DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXD1 and Scr

DIOPT Version :9

Sequence 1:	NP_078777.1	Gene:	HOXD1 / 3231	HGNCID:	5132	Length:	328	Species:	Homo sapiens
Sequence 2:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	209	Identity:	67/209 - (32%)
Similarity:	90/209 - (43%)	Gaps:	57/209 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    93 PGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAF 157
            |.:...:.|...:.|.||        |.|..||...|.:.:::.|.| |||     .|.|: ...
  Fly   221 PSSVVESVARSLNKGVLG--------GSLAAAAAAAGLNNNHSGSGV-SGG-----PGNVN-VPM 270

Human   158 GEPGPFPACLKASADGHPGAFQTASPA----PGTYPKSVSPASGLPAAFSTFEWMK--------V 210
            ..||...:..::.:....|:.|.:...    |..||                 |||        |
  Fly   271 HSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYP-----------------WMKRVHLGTSTV 318

Human   211 KRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKI 275
            ..|...|.:             ||:::..|..|||||||||:||||.||||||:.|.|.:.|:||
  Fly   319 NANGETKRQ-------------RTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKI 370

Human   276 WFQNRRMKQKKRER 289
            ||||||||.||..:
  Fly   371 WFQNRRMKWKKEHK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXD1	NP_078777.1	Antp-type hexapeptide	204..209		1/4 (25%)
		Homeobox	233..285	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810