Protein Alignment Ndc80 and Ndc80

DIOPT Version :10

• Sequence 1: NP_572902.1
• Gene: Ndc80 / 32316
• FlyBaseID: FBgn0030500
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001119742.2
• Gene: Ndc80 / 301701
• RGDID: 1310154
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 706
• Identity: 143/706 - (20%)
• Similarity: 289/706 - (40%)
• Gaps: 172/706 - (24%)

  Fly    11 EFRGDVLEERG--TADKRQTRATKRSAATHTPSSSQAAPRRPSASRLPQPLNLERDRASQMGVTP 73
            |.|...|.:.|  |...|: |:|....:||.|:|.:      ..|...:..:....|.||:|:
  Rat    18 ELRSLDLNKPGLHTPQTRE-RSTFGKLSTHKPTSER------KVSIFGKRTSEHGSRNSQLGI-- 73

  Fly    74 KRGHRFVPSTAERAIAPHSDKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPGGLRHMTIKQ 138
                 |..|...:...|.:||.::.:..:|:.|:|       ...|.:..:..:  .|:..:.|.
  Rat    74 -----FSSSEKIKDPRPLNDKAFIQQCIRQLYEFL-------TENGYVYSVSMK--SLQAPSTKD 124

  Fly   139 FVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFGHVIVLLDFLM 203
            |:.|..|::..:..:.........|::....::|.||:.::||.:.:....|::.|::..|.:|.
  Rat   125 FLKIFAFLYGFLCPSYELPDTKCEEEVPRIFKELGYPFALSKSSMYTVGAPHTWPHIVAALVWLT 189

  Fly   204 DFLPPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDV--NGLLFEEAS 266
            |.:             ...:.|:|           |:.:....||...:.::.:  |.|..:...
  Rat   190 DCI-------------KIHDAMKQ-----------SSPLFDDGQAWGEETEDGIKHNKLFLDYTK 230

  Fly   267 KCIALWDQELT------NEEAKLQAETRD--QVISKKCD--LPDRKALDQLIGDLKTKLQQLENK 321
            ||   :::.:|      :.:|:|||:.:|  :|.:.|.:  :.:.|||::.|    .:|:|...|
  Rat   231 KC---YEKFMTGADTFEDVDAELQAKLKDLYKVDASKLESLVEENKALNEQI----ARLEQEREK 288

  Fly   322 LHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLY----EQLSAQVEEKQSNLRQQ--- 379
                 |.|:|..|           ::|.||.:..::..|.|    |..|:.:|:|.|:|.::
  Rat   289 -----EPNRLISL-----------RKLKASLQADVQNYKAYMSNLESHSSILEQKLSSLDEEIGR 337

  Fly   380 -------MKYEK-RLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQV--KEVSELELHQQVM 434
                   :|.|. ||:..|:.||:|...::.:        |:.|...:|.  |...:||..||.|
  Rat   338 LELECETVKQENTRLQSVVDNQKYSIADIERI--------NHEKNELQQTINKLTKDLEAEQQQM 394

  Fly   435 ----LSRAKQKQLDSVEVFNSH--VRHLSMDPVICGLIKSGIGQQS-DLTLPLNPNQED---ISE 489
                |..|:.|:....::...|  .|.|.:.|      |.....:. |..:..||....   :..
  Rat   395 WNEELKYARGKEAIEAQLAEYHKLARKLKLIP------KGAENSKGYDFEIKFNPEAGANCLVKY 453

  Fly   490 RVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEASY 554
            |.|....|.:||.:           :::::.|..:..:.|:..:..::: ::.:.:|..:|
  Rat   454 RTQVYAPLKELLNE-----------IEEEINKALNKKMGLEDTLEQLNT-VKTESKRAVRM---- 502

  Fly   555 RTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLLTAAEQFQEQDLKARQ 619
             .|.::|.      |:|.|.|  ::.|.|:.:|:...:|: |.::::.||.:|
  Rat   503 -LKEEVQK------LDDLYQQ--KVKEAEEEDKKCASELD-SLEKHKHLLESA------------ 545

  Fly   620 DRLEKCEQKLAKAEDQLLAVESKVNATQAKLNEVEQKVYSAKLPSFQPVLDAIKNH 675
                 ..:.|::|..:|.||:.:.........|..:||.:    :.|.:|:.:..|
  Rat   546 -----VNEGLSEAMGELDAVQREYQLAVQTTTEERRKVGN----NLQRLLEMVATH 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	48..204	CDD:461058	29/155 (19%)
		SMC_N	310..>661	CDD:481474	77/377 (20%)
Ndc80	NP_001119742.2	Ndc80_HEC	51..206	CDD:461058	27/154 (18%)
		DUF5595	213..285	CDD:465636	10/79 (13%)
		SMC_prok_B	249..>575	CDD:274008	75/364 (21%)