DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neto and Neto2

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	XP_030099678.1	Gene:	Neto2 / 74513	MGIID:	1921763	Length:	560	Species:	Mus musculus

Alignment Length:	495	Identity:	137/495 - (27%)
Similarity:	221/495 - (44%)	Gaps:	86/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 RCRLFVEGDPTKN--ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFL 200
            :|.::|.   |.|  ...||.||:.||.|..|..::.|...|.|.|.|...:.||....|:||.|
Mouse    79 QCGIWVR---TSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHL 140

  Fly   201 EIRDGQYGFSTLIGKFCGTDFPPEITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDL 265
            |||||.:|||.||.::||...|..|.|..|::|:.|.|||.:|..||.|.|.::      |..|.
Mouse   141 EIRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFI------PDPDF 199

  Fly   266 -----------NCTIDKGGFEGFINSTDVPAEIWEQVNRNK--IALDCIWRIQVKENWKIFLKFL 317
                       :|..:..|.:|.:.|:.|     ||..:.|  .|:||||.|:.....||:|:||
Mouse   200 TYLGGILNPIPDCQFELSGADGIVRSSQV-----EQEEKTKPGQAVDCIWTIKATPKAKIYLRFL 259

  Fly   318 DFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGSAGESITAESNILHLRFYADQTAINSTFGILF 382
            |:::...|:|:.||:.::...:.:......||.:....:..::.:..:|.:||:.:..|.|.:||
Mouse   260 DYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLF 324

  Fly   383 TAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC-TSEAAGQSE-----HVVIIV 441
            |:|.|  ..||...:.|....||:..|.||.:.||.:.|||..| ..:.||..|     |..||.
Mouse   325 TSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIG 387

  Fly   442 IVFGLILGGMVITFIVNC---IRKI-------------------------IRDQKIIREHIRESK 478
            |..|::|..::|:.:|..   .:|:                         :|:::|..:....|:
Mouse   388 ITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSE 452

  Fly   479 ESKLDEMGRNSKGRSR--------ENISRQKHSQTSLQILDDVSNRYYREAVPLSSQSSKADFKE 535
            |....:..|.|...||        ...|..|.|:|:|..::......:.:..|:.:.:|  .||:
Mouse   453 ELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNS--TFKK 515

  Fly   536 KEHSILRRH-------ADMTQTSL-CGV---GEDDGESSS 564
            ..::..:.|       .|.....: |.:   |.||...:|
Mouse   516 SSYTFKQAHECPEQALEDRVMEEIPCEIYVRGRDDSAQAS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	44/100 (44%)
		CUB	<298..384	CDD:238001	24/85 (28%)
		LDLa	392..426	CDD:238060	13/33 (39%)
Neto2	XP_030099678.1	CUB	80..193	CDD:238001	49/115 (43%)
		CUB	<240..326	CDD:238001	24/85 (28%)
		LDLa	332..366	CDD:238060	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002629
OrthoInspector	1	1.000	-	-		otm44079
orthoMCL	1	0.900	-	-		OOG6_106092
Panther	1	1.100	-	-	LDO	PTHR24251
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3576
SonicParanoid	1	1.000	-	-		X1989
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.940