Protein Alignment CG11178 and AVL9

DIOPT Version :9

• Sequence 1: NP_572901.1
• Gene: CG11178 / 32315
• FlyBaseID: FBgn0030499
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: XP_005249725.1
• Gene: AVL9 / 23080
• HGNCID: 28994
• Length: 652
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 240/655 - (36%)
• Similarity: 354/655 - (54%)
• Gaps: 95/655 - (14%)

  Fly    10 PILHILVVGFHHKLGCQVEFSHPPLISGSTGRNE--CPSGWKYLPTLALPDGSHNFAEDTVFFNL 72
            |:|||:|||||||.|||||||:||||.|. |.:.  .|..|||||.||||||:||:.||||||:|
Human    15 PVLHIVVVGFHHKKGCQVEFSYPPLIPGD-GHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHL 78

  Fly    73 PSLYEPAESIYGVSCYRQIRVEKLKIRTADLTRSTVQKSVCILARLPIYGYIEVKLALIADAFFD 137
            |.......:::|:||||||..:.||:|.||:||.|||||||:|::||:||.::.||.||..|:|:
Human    79 PPRNGNGATVFGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFE 143

  Fly   138 QGDFSGTELLAKAYQQLN-----ACLQDDESRRPLRHFHVGLSLREIVLHWRHKTLMLFKLMLLQ 197
            :.|||...:|.:.|:.:|     |.|:..:       .::|||.|::|||:|||.|:||||:||:
Human   144 EKDFSQISILKELYEHMNSSLGGASLEGSQ-------VYLGLSPRDLVLHFRHKVLILFKLILLE 201

  Fly   198 RRVVCFGSPVRQMCVLILGMASLVPRLLEKGFQEVACVRTSRPLS---------PMPDFTDSLQR 253
            ::|:.:.|||.::...::.:.||.|.::|.|..:.:..|..:.:|         |..|  |.:..
Human   202 KKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDGGLQESNPCAD--DFVSA 264

  Fly   254 EAQAEAEAELEAVASVAAA---------TDE------------------QKLTPES-----ATAV 286
            .....:...|..:..|.|.         |:|                  |.|.|.|     ::..
Human   265 STADVSHTNLGTIRKVMAGNHGEDAAMKTEEPLFQVEDSSKGQEPNDTNQYLKPPSRPSPDSSES 329

  Fly   287 EGEAEELALVSSAASAGEEQVSGDDTSTRSTPNSQSQDSSNGRNSSLTREASVDT----LASNLA 347
            :.|..:.:::........||:..|.|      |...:||....:..:|.:...:|    |...|
Human   330 DWETLDPSVLEDPNLKEREQLGSDQT------NLFPKDSVPSESLPITVQPQANTGQVVLIPGL- 387

  Fly   348 ALCAVNPDEYRAPVSIFASGNLCLPYLSLPYMDLLSDPMVLSYVIGTSNVLFQQKRQLADVLVD- 411
             :..:..|:|..|::||..|.|||||::|....||||..|..:|.|.:|:||:|::.|:|.:|:
Human   388 -ISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEV 451

  Fly   412 ---IEAANLDAHDPELRRQLVLSTEDLRYMDYIMKHVQSPKEDA-------EGSEYWIREQFQGY 466
               :|.|.:..||||||:.|..:|.|||:.||:::||...::|.       ||.:.|||.||..|
Human   452 RLCVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVY 516

  Fly   467 ILALLRTAVAPDATPKDNDHFNAHFMGAFKRTQCFQEWYDVRPEPEFFEALPAGHPFAGTLSVAD 531
            |.|||...:..| ..|....:...|:.|:|.|..::.| :....|...|..| .|||.|..||:|
Human   517 IHALLAATLQLD-NEKILSDYGTTFVTAWKNTHNYRVW-NSNKHPALAEINP-NHPFQGQYSVSD 578

  Fly   532 MKLKLAQTMQNSESGRKINQAVNTTSR-----------AVGGAISQAKGAFSSWWSSITTAPPNA 585
            |||:.:.::||||.|:||...:.||||           :||||.|.||.|.|||.|:.||:...:
Human   579 MKLRFSHSVQNSERGKKIGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTSQS 643

  Fly   586 TNAGP 590
            ....|
Human   644 LTEPP 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11178	NP_572901.1	Avl9	11..474	CDD:286833	193/525 (37%)
		Afi1	13..>70	CDD:285085	40/58 (69%)
		SPA	<368..417	CDD:285780	22/52 (42%)
AVL9	XP_005249725.1	Avl9	16..524	CDD:286833	193/525 (37%)
		Afi1	16..>76	CDD:285085	41/60 (68%)
		DENN	116..>226	CDD:299760	46/116 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159224
Domainoid	1	1.000	324	1.000	Domainoid score	I1211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62425
Inparanoid	1	1.050	388	1.000	Inparanoid score	I2022
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56043
OrthoDB	1	1.010	-	-		D1184841at2759
OrthoFinder	1	1.000	-	-		FOG0005854
OrthoInspector	1	1.000	-	-		oto91427
orthoMCL	1	0.900	-	-		OOG6_104063
Panther	1	1.100	-	-	LDO	PTHR31017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R125
SonicParanoid	1	1.000	-	-		X4244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940