DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11178 and Avl9

DIOPT Version :9

Sequence 1:	NP_572901.1	Gene:	CG11178 / 32315	FlyBaseID:	FBgn0030499	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_006236626.1	Gene:	Avl9 / 312371	RGDID:	1564615	Length:	681	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	228/620 - (36%)
Similarity:	335/620 - (54%)	Gaps:	85/620 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EPENKP--PILHILVVGFHHKLGCQVEFSHPPLISGSTGRNE--CPSGWKYLPTLALPDGSHNFA 64
            |.:..|  |:|||:|||||||.|||||||:||||.|. |.:.  .|..|||||:||||||:||:.
  Rat     7 ESDGAPCGPVLHIVVVGFHHKKGCQVEFSYPPLIPGD-GHDSHAVPEEWKYLPSLALPDGAHNYQ 70

  Fly    65 EDTVFFNLPSLYEPAESIYGVSCYRQIRVEKLKIRTADLTRSTVQKSVCILARLPIYGYIEVKLA 129
            ||||||:||.......::||:||||||..:.||:|.||:||.|||||||:|::||:||.::.||.
  Rat    71 EDTVFFHLPPRNGNGATVYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQ 135

  Fly   130 LIADAFFDQGDFSGTELLAKAYQQLN-----ACLQDDESRRPLRHFHVGLSLREIVLHWRHKTLM 189
            ||..|:|::.|||...:|.:.|:.:|     |.|:..:       .::|||.|::|||:|||.|:
  Rat   136 LITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQ-------VYLGLSPRDLVLHFRHKVLI 193

  Fly   190 LFKLMLLQRRVVCFGSPVRQMCVLILGMASLVPRLLEKGFQEVACVRTSRPLSP-------MPDF 247
            ||||:||:::|:.:.|||.::...::.:.||.|.::|.|..:.:..|..:.:|.       .|..
  Rat   194 LFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDAGLQEGNPSA 258

  Fly   248 TDSLQREAQAEAEAELEAVASVAAATDEQKLTPESAT---AVEG--------------------- 288
            .|.:...........|..|..:.|....:...|.:..   .|||
  Rat   259 DDFISESTSDNLNTSLGIVTRIVAVNHGEDAVPPTEKPYFQVEGNNNKGQEHSDTGRYLELPPRP 323

  Fly   289 ---------EAEELALVSSAASAGEEQVSGD-------DTSTRSTPNSQSQDSSNGRNSSLTREA 337
                     |..:.:::..|:....||:..|       |:....:|....|..:|.|...|
  Rat   324 SPESSESDWETLDPSVLEDASLKEREQMGSDQTHLFQKDSVPSDSPPITVQPQANTRQVVL---- 384

  Fly   338 SVDTLASNLAALCAVNPDEYRAPVSIFASGNLCLPYLSLPYMDLLSDPMVLSYVIGTSNVLFQQK 402
             :..|.|.|      ..|:|..|::||..|.|||||::|....||||..|..:|.|.:|:||:|:
  Rat   385 -IPGLISGL------EEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQ 442

  Fly   403 RQLADVLVDIEAANLDAHDPELRRQLVLSTEDLRYMDYIMKHVQSPKEDA-------EGSEYWIR 460
            :.|:|.:|::|.|.:..||||||:.|..:|.|||:.||:::||...::|.       ||.:.|||
  Rat   443 KHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIR 507

  Fly   461 EQFQGYILALLRTAVAPDATPKDNDHFNAHFMGAFKRTQCFQEWYDVRPEPEFFEALPAGHPFAG 525
            .||..||.|||...:..|.....:| :...|:.|:|.|..::.| :....|...|..| .|||.|
  Rat   508 AQFAVYIHALLAATLQLDNEKMLSD-YGTTFVAAWKNTHNYRVW-NSNKHPALAEINP-NHPFQG 569

  Fly   526 TLSVADMKLKLAQTMQNSESGRKINQAVNTTSRAV 560
            ..||:||||:.:.::||||.|:||...:.||||.|
  Rat   570 QYSVSDMKLRFSHSVQNSERGKKIGNVMVTTSRNV 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11178	NP_572901.1	Avl9	11..474	CDD:286833	193/523 (37%)
		Afi1	13..>70	CDD:285085	40/58 (69%)
		SPA	<368..417	CDD:285780	22/48 (46%)
Avl9	XP_006236626.1	Avl9	16..521	CDD:286833	193/523 (37%)
		Afi1	16..>76	CDD:285085	41/60 (68%)
		DENN	116..>226	CDD:299760	46/116 (40%)
		SPA	<382..459	CDD:285780	32/87 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353245
Domainoid	1	1.000	327	1.000	Domainoid score	I1148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62425
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1892
OMA	1	1.010	-	-		QHG56043
OrthoDB	1	1.010	-	-		D1184841at2759
OrthoFinder	1	1.000	-	-		FOG0005854
OrthoInspector	1	1.000	-	-		oto98508
orthoMCL	1	0.900	-	-		OOG6_104063
Panther	1	1.100	-	-	LDO	PTHR31017
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910