DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tth and PHF10

DIOPT Version :9

Sequence 1:	NP_001285216.1	Gene:	tth / 32318	FlyBaseID:	FBgn0030502	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_060758.2	Gene:	PHF10 / 55274	HGNCID:	18250	Length:	498	Species:	Homo sapiens

Alignment Length:	209	Identity:	41/209 - (19%)
Similarity:	74/209 - (35%)	Gaps:	47/209 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AKIESFLKDVSYRETIEYSANFNTRLCSERRHRLPFLDPQTGVAQNHSQLFLDKRQRMPGFRQGQ 80
            :|:..::|..: ::..|:::|.|.....|||   .:.|.||.|.|            :|   ||:
Human   194 SKVPEYIKKAA-KKAAEFNSNLNRERMEERR---AYFDLQTHVIQ------------VP---QGK 239

  Fly    81 IYTYPAARWRKSRRQYLSKMYSRFPERPFQALRKEHEALVASGVNLGLSSLTSGVGSMPGSNSLA 145
            ....|..|.:.|     |...:..|.: ||...|.:     |...|....|.:.:...|....|
Human   240 YKVLPTERTKVS-----SYPVALIPGQ-FQEYYKRY-----SPDELRYLPLNTALYEPPLDPEL- 292

  Fly   146 SSSSLTLNMLTGGGAAPAVLGSLHSDTAHDFNGAFSLEESSSLGAAGGDTSDSKDSQQQQHQQHQ 210
                            ||:.....||...|..|....:...:..::.|:.|:.:.....|....|
Human   293 ----------------PALDSDGDSDDGEDGRGDEKRKNKGTSDSSSGNVSEGESPPDSQEDSFQ 341

  Fly   211 HQQQAVKEELLPKE 224
            .:|::..:...|::
Human   342 GRQKSKDKAATPRK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	17/69 (25%)
PHF10	NP_060758.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		SAY	89..295		30/147 (20%)
		Essential to induce neural progenitor proliferation. /evidence=ECO:0000250	89..185
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..368		14/88 (16%)
		Essential to induce neural progenitor proliferation. /evidence=ECO:0000250	292..334		9/58 (16%)
		PHD1_PHF10	379..433	CDD:277003
		PHD2_PHF10	435..478	CDD:277004
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010