Protein Alignment tth and KAT6A

DIOPT Version :10

• Sequence 1: NP_572904.1
• Gene: tth / 32318
• FlyBaseID: FBgn0030502
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_006757.2
• Gene: KAT6A / 7994
• HGNCID: 13013
• Length: 2004
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 69/343 - (20%)
• Similarity: 117/343 - (34%)
• Gaps: 96/343 - (27%)

  Fly    14 NLAKIESFLKDVSYRE--TIEYSANFNTRLCSER--------------RHRLPFLDPQTGVAQNH 62
            |:.|....:||....|  :.|...:.:|.:.||:              :..|..|..:..:.  |
Human  1355 NMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIP--H 1417

  Fly    63 SQLFLDKRQRMPGFRQGQIYTYPAARWRKSRRQYLS-----KMYSRFPERPFQAL-----RKEHE 117
            |:|.|:..|.:....|.:...:..|  .:...:.|:     :.|::..|.|..::     ..||.
Human  1418 SELDLETVQAVQSLTQEESSEHEGA--YQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHN 1480

  Fly   118 ALVASGVNLGLSSLTSGVGSMPGSNSLASSSSLTLNMLTGG--GAAPAVLGSLHSDTAHDFNGAF 180
            :.::|            |.|.| |.|:.|.||..:..|..|  ..:|. .|||.:.:..
Human  1481 SPISS------------VQSHP-SQSVRSVSSPNVPALESGYTQISPE-QGSLSAPSMQ------ 1525

  Fly   181 SLEESSSLGAAGGDTSDSKDSQQQQHQQHQHQQQAVKEELLPKEWFYDDMDMNDVDSLEEPKSPA 245
            ::|.|..:     |.....|          |.||.|            |...:|:.|:|......
Human  1526 NMETSPMM-----DVPSVSD----------HSQQVV------------DSGFSDLGSIESTTENY 1563

  Fly   246 DDEYDYDPRYGNKKRRKRRPGKRGGDSGGGGGGGGAGGGGNSGGSSSSRRRSAAARSRITTTDAA 310
            ::...||...|            |...|..........||.|  ||||..:|:..   :|...|:
Human  1564 ENPSSYDSTMG------------GSICGNSSSQSSCSYGGLS--SSSSLTQSSCV---VTQQMAS 1611

  Fly   311 LDASLEAIESGESVPGSN 328
            :.:|...::.....|.:|
Human  1612 MGSSCSMMQQSSVQPAAN 1629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_572904.1	DPF1-3_N	24..89	CDD:464074	15/80 (19%)
KAT6A	NP_006757.2	Required for activation of RUNX1-1	1..144
		Required for nuclear localization	52..166
		H15	85..162	CDD:197772
		Interaction with PML. /evidence=ECO:0000269|PubMed:23431171	144..664
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		Interaction with RUNX1-1	312..664
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..464
		Catalytic	488..778
		PLN00104	<504..778	CDD:215056
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000269|PubMed:18794358	507..810
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	785..1445		18/93 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1461..1621		47/223 (21%)
		Interaction with PML. /evidence=ECO:0000269|PubMed:23431171	1517..1741		33/163 (20%)
		Interaction with RUNX1-2	1517..1642		33/163 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1637..1721
		Required for activation of RUNX1-2	1913..1948