Protein Alignment Ndc80 and LAMA2

DIOPT Version :10

• Sequence 1: NP_572902.1
• Gene: Ndc80 / 32316
• FlyBaseID: FBgn0030500
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_000417.3
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3122
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 110/554 - (19%)
• Similarity: 211/554 - (38%)
• Gaps: 172/554 - (31%)

  Fly   208 PLPSSDVVEEEFPF-----METMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDVNGLLFEEASK 267
            |||:        |:     :|.|.|...:|.|.......::...:.:...|..::|.|| ..|:|
Human  1601 PLPA--------PYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELL-TRATK 1656

  Fly   268 CIALWDQELTNEEAKLQAETRDQVISKKCDLPDRKALDQLIGDLKTKLQQLENKLHDPSEDNKLN 332
            ..|  |.|.|.::|: :..||            .|:|.:.|.:|....:.:..|.      .|||
Human  1657 VTA--DGEQTGQDAE-RTNTR------------AKSLGEFIKELARDAEAVNEKA------IKLN 1700

  Fly   333 K------------LERLTKEHDQLAQQL---------------AASEEELIKKL-KLYEQLSAQV 369
            :            ||.|.||.||:.::|               ..:.|.|:||: ||:.:...:.
Human  1701 ETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGEN 1765

  Fly   370 EEKQSNLRQQM-KYEKRLEQAVNRQKFSAQQLKE--------------LQMKCDDMENYSKAYER 419
            ||.:.:||::: .|:.:::.|.:..:.:..:::|              |:.|.:.:|:..:..|.
Human  1766 EEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIEN 1830

  Fly   420 QVKEVSELELHQQVMLSRAKQKQLDSVEVFNSHVRHLSMDPVICGLIKSGIGQQSDLTLPLNPNQ 484
            .:||.:::       |..|.:                     :...|.|.|....|:...|.|..
Human  1831 TLKEGNDI-------LDEANR---------------------LADEINSIIDYVEDIQTKLPPMS 1867

  Fly   485 EDISERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTK 549
            |::::::..|           .|.|..|::.:| |::.:|.:.:|:...|.:|..|...|.....
Human  1868 EELNDKIDDL-----------SQEIKDRKLAEK-VSQAESHAAQLNDSSAVLDGILDEAKNISFN 1920

  Fly   550 MEASYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKL-EASK---------------- 597
            ..|:::...:::          .|     :||.||..|:|.:.. ||:|
Human  1921 ATAAFKAYSNIK----------DY-----IDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGC 1970

  Fly   598 -QRNEDLLTAAEQFQEQDLKARQDRLEKCEQKLAKAE-----------DQLLAVESKVNATQAKL 650
             |::..:|..|::. ..|:|..:|.|...:.::..|:           |.|..:.:..|.|.|||
Human  1971 LQKSFRILNEAKKL-ANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKL 2034

  Fly   651 NEVEQKVYS---------AKLPSFQPVLDAIKNH 675
            ..|:.|...         |::......||.:|.:
Human  2035 QAVKDKARQANDTAKDVLAQITELHQNLDGLKKN 2068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	48..204	CDD:461058
		SMC_N	310..>661	CDD:481474	81/431 (19%)
LAMA2	NP_000417.3	LamNT	37..285	CDD:214532
		EGF_Lam	287..334	CDD:238012
		Laminin_EGF	414..471	CDD:395007
		Laminin_EGF	469..515	CDD:395007
		LamB	578..710	CDD:214597
		EGF_Lam	756..805	CDD:238012
		Laminin_EGF	807..862	CDD:395007
		EGF_Lam	864..916	CDD:238012
		EGF_Lam	917..965	CDD:238012
		EGF_Lam	967..1011	CDD:214543
		EGF_Lam	1014..1057	CDD:214543
		Laminin_EGF	1060..1108	CDD:395007
		Laminin_EGF	1106..1163	CDD:395007
		LamB	1229..1364	CDD:214597
		Laminin_EGF	1420..1466	CDD:395007
		Laminin_EGF	1469..1524	CDD:395007
		EGF_Lam	1527..1574	CDD:238012
		Domain II and I	1574..2144		110/554 (20%)
		Laminin_I	1593..1852	CDD:310534	60/308 (19%)
		SMC_prok_B	1718..>2077	CDD:274008	77/407 (19%)
		Laminin_II	2037..2173	CDD:368703	6/32 (19%)
		Laminin_G_1	2174..2314	CDD:395008
		Laminin_G_1	2368..2507	CDD:395008
		Laminin_G_1	2554..2695	CDD:395008
		Laminin_G_1	2793..2921	CDD:395008
		LamG	2941..3093	CDD:238058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3043..3063