Protein Alignment Ndc80 and ndc80

DIOPT Version :10

• Sequence 1: NP_572902.1
• Gene: Ndc80 / 32316
• FlyBaseID: FBgn0030500
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001003863.1
• Gene: ndc80 / 445386
• ZFINID: ZDB-GENE-030131-904
• Length: 632
• Species: Danio rerio
• Alignment Length: 713
• Identity: 146/713 - (20%)
• Similarity: 273/713 - (38%)
• Gaps: 196/713 - (27%)

  Fly    48 RRPSASRLPQPLNLERDRASQMGVTPKR-----GHRFVP----STAERAIA-------------- 89
            ||||:.....|:.:...|.|.:..||:.     |...:|    :|:||..:
Zfish     3 RRPSSRYSEMPMRVTDSRMSLINATPQNKDNAFGKLNIPKPQSTTSERRTSFFGKGIGAGGQRNS 67

  Fly    90 -------------PHS--DKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPG-----GLRHM 134
                         |.:  ||.:|.:..:|:.|:|       ...|.       ||     .|:..
Zfish    68 MFGSYGGSEKMKDPRALHDKAFVQQCIKQLYEFL-------VDRGF-------PGSITVKALQSP 118

  Fly   135 TIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFGHVIVLL 199
            :.|:|:.|..|:::.:..:.........|:|...::.|.||:.::||.:.|....|::...:..|
Zfish   119 STKEFLKIYEFIYNFLEPSFQMPTAKVEEEIPRMLKDLGYPFALSKSSMYSIGAPHTWPLALGAL 183

  Fly   200 DFLMDFL--------PPLPSSDVVEEEFPFMETMEQPSSY--LNSMHCESTTIMSTTQAHAIQLD 254
            .:|||.:        ..|..||..:|    :..:|..:.|  |...:|..|  .:.....|...|
Zfish   184 IWLMDAVKLFGGQREQDLLFSDFSDE----LCDLEDRTEYNKLIMEYCSDT--YNKFMQGADTFD 242

  Fly   255 EDVNGLLFEEASKCIALWDQELTN-EEAKL--QAETRDQVISKKCDLPDRKALDQLIGD------ 310
            ::.:..|::.         ::|.| :||.|  |.|....::.....|......|:|:|.
Zfish   243 DEDDDFLYKL---------KKLYNVDEALLHSQQEKHSMLMEHVERLERESQTDRLVGKRTEKLR 298

  Fly   311 LKTKLQQLEN-----KLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLYEQLSAQVE 370
            |:|.||:|:|     :.|....:|                           |...|.|:|.| ||
Zfish   299 LQTDLQKLQNYRCTLEAHKTGLEN---------------------------KSAGLTEELEA-VE 335

  Fly   371 EKQSNLRQQMKYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQVKEVSELELHQQVML 435
            .:...|:|:   ..||:..:..|||:...::.:..:.::::.......:.::|..:|..:::|.|
Zfish   336 MQLEGLKQE---RTRLQHILENQKFTPADIERINRERNELQQTIHGLSQSLEEGEQLVWNEEVNL 397

  Fly   436 SRAKQKQLDSVEVFNSHVRHLSMDPV----ICG--------LIKSGIGQ-QSDLTLPLNPNQEDI 487
            |:.|:|....|..:|...|.|.:.|:    .||        ...:.|.| ::.:..||.....::
Zfish   398 SKTKEKAELKVAEYNKLGRKLKLIPLSAENACGHDFEIRADYSATTITQYKTQIQNPLKNMMVEV 462

  Fly   488 SERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEA 552
            .|...            |..|::  ..|::.|.:|||:..:.:.:|..:..|:|...|:|.
Zfish   463 EEEFS------------RLSNVN--LSLEETVEQVKSNIFDKENDIKQLKEQIRKVDQQLE---- 509

  Fly   553 SYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEK--LEASKQRNEDLLTAAEQF----Q 611
                    .|.....|.:|::  .|.||..| ..|:..||  ::..::..|::..|.:|:    |
Zfish   510 --------NAMQEMALEDDKW--AAELDSAE-THKKLFEKNVMQGIEEAEEEVKAAQQQYHVVVQ 563

  Fly   612 EQDLKARQ----------------DRLEK-CEQKLAKAEDQLLAVESKVNATQAKLNEVEQKV 657
            |.:.|.|.                ..:|| |:::| |..|:|..:   |...:|.:|::...|
Zfish   564 ETNEKNRMVVKNMTDLFSSTVNHLFAVEKHCDEQL-KRFDKLKDI---VREDEADINQLTDLV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	48..204	CDD:461058	40/198 (20%)
		SMC_N	310..>661	CDD:481474	81/395 (21%)
ndc80	NP_001003863.1	Ndc80_HEC	49..205	CDD:461058	31/169 (18%)
		DUF5595	212..283	CDD:465636	16/81 (20%)
		SMC_prok_B	290..>622	CDD:274008	81/395 (21%)