DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndc80 and ndc80

DIOPT Version :9

Sequence 1:	NP_572902.1	Gene:	Ndc80 / 32316	FlyBaseID:	FBgn0030500	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001003863.1	Gene:	ndc80 / 445386	ZFINID:	ZDB-GENE-030131-904	Length:	632	Species:	Danio rerio

Alignment Length:	713	Identity:	146/713 - (20%)
Similarity:	273/713 - (38%)	Gaps:	196/713 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RRPSASRLPQPLNLERDRASQMGVTPKR-----GHRFVP----STAERAIA-------------- 89
            ||||:.....|:.:...|.|.:..||:.     |...:|    :|:||..:
Zfish     3 RRPSSRYSEMPMRVTDSRMSLINATPQNKDNAFGKLNIPKPQSTTSERRTSFFGKGIGAGGQRNS 67

  Fly    90 -------------PHS--DKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPG-----GLRHM 134
                         |.:  ||.:|.:..:|:.|:|       ...|.       ||     .|:..
Zfish    68 MFGSYGGSEKMKDPRALHDKAFVQQCIKQLYEFL-------VDRGF-------PGSITVKALQSP 118

  Fly   135 TIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFGHVIVLL 199
            :.|:|:.|..|:::.:..:.........|:|...::.|.||:.::||.:.|....|::...:..|
Zfish   119 STKEFLKIYEFIYNFLEPSFQMPTAKVEEEIPRMLKDLGYPFALSKSSMYSIGAPHTWPLALGAL 183

  Fly   200 DFLMDFL--------PPLPSSDVVEEEFPFMETMEQPSSY--LNSMHCESTTIMSTTQAHAIQLD 254
            .:|||.:        ..|..||..:|    :..:|..:.|  |...:|..|  .:.....|...|
Zfish   184 IWLMDAVKLFGGQREQDLLFSDFSDE----LCDLEDRTEYNKLIMEYCSDT--YNKFMQGADTFD 242

  Fly   255 EDVNGLLFEEASKCIALWDQELTN-EEAKL--QAETRDQVISKKCDLPDRKALDQLIGD------ 310
            ::.:..|::.         ::|.| :||.|  |.|....::.....|......|:|:|.
Zfish   243 DEDDDFLYKL---------KKLYNVDEALLHSQQEKHSMLMEHVERLERESQTDRLVGKRTEKLR 298

  Fly   311 LKTKLQQLEN-----KLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLYEQLSAQVE 370
            |:|.||:|:|     :.|....:|                           |...|.|:|.| ||
Zfish   299 LQTDLQKLQNYRCTLEAHKTGLEN---------------------------KSAGLTEELEA-VE 335

  Fly   371 EKQSNLRQQMKYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQVKEVSELELHQQVML 435
            .:...|:|:   ..||:..:..|||:...::.:..:.::::.......:.::|..:|..:::|.|
Zfish   336 MQLEGLKQE---RTRLQHILENQKFTPADIERINRERNELQQTIHGLSQSLEEGEQLVWNEEVNL 397

  Fly   436 SRAKQKQLDSVEVFNSHVRHLSMDPV----ICG--------LIKSGIGQ-QSDLTLPLNPNQEDI 487
            |:.|:|....|..:|...|.|.:.|:    .||        ...:.|.| ::.:..||.....::
Zfish   398 SKTKEKAELKVAEYNKLGRKLKLIPLSAENACGHDFEIRADYSATTITQYKTQIQNPLKNMMVEV 462

  Fly   488 SERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEA 552
            .|...            |..|::  ..|::.|.:|||:..:.:.:|..:..|:|...|:|.
Zfish   463 EEEFS------------RLSNVN--LSLEETVEQVKSNIFDKENDIKQLKEQIRKVDQQLE---- 509

  Fly   553 SYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEK--LEASKQRNEDLLTAAEQF----Q 611
                    .|.....|.:|::  .|.||..| ..|:..||  ::..::..|::..|.:|:    |
Zfish   510 --------NAMQEMALEDDKW--AAELDSAE-THKKLFEKNVMQGIEEAEEEVKAAQQQYHVVVQ 563

  Fly   612 EQDLKARQ----------------DRLEK-CEQKLAKAEDQLLAVESKVNATQAKLNEVEQKV 657
            |.:.|.|.                ..:|| |:::| |..|:|..:   |...:|.:|::...|
Zfish   564 ETNEKNRMVVKNMTDLFSSTVNHLFAVEKHCDEQL-KRFDKLKDI---VREDEADINQLTDLV 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	63..204	CDD:281754	35/183 (19%)
ndc80	NP_001003863.1	Ndc80_HEC	49..203	CDD:281754	31/167 (19%)
ndc80	NP_001003863.1	RILP-like	<270..377	CDD:304877	26/137 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55244
OrthoDB	1	1.010	-	-		D364574at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930