Protein Alignment up and TNNT3

DIOPT Version :10

• Sequence 1: NP_525088.2
• Gene: up / 32314
• FlyBaseID: FBgn0004169
• Length: 397
• Species: Drosophila melanogaster
• Sequence 2: NP_001354775.1
• Gene: TNNT3 / 7140
• HGNCID: 11950
• Length: 269
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 99/285 - (34%)
• Similarity: 147/285 - (51%)
• Gaps: 60/285 - (21%)

  Fly     1 MSD------DEEYTSSEE-------------------EEVVEETREETKP------PQTPAEGEG 34
            |||      :|:|...||                   |:..||..||.||      |:.| |||.
Human     1 MSDEEVEQVEEQYEEEEEAQEEAAEVHEEVHEPEEVQEDTAEEDAEEEKPRPKLTAPKIP-EGEK 64

  Fly    35 -DPEFIKRQDQKRSDLDDQLKEYITEWRKQRSKEEDELKKLKEKQAKRKVTRAEEEQKMAQRKKE 98
             |.:.|:::.|.:..:  :|:..|....:.|.|||:||..|||:..||:..|||:::..|::
Human    65 VDFDDIQKKRQNKDLM--ELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEK--- 124

  Fly    99 EEERRVREAEEKKQREIEEKRMRLEEAEKKRQAMLQAMKDKDKKGPNFT--IAKKDAGVLGLSSA 161
            |.||:.|.||||.:||.|:.:.|.|:..||::|:       ...|.|::  :||.|
Human   125 ERERQNRLAEEKARREEEDAKRRAEDDLKKKKAL-------SSMGANYSSYLAKAD--------- 173

  Fly   162 AMERNKTKEQLEEEKKISLSFRIKPLAIEGFGEAKLREKAQELWELIVKLETEKYDLEERQKRQD 226
             .:|.|.:...|.:||| |:.|.|||.|:..||.|||:||:||||.:.:||.:|::..|:.|||.
Human   174 -QKRGKKQTAREMKKKI-LAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQK 236

  Fly   227 YDLKELKERQKQQLRHKALKKGLDP 251
            ||:..|:.|..|..:|.  ||...|
Human   237 YDITTLRSRIDQAQKHS--KKAGTP 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
up	NP_525088.2	Smc	<39..>249	CDD:440809	78/211 (37%)
		Troponin	156..>233	CDD:460018	32/76 (42%)
TNNT3	NP_001354775.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		21/71 (30%)
		Troponin	73..209	CDD:460018	55/158 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..158		19/49 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..269		6/17 (35%)