074	369..430	CDD:315871	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432		2/9 (22%)
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	39/52 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810