DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neto and MFRP

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_113621.1	Gene:	MFRP / 83552	HGNCID:	18121	Length:	579	Species:	Homo sapiens

Alignment Length:	426	Identity:	94/426 - (22%)
Similarity:	153/426 - (35%)	Gaps:	91/426 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SLLMLLIVGQAVYASAGSEIIANRSASAGESLIMLSNFTVATPPPAPRFTSPFREQDVAEGEELA 102
            |.|:||::|..|                   .|:|:....|  ||:....||           |.
Human    74 SSLLLLLLGLLV-------------------AIILAQLQAA--PPSGASHSP-----------LP 106

  Fly   103 GGGQVDWLDEQHPLTISRPPRAGRSERQAEE----DQVDRCRLFVEGDPTKNELYSPEYPNLYPK 163
            .||........   ||:....||..:.|.|.    .....|...:.|  .:....||.||:.||.
Human   107 AGGLTTTTTTP---TITTSQAAGTPKGQQESGVSPSPQSTCGGLLSG--PRGFFSSPNYPDPYPP 166

  Fly   164 NINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSK 228
            |.:|...|.......|:|.. .:.:||:...|.||.||:.....|  .|: :.||...||.:.:.
Human   167 NTHCVWHIQVATDHAIQLKI-EALSIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTN 227

  Fly   229 ERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTD------LNCTIDKGGFEGFINSTD----- 282
            ..:|.:.|.||.::|..||.|.|:.:...|.:.:.|      |.|.:.....:||.|..|
Human   228 ASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDET 292

  Fly   283 ---------------------VPAEIWEQVNRNKIALDCIWRIQVKENWKIFLKFLDFKLSKPND 326
                                 .|:.:.:..::    |.|.|.|.|.....|.|:|.:|.|...::
Human   293 NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQ----LLCTWHISVPAGHSIELQFHNFSLEAQDE 353

  Fly   327 CQTNFLDIFPEQTVMPLR-VKNFCGS-AGESITAESNILHLRFYADQTAINSTFGILFTAFRERG 389
            |:.::::::...:..... :..|||: ....:.:..:.|.:.|..|....:..|...:.||....
Human   354 CKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418

  Fly   390 AACTEDEYDCEDATCISKDLKCN--------NLDNC 417
            ..|...|..|:...|......|:        :.|||
Human   419 NPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNC 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	32/100 (32%)
		CUB	<298..384	CDD:238001	18/87 (21%)
		LDLa	392..426	CDD:238060	8/34 (24%)
MFRP	NP_113621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..143		11/56 (20%)
		CUB	144..252	CDD:238001	35/113 (31%)
		LDLa	260..294	CDD:238060	7/33 (21%)
		CUB	301..411	CDD:238001	19/113 (17%)
		LDLa	421..454	CDD:238060	6/32 (19%)
		Fz	466..569	CDD:279700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910