DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tth and RSF1

DIOPT Version :9

Sequence 1:	NP_001285216.1	Gene:	tth / 32318	FlyBaseID:	FBgn0030502	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_057662.3	Gene:	RSF1 / 51773	HGNCID:	18118	Length:	1441	Species:	Homo sapiens

Alignment Length:	358	Identity:	72/358 - (20%)
Similarity:	115/358 - (32%)	Gaps:	113/358 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LCSERRHRLPFLDPQTGVAQNHSQLFLDKRQRM---------------PGFRQGQIYTYPAARWR 90
            ||.:...:|..||    ||....:....:::|:               |.|.:.|......::..
Human   943 LCEKLEEQLQDLD----VALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKS 1003

  Fly    91 KSR---------RQYLSKMYSRFPERPFQALRKEHEALVASGVNLG--LSSLTSGVGSMPGS--- 141
            |:.         |:.:|..:..|.|...:|:..:.:.....||..|  :|::|...|....:
Human  1004 KANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILD 1068

  Fly   142 -----------------------NSLASSSSLTLN------MLTGGGAAPAVLGSLHSDTAHDFN 177
                                   |.|.|.|:|...      .::.|.....|:.        |.|
Human  1069 EERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVS--------DEN 1125

  Fly   178 GAFSLEESSSLGAAGGDTSDSK--DSQQQQHQQHQHQQQAVKEELLPKEWFYDDMDMNDVDSLEE 240
            ...|.|:..|     .|.||:.  ..:.::|.....:|........||:.:.||      |..||
Human  1126 PDESEEDPPS-----NDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDD------DEEEE 1179

  Fly   241 -PKSPADDEYDYDPRYGN-----KKRRKRRPGKR----GGDSGGGGGGGGAGGGGNSGGSSSSRR 295
             .::..|.|.|:...:.:     ::||.||..||    ..||             .|.||..|.|
Human  1180 SEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDS-------------ESDGSQKSLR 1231

  Fly   296 RSAAARSRITTTDAALDASLEAIESGESVPGSN 328
            |....| |:.      ...|.:.||.||....|
Human  1232 RGKEIR-RVH------KRRLSSSESEESYLSKN 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	12/76 (16%)
RSF1	NP_057662.3	WHIM1	98..148	CDD:292246
		WHIM2	150..182	CDD:292247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..283
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..634
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..887
		PHD_RSF1	893..938	CDD:277018
		BAH	915..>968	CDD:295389	7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1007		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1428		49/234 (21%)
		CDC45	1093..>1171	CDD:280821	18/90 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930