Protein Alignment Ndc80 and NDC80

DIOPT Version :10

• Sequence 1: NP_572902.1
• Gene: Ndc80 / 32316
• FlyBaseID: FBgn0030500
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_012122.3
• Gene: NDC80 / 854662
• SGDID: S000001406
• Length: 691
• Species: Saccharomyces cerevisiae
• Alignment Length: 725
• Identity: 144/725 - (19%)
• Similarity: 283/725 - (39%)
• Gaps: 139/725 - (19%)

  Fly     1 MSHLMPRR-TSEF---RGDVLEERGTADKRQTRATKRSAATHTPS----------------SSQA 45
            :.|:.|.| ||:.   ....|..|.:.::..|....:|.|.:|.|                |:.|
Yeast    12 LHHMDPHRFTSQIPTATSSQLRRRNSTNQGLTDMINKSIARNTISGTGIPTGGINKNKRTRSTVA 76

  Fly    46 APRRPSASRLPQPLN----LERDRASQMGVTPKRGHRFVPSTAERAIAPHSDKKWVAERAQQILE 106
            .....:|..|....|    :.|...:|:|...:.       .:.|...|..||.:.:...::|.:
Yeast    77 GGTNGTALALNDKSNSRNSVSRLSINQLGSLQQH-------LSNRDPRPLRDKNFQSAIQEEIYD 134

  Fly   107 YLHGIQNSEAPTGLIADLFSRPGGLRHMTIKQFVSILNFMFHHIWRNRVTVGQNHVE----DITS 167
            ||...:........|:..|     |:..|.|.|:.|..:::     .|:..|....:    :|..
Yeast   135 YLKKNKFDIETNHPISIKF-----LKQPTQKGFIIIFKWLY-----LRLDPGYGFTKSIENEIYQ 189

  Fly   168 AMQKLQYPY--QVNKSWL--VSPTTQHSF-G--HVIVLLDFLMDFLPPLPSSDVVEEEFPFMETM 225
            .::.|:||:  .:|||.:  |..:..|.| |  |.:|..:..:|.........::.:....:..:
Yeast   190 ILKNLRYPFLESINKSQISAVGGSNWHKFLGMLHWMVRTNIKLDMCLNKVDRSLINQNTQEITIL 254

  Fly   226 EQPSSYLNSMHCESTTIMSTTQAHAIQLDEDVNGLLFEEASKCIALWDQ-ELTNEEAKLQAETRD 289
            .||...|:...       ...:.:.:.:::.:.....|.....:.|.|. |.:.:|.||..|...
Yeast   255 SQPLKTLDEQD-------QRQERYELMVEKLLIDYFTESYKSFLKLEDNYEPSMQELKLGFEKFV 312

  Fly   290 QVISKKCDLPDRKALDQLIGDLKTKLQQLENKLHDPSEDNKL-----NKLERLTKEHDQLAQQLA 349
            .:|:  .|:.:.:..:..:.:...::.::..|:....|..|.     ||.|.......|.:|:..
Yeast   313 HIIN--TDIANLQTQNDNLYEKYQEVMKISQKIKTTREKWKALKSDSNKYENYVNAMKQKSQEWP 375

  Fly   350 ASEEELIKKLKLYEQLSAQVEEKQSNLRQQMKYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYS 414
            ...|::..:.:|.|:   :::..|||:.:       |.:.:.::..|.:|. |||         :
Yeast   376 GKLEKMKSECELKEE---EIKALQSNISE-------LHKILRKKGISTEQF-ELQ---------N 420

  Fly   415 KAYERQVKEVSELELHQQVMLSRAKQKQLDSVEVFNSHVRHL-SMDPVICGLIKSGIGQQSDLTL 478
            :..|:..:|:.::.:....:.|..|.::|::..:|.|.:..| ..|..|..|.:|        ..
Yeast   421 QEREKLTRELDKINIQSDKLTSSIKSRKLEAEGIFKSLLDTLRQYDSSIQNLTRS--------RS 477

  Fly   479 PLNPNQEDISERVQCLELLGKLLQQHRQQNIDRRQMLDKQVA---KVKSDSIELDTEIATMDSQL 540
            .|..|..|.|.::...|   .||.:...:.|...|:..|...   .:|...::|:.||
Yeast   478 QLGHNVNDSSLKINISE---NLLDRDFHEGISYEQLFPKGSGINESIKKSILKLNDEI------- 532

  Fly   541 RAQKQRLTKMEASYRT-KRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLL 604
               ::|:..:|....| ::|:     :.|..|..::|...::||....:|..|.|.|||.||.||
Yeast   533 ---QERIKTIEKDNITLEKDI-----KNLKHDINEKTQINEKLELELSEANSKFELSKQENERLL 589

  Fly   605 TAAEQFQEQDLKARQDRLEKCEQKLAKAEDQLLAVESK-------VNATQAKLNEVEQKVYSAKL 662
            .           |::..:||.|:|:   .|..|.:::|       |.:|:.||.|::..:...:.
Yeast   590 V-----------AQRIEIEKMEKKI---NDSNLLMKTKISDAEELVTSTELKLEELKVDLNRKRY 640

  Fly   663 PSFQPVLDAI 672
            ...|.|:..|
Yeast   641 KLHQQVIHVI 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	48..204	CDD:461058	35/170 (21%)
		SMC_N	310..>661	CDD:481474	78/367 (21%)
NDC80	NP_012122.3	Ndc80_HEC	91..247	CDD:461058	34/172 (20%)
		SMC_prok_B	<241..621	CDD:274008	86/448 (19%)