Protein Alignment tth and Kat6a

DIOPT Version :9

• Sequence 1: NP_001285216.1
• Gene: tth / 32318
• FlyBaseID: FBgn0030502
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_001094040.1
• Gene: Kat6a / 306571
• RGDID: 1304892
• Length: 1998
• Species: Rattus norvegicus
• Alignment Length: 276
• Identity: 55/276 - (19%)
• Similarity: 95/276 - (34%)
• Gaps: 72/276 - (26%)

  Fly    62 HSQLFLDKRQRMPGFRQGQIYTYPAARWRKSRRQYLS-----KMYSRFPERPFQALRKEHEALVA 121
            ||:|.|:..|.:....|.:...:..|  .:...:.|:     :.|:...|.|..::.::..|
  Rat  1410 HSELDLETVQAVQSLTQEESSEHEGA--YQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHA--- 1469

  Fly   122 SGVNLGLSSLTSGVGSMPG--SNSLASSSSLTLNMLTGG--GAAPAVLGSLHSDTAHDFNGAFSL 182
                   |...|.:.|:|.  |.|:.|.||.::..|..|  ..:|. .|||.:.:..      ::
  Rat  1470 -------SEHNSPISSIPSHPSQSVRSVSSPSMPALESGYTQISPE-QGSLSAPSMQ------NM 1520

  Fly   183 EESSSLGAAGGDTSDSKDSQQQQHQQHQHQQQAVKEELLPKEWFYDDMDMNDVDSLEEPKSPADD 247
            |.|..:     |.....|          |.||.|            |...:|:.|:|......::
  Rat  1521 ETSPMM-----DVPSVSD----------HSQQVV------------DSGFSDLGSIESTTENYEN 1558

  Fly   248 EYDYDPRYGNKKRRKRRPGKRGGDSGGGGGGGGAGGGGNSGGSSSSRRRSAAARSRITTTDAALD 312
            ...||...|:            ...|..........||.|  ||||..:::..   :|...|::.
  Rat  1559 PSSYDSTMGS------------SICGNNSSQSSCSYGGLS--SSSSLTQNSCV---VTQQMASMG 1606

  Fly   313 ASLEAIESGESVPGSN 328
            .|...::.....|.:|
  Rat  1607 NSCSMLQQNSVQPATN 1622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tth	NP_001285216.1	Requiem_N	24..94	CDD:290758	7/31 (23%)
Kat6a	NP_001094040.1	Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794	1..144
		Required for nuclear localization. /evidence=ECO:0000250	52..166
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..93
		H15	85..162	CDD:197772
		Interaction with PML. /evidence=ECO:0000250	144..662
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..662
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..377
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..464
		Catalytic. /evidence=ECO:0000250	486..776
		PLN00104	<502..776	CDD:215056
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	505..808
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794	643..647
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794	652..658
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	982..1079
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1175
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1195..1436		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1450..1567		33/160 (21%)
		Interaction with PML. /evidence=ECO:0000250	1510..1735		31/163 (19%)
		Interaction with RUNX1-2. /evidence=ECO:0000250	1510..1635		31/163 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1630..1702
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1907..1942

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930