DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tth and dpf2l

DIOPT Version :9

Sequence 1:	NP_001285216.1	Gene:	tth / 32318	FlyBaseID:	FBgn0030502	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_997861.2	Gene:	dpf2l / 326933	ZFINID:	ZDB-GENE-030131-5132	Length:	405	Species:	Danio rerio

Alignment Length:	294	Identity:	84/294 - (28%)
Similarity:	123/294 - (41%)	Gaps:	86/294 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSAVNIQIVSMPNLAKIESFLKDVSYRETIEYSANFNTRLCSERRHRLPFLDPQTGVAQNHSQL 65
            |::||.       |:.|:   |.:..|::.:|...|:|.|||:||...:||||.||||||::..:
Zfish     1 MATAVE-------NIVKV---LGEQYYKDALEQCHNYNARLCAERSILMPFLDSQTGVAQSNCYI 55

  Fly    66 FLDKRQRMPGFRQGQIYTYPAARWRKSRRQYLSKMYSRFPERPFQALRKEHEALV-----ASGVN 125
            :::||.|..|...||:|:|||.||||.||.:.       ||.|         |||     .:.:.
Zfish    56 WMEKRHRSAGTAPGQLYSYPARRWRKKRRAHP-------PEDP---------ALVFPPLKTAELE 104

  Fly   126 LGLSSLTSGVGSMPGSNSLASSSSLTLNMLTGGGAAPAVLGSLHSDTAHDFNGAFSLEESSSLGA 190
            |||..  ..:|.:.||:..|        :|.|......|...|...           ||.:||..
Zfish   105 LGLKK--DVLGPLDGSSLEA--------LLKGEPLDKRVTTELRPP-----------EEETSLAE 148

  Fly   191 AGGDTSDSKDSQQQQHQQHQHQQQAVKEELLPKEWFYDDMDMNDVDSLEEPK------------- 242
            ..|.::.|..|...:          :::.:|..|.:.||:|..|.:. |.||
Zfish   149 ITGTSTASSHSGSTR----------IRKRILEPEDYLDDLDDEDFEE-ETPKRRSKGKSKGRGVG 202

  Fly   243 -------SPADDEYDYDPRYGNK---KRRKRRPG 266
                   :.|..:.|.|..|...   ||.|.|||
Zfish   203 NGKKKLEAAAAAQEDRDKPYACDICGKRYKNRPG 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	33/69 (48%)
dpf2l	NP_997861.2	Requiem_N	13..79	CDD:290758	29/65 (45%)
		Peptidase_C19	222..>244	CDD:271592	7/15 (47%)
		PHD1_DPF2_like	284..339	CDD:277161
		PHD2_d4	341..386	CDD:277005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592114
Domainoid	1	1.000	92	1.000	Domainoid score	I7563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm26601
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.900