DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndc80 and NDC80

DIOPT Version :9

Sequence 1:	NP_572902.1	Gene:	Ndc80 / 32316	FlyBaseID:	FBgn0030500	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_006092.1	Gene:	NDC80 / 10403	HGNCID:	16909	Length:	642	Species:	Homo sapiens

Alignment Length:	712	Identity:	139/712 - (19%)
Similarity:	283/712 - (39%)	Gaps:	184/712 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EFRGDVLEERGTADKRQTRATKRSAATHTPSSSQAAPRRPSASR----LPQPLNLERDRASQMGV 71
            |.|...:.::|.    .|..||..     |:..:.:..:|::.|    ..:..:....|.||:|:
Human    18 ELRSQDVNKQGL----YTPQTKEK-----PTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGI 73

  Fly    72 TPKRGHRFVPSTAERAIAPHSDKKWVAERAQQILEYL------HGI--QNSEAPTGLIADLFSRP 128
                   |..|...:...|.:||.::.:..:|:.|:|      |.:  ::.:||
Human    74 -------FSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAP----------- 120

  Fly   129 GGLRHMTIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFG 193
                  ::|.|:.|..|::..:..:.........|::....:.|.||:.::||.:.:....|::.
Human   121 ------SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWP 179

  Fly   194 HVIVLLDFLMDFL----PPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLD 254
            |::..|.:|:|.:    ....||.:.::..|:.|..|.     ..||
Human   180 HIVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETED-----GIMH------------------ 221

  Fly   255 EDVNGLLFEEASKCIALWDQELTNEE------AKLQAETRDQVISKKCDLPDRKALDQLIGDLKT 313
               |.|..:...||   ::..::..:      |:||::.:|........|...:|.::.:.:...
Human   222 ---NKLFLDYTIKC---YESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIA 280

  Fly   314 KLQQLENKLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLY----EQLSAQVEEKQS 374
            :|:|...|  :|      |:||.|.|        |.||.:..::|.:.|    |..||.:::|.:
Human   281 RLEQEREK--EP------NRLESLRK--------LKASLQGDVQKYQAYMSNLESHSAILDQKLN 329

  Fly   375 NLRQQ----------MKYEK-RLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQVKEVSELE 428
            .|.::          :|.|. ||:..::.||:|...::.:..:.::::....      |...:||
Human   330 GLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTIN------KLTKDLE 388

  Fly   429 LHQQVM----LSRAKQKQLDSVEVFNSH--VRHLSMDPVICGLIKSGIGQQS-DLTLPLNPNQED 486
            ..||.:    |..|:.|:....::...|  .|.|.:.|      |.....:. |..:..||....
Human   389 AEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIP------KGAENSKGYDFEIKFNPEAGA 447

  Fly   487 ---ISERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLT 548
               :..|.|....|.:||.: .::.|::  .|:|::.  ..|::|          ||.|.   :|
Human   448 NCLVKYRAQVYVPLKELLNE-TEEEINK--ALNKKMG--LEDTLE----------QLNAM---IT 494

  Fly   549 KMEASYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLLTAAEQFQEQ 613
            :.:.|.||.::     ..|.|:|.|.|  ::.|.|:.:::...:|| |.::::.||.:.
Human   495 ESKRSVRTLKE-----EVQKLDDLYQQ--KIKEAEEEDEKCASELE-SLEKHKHLLEST------ 545

  Fly   614 DLKARQDRLEKCEQKLAKAEDQLLAVESKVNATQAKLNEVEQKVYSAKLPSFQPVLDAIKNH 675
                       ..|.|::|.::|.||:.:.........|..:||.:    :.|.:|:.:..|
Human   546 -----------VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGN----NLQRLLEMVATH 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	63..204	CDD:281754	29/148 (20%)
NDC80	NP_006092.1	Interaction with the N-terminus of CDCA1	1..445		98/516 (19%)
		Nuclear localization	1..250		51/293 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74		13/71 (18%)
		Ndc80_HEC	51..206	CDD:309070	33/178 (19%)
		Interaction with RB1	128..251		25/151 (17%)
		SMC_N	<238..633	CDD:330553	89/430 (21%)
		Interaction with NEK2 and ZWINT. /evidence=ECO:0000269\|PubMed:16732327	251..618		87/417 (21%)
		Interaction with SMC1A	251..431		43/207 (21%)
		Interaction with PSMC2 and SMC1A	361..547		46/240 (19%)
		Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex	446..642		41/194 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55244
OrthoDB	1	1.010	-	-		D364574at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980