DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango2 and YGR127W

DIOPT Version :9

Sequence 1:	NP_001245654.1	Gene:	Tango2 / 32319	FlyBaseID:	FBgn0030503	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_011643.1	Gene:	YGR127W / 853028	SGDID:	S000003359	Length:	312	Species:	Saccharomyces cerevisiae

Alignment Length:	383	Identity:	82/383 - (21%)
Similarity:	121/383 - (31%)	Gaps:	153/383 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCVIFFCADSNPQPGGYKLILASNRDEFFARATLSAAKWANADHVYGGIDL-EPGREG---GTWL 61
            ||:: ....::|.   |:|||.||||||.||.| .|..|.|.|.:....|| :...|.   |||.
Yeast     1 MCIL-MATRAHPD---YELILISNRDEFLARKT-HATCWHNNDFILSPYDLAKTSAEKQIFGTWS 60

  Fly    62 AIGHSAGFFKVGALLNLTGEPKPRDAVAHKNILQPHNHNSNSTGINLCPKTTTSNSYRHPNPNPI 126
            .|....   |:..:|||.              |....:|:.|....|.|....|
Yeast    61 GINKEG---KLATILNLK--------------LDNEQNNTKSRSRGLLPFIFLS----------- 97

  Fly   127 QNPNTNPSRGQSNNEHFLLGRGMIVADYVTRADEEHSILNYNERLLKDCTKYSA----------- 180
                                        :.:||.|            |...|..
Yeast    98 ----------------------------IHKADFE------------DWDNYKKFEGHYDGLKST 122

  Fly   181 --FNFVSIE--------IGSASQPARVKLLSNVPPTLEDF---QNGECYGFGNSLPHSPFEKVRH 232
              |||...:        |.|..:...| |.|.....|:.:   .||:.|. .:|:|...:|||:.
Yeast   123 GDFNFFYGDVIKKQYKVIDSLGRTFDV-LSSTCRKDLDSYMVVSNGKFYD-SSSIPGQAWEKVKV 185

  Fly   233 GKQEFEAIVKAHGEASVETLSAQLMQL--------------------------------LRNKHK 265
            .:...|.:|..:.|:..|.:.:...||                                ||..
Yeast   186 ARDSLENLVLENIESDEEKIISSCFQLASKSSLPSTISNPDVLQMVDPNVTMNTIYVPPLRRP-- 248

  Fly   266 FWPDDELKTRAPNWGEGLSSLNVHIEEHAYGSRTHSVVLVDSEN-KMHFIEETMTGLD 322
              |.|:|....|: |:            .||:|:..|:||..:: ::.|||..:...|
Yeast   249 --PRDDLGASIPD-GD------------YYGTRSQIVLLVSKDSTRVTFIERVLYSSD 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango2	NP_001245654.1	TANGO2	1..318	CDD:283414	81/377 (21%)
YGR127W	NP_011643.1	NRDE	1..309	CDD:225869	82/383 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341578
Domainoid	1	1.000	41	1.000	Domainoid score	I3243
eggNOG	1	0.900	-	-		E1_COG3332
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	41	1.000	Inparanoid score	I1884
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005228
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103320
Panther	1	1.100	-	-	LDO	PTHR17985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2350
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780