Protein Alignment Ndc80 and ndc-80

DIOPT Version :9

• Sequence 1: NP_572902.1
• Gene: Ndc80 / 32316
• FlyBaseID: FBgn0030500
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_501830.1
• Gene: ndc-80 / 177873
• WormBaseID: WBGene00003576
• Length: 590
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 149/690 - (21%)
• Similarity: 257/690 - (37%)
• Gaps: 176/690 - (25%)

  Fly    24 DKRQT-------RA------TKRSAATHTPSSSQAAPRRPSASRLPQPLNLERDRASQMGVTPKR 75
            |:|:|       ||      |||.......:|.:....|||   |.||      |.|..
 Worm     4 DRRKTGGLNLNGRASIAITPTKRFTDYTGSTSVRKTDARPS---LSQP------RVSLF------ 53

  Fly    76 GHRFVPSTAERAIAPHSDKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPGGLRHMTIKQFV 140
                  :|...::||...|..|:....:|..:|...::|:||:   ..|..:|.|.     ..|:
 Worm    54 ------NTKNSSVAPRDVKSLVSLNGSKIYNFLVEYESSDAPS---EQLIMKPRGK-----NDFI 104

  Fly   141 SILNFMFHHIWRNRVTVGQNHVEDITSAMQK-LQYPYQVNKSWLVSPTTQHSFGHVIVLLDFLMD 204
            :....::.|:.::........:|:..|.:.| |.|||.:..|:.....:.|.:.|::..|.:|:|
 Worm   105 ACFELIYQHLSKDYEFPRHERIEEEVSQIFKGLGYPYPLKNSYYQPMGSSHGYPHLLDALSWLID 169

  Fly   205 FLPPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDVNGLL---FEEAS 266
            .:                        .:||                 .:.||...:|   |.|..
 Worm   170 II------------------------RINS-----------------AVSEDTQNILFGDFMEQG 193

  Fly   267 KCIALWDQELTNEEAKLQAETRDQVISKKCDLPDRKALD----QLIGDLKTKLQ---QLENKLHD 324
            |.     ||.|...|.:.:..||..       .||||.:    ....|.|.:|:   :..|:..|
 Worm   194 KA-----QEKTLNYAWMTSTFRDYT-------NDRKAAENPSSSYWDDTKHRLRKYFEQSNEFED 246

  Fly   325 PSEDNKLNKLERLTKEHDQLAQQL---AASEEEL------IKKLKLYEQLSAQVEEKQSNLRQQM 380
            .:: ...:.||.|..|.|::....   |:.:||:      |:|.|.|         .:.||..:.
 Worm   247 MTK-TAASALEMLNYECDEIEADKGNEASLKEEISRIRDDIRKAKDY---------LEQNLHVKQ 301

  Fly   381 KYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQV-----KEVSELELHQ--------- 431
            ..||.|....:.|:....:.:::|...||::|..: .::|:     |||.::.|..
 Worm   302 HMEKELAMVKSEQEEKISENEKVQKMVDDLKNKIE-LQKQIHGLTGKEVRQMNLDNNKDKEVVLE 365

  Fly   432 -QVMLSRA-----KQKQLDSVEVFNSHVRHLSMDPVICGLIKSGIGQQSDLTLPLN--PNQEDIS 488
             |..|.|.     |.|..|..:...|...||:...:   .|.||:..|.:|. ||.  .|:.|:.
 Worm   366 IQSELDRLSKETWKLKDEDFFKEQKSKFIHLAEQIM---KILSGLNIQMNLE-PLRAPTNERDLK 426

  Fly   489 ERVQCLELLGKLLQQHRQQNIDRRQM-LDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEA 552
            :   ..|.|.|:......:.:.:|:: |:.:.::..:.::..:..|......|...|:...:.|.
 Worm   427 D---YWETLNKIWVPEISRQLHQRKLELETEQSRFSNKAVTAEERIQIQSETLCEAKKNEAREER 488

  Fly   553 SYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRN-EDLLTAAEQFQEQDLK 616
            ..|.:||.....|:. :|.:|:|.  |:|.|...||.  ||:.|.::. ||.........|:.::
 Worm   489 IRRNERDSWKDARKH-IEQRYEQL--LNEKEVLLKQM--KLDGSLEKEIEDETARMSATGEEHIQ 548

  Fly   617 ARQDRLEKCEQKLAKAEDQLLAVESKVNATQAKLNEVEQK 656
            .|........|.|     .|:.||         :.|:|.|
 Worm   549 KRSQLEAGIRQIL-----DLMVVE---------IAEIENK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	63..204	CDD:281754	29/141 (21%)
ndc-80	NP_501830.1	Ndc80_HEC	42..180	CDD:281754	38/207 (18%)
		HEC1	76..>469	CDD:227512	96/471 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8534
eggNOG	1	0.900	-	-		E1_COG5185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I4018
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55244
OrthoDB	1	1.010	-	-		D364574at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10643
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070