DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tth and Dpf3

DIOPT Version :9

Sequence 1:	NP_001285216.1	Gene:	tth / 32318	FlyBaseID:	FBgn0030502	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001254554.1	Gene:	Dpf3 / 70127	MGIID:	1917377	Length:	378	Species:	Mus musculus

Alignment Length:	280	Identity:	81/280 - (28%)
Similarity:	110/280 - (39%)	Gaps:	103/280 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LKDVSYRETIEYSANFNTRLCSERRHRLPFLDPQTGVAQNHSQLFLDKRQRMPGFRQGQIYTYPA 86
            |.|..|:|.||:..::|:|||:||..||||||.|||||||:..::::||.|.||...||:|||||
Mouse    12 LGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPA 76

  Fly    87 ARWRKSRRQYLSKMYSRFPERPFQALRKEHEALVASGVNLGLSSLTSGVGSMPGSNSLASSSSLT 151
            ..|||.||.:.       ||.|                .|.|..:...| .:|......:|.|.|
Mouse    77 RCWRKKRRLHP-------PEDP----------------KLRLLEIKPEV-ELPLKKDGFTSESTT 117

  Fly   152 LN-MLTGGGAAPAVLGSLHSDTAHDFNGAFSLEESSSLGAAGGDTSDSKDSQQQQHQQHQHQQQA 215
            |. :|.|.|....|                                   |:::::..|   :.|.
Mouse   118 LEALLRGEGVEKKV-----------------------------------DAREEESIQ---EIQR 144

  Fly   216 VKEELLPKEWFYDDMDMNDVDSLEEPKSPADDEYDYDPRYGNKKRRKRRPGKRGGDSGGGGGGGG 280
            |.|              || :::||.....|.|.|.      .||:.|..|:..|.:||
Mouse   145 VLE--------------ND-ENVEEGNEEEDLEEDV------PKRKNRTRGRARGSAGG------ 182

  Fly   281 AGGGGNSGGSSSSRRRSAAA 300
                         |||..||
Mouse   183 -------------RRRHDAA 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	39/69 (57%)
Dpf3	NP_001254554.1	Requiem_N	13..84	CDD:372894	39/70 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..193		20/84 (24%)
		SFP1	<195..222	CDD:227516
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..254
		PHD1_DPF3	261..317	CDD:277162
		PHD2_d4	318..363	CDD:277005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846918
Domainoid	1	1.000	92	1.000	Domainoid score	I7580
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900