DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tth and Rsf1

DIOPT Version :9

Sequence 1:	NP_001285216.1	Gene:	tth / 32318	FlyBaseID:	FBgn0030502	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_218939.4	Gene:	Rsf1 / 308839	RGDID:	1311245	Length:	1448	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	70/357 - (19%)
Similarity:	115/357 - (32%)	Gaps:	106/357 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LCSERRHRLPFLDPQTGVAQNHSQLFLDKRQRM---------------PGFRQGQIYTYPAARWR 90
            ||.:...:|..||    ||....:....:::|:               |.|.:.|......|:..
  Rat   947 LCEKLEEQLQDLD----VALKKKERAERRKERLVYVGISIENIIPPQEPEFSEDQEEKKKDAKKS 1007

  Fly    91 KSR---------RQYLSKMYSRFPERPFQALRKEHEALVASGVNLG--LSSLTSGVGSMPGS--- 141
            |:.         |:.:|..:..|.|...:|:..:.:.....||..|  :|::|...|....:
  Rat  1008 KANVLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILD 1072

  Fly   142 -----------------------NSLASSSSLTLN------MLTGGGAAPAVLGSLHSDTAHDFN 177
                                   |.|.|.|:|...      .::.|.....|:.        |.|
  Rat  1073 EERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVS--------DEN 1129

  Fly   178 GAFSLEESSSLGAAGGDTSDSK--DSQQQQHQQHQHQQQAVKEELLPKEWFYDDMDMNDVDSLEE 240
            ...|.||..|     .:.||:.  ..:.::|.....:|.........|:.:.||.:..:.:..|.
  Rat  1130 PDESEEEPPS-----NEDSDTDFCSRRLRRHPSRPMRQSRRLRRKTQKKKYSDDDEEEEEEEEES 1189

  Fly   241 PKSPADDEYDYDPRYGN-----KKRRKRRPGKR----GGDSGGGGGGGGAGGGGNSGGSSSSRRR 296
            .::..|.|.|:...:.:     ::||.||..||    ..||             .|.||..|.||
  Rat  1190 EENSRDSESDFSDDFSDEFVETRRRRSRRNQKRQINYKEDS-------------ESDGSQKSLRR 1241

  Fly   297 SAAARSRITTTDAALDASLEAIESGESVPGSN 328
            ....| |:.      ...|.:.||.||....|
  Rat  1242 GKEIR-RVH------KRRLSSSESEESYMSKN 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	13/76 (17%)
Rsf1	XP_218939.4	WHIM1	102..152	CDD:292246
		WHIM2	154..186	CDD:292247
		PHD_RSF1	897..942	CDD:277018
		BAH	919..>972	CDD:295389	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930