DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment up and Tnnt1

DIOPT Version :9

Sequence 1:	NP_001162742.1	Gene:	up / 32314	FlyBaseID:	FBgn0004169	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_599215.2	Gene:	Tnnt1 / 171409	RGDID:	621852	Length:	261	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	97/284 - (34%)
Similarity:	143/284 - (50%)	Gaps:	50/284 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDDEEYTSSEEEEVVEETREETKP--PQTPAEGEGD---------PEFI--KRQDQKRSDLDD- 51
            |||.||....||:...||..||..|  |:..||.|.:         |..|  |..:.:|.|.||
  Rat     1 MSDTEEQEYEEEQAEDEEAVEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGERVDFDDI 65

  Fly    52 ----------QLKEYITEWRKQRSKEEDELKKLKEKQAKRKVTRAEEEQKMAQRKKEEEERRVRE 106
                      :|:..|....:||.|||:||..||::..:|:..|||:::   .|.::|.||:.:.
  Rat    66 HRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQR---FRTEKERERQAKL 127

  Fly   107 AEEKKQREIEEKRMRLEEAEKKRQAMLQAMKDKDKKGPNFTIAKKDAGVLGLSSAAMERNKTKEQ 171
            ||||.::|.||.:.|.|:..||::.:       ...|.:|      .|.|    ...|:.:.|.|
  Rat   128 AEEKMRKEEEEAKKRAEDDAKKKKVL-------SNMGAHF------GGYL----VKAEQKRGKRQ 175

  Fly   172 LEEEKKIS-LSFRIKPLAIEGFGEAKLREKAQELWELIVKLETEKYDLEERQKRQDYDLKELKER 235
            ...|.|:. ||.|.|||.|:..||.:||||||||.|.|.:||:||:||.|:.|:|.|::..|..|
  Rat   176 TGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYEINVLYNR 240

  Fly   236 QKQQLRH-KALKKGLDPEALTGKY 258
                :.| :..:||.....:.|::
  Rat   241 ----ISHAQKFRKGAGKGRVGGRW 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
up	NP_001162742.1	Troponin	156..>233	CDD:395788	35/77 (45%)
Tnnt1	NP_599215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61		20/59 (34%)
		Troponin	68..204	CDD:395788	49/155 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..152		18/46 (39%)
		Troponin	179..>237	CDD:395788	31/57 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350892
Domainoid	1	1.000	50	1.000	Domainoid score	I11374
eggNOG	1	0.900	-	-		E1_KOG3634
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4652
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45212
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11521
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.850