DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neto and CG42613

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001247185.1	Gene:	CG42613 / 42269	FlyBaseID:	FBgn0261262	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	110/477 - (23%)
Similarity:	180/477 - (37%)	Gaps:	109/477 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 FVEGDPTKNELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRNSFNIEAKE------------G 194
            :|.....:.||.||.||:.||.:.||:.:..|...:.:.:.| :.|.|:|..            .
  Fly   711 YVSSSKKRGELNSPRYPSNYPSDTNCSYLFLAEADEQVTIVF-DHFKIKADNNANATAGAYGSGA 774

  Fly   195 CKFDFLEI----RDGQYGFSTLIGKFCGTDFPPEITSKERYLWLH--FHSDETIEYTGFSAVYEY 253
            |..|:||:    ||..   ..|:|::||...|..:.|....:.|.  .|:|:....:||.|.|.:
  Fly   775 CFEDWLEMYVVYRDNN---DRLLGRYCGQTAPGPVESPRGAVGLRITLHTDQESVASGFKARYFF 836

  Fly   254 LDRSRDAPSTDLNCTIDKGG-----FEGFINSTDVPAEIWEQVNRNKIALDCIWRIQVKENWKIF 313
            .....||.        |.||     ..|.|.|.:.||. ::...|...:..|.|.::.:..:|:.
  Fly   837 ESAKSDAG--------DCGGNFSNQDSGLITSPNWPAG-YKAPGRGMASNACNWVMKARPGYKLS 892

  Fly   314 LKFLDFKLSK-------PNDCQTNFLDIFPEQTVMPLRVKNFCGSAGE----SITAESNILHLRF 367
            :.|..|.|..       |......::::..:|..:.|     ||....    ..|:......:.|
  Fly   893 IHFEQFGLEGDPANRGCPAAVLRLWMNVDSDQPPLEL-----CGEKPPVEQWHYTSTGQTARISF 952

  Fly   368 -YADQTAINSTFGILFTAFRERGAA-------CTED-EYDCEDATCISKDLKCNNLDNC--KFRW 421
             .:|:|.....|.|::|..::.|..       |... .:.|....|||..|:|:.:.||  ....
  Fly   953 TTSDKTVGAQGFRIVWTEIQDSGPGPPSVGLHCESTYHFQCGAGYCISDKLRCDGVKNCGPGDDT 1017

  Fly   422 DEEGCTSEAAGQSEHVVIIVIVFGLILGGMVITFIVNCIRKIIRDQKIIREHIRESKESKLDEMG 486
            ||..||:|||.:...|:||:.:  |::..::....:.|             |.|.|:.:.:.::|
  Fly  1018 DELHCTTEAAEEDYDVLIIITL--LVVSSLICLLCILC-------------HSRRSRRNHVRQLG 1067

  Fly   487 RNSKGRSRENISRQKH--SQTSLQILDDVSNRYYREAVPLSSQSSKADFKEKEHSI-----LRRH 544
                      :.|..|  ||||.......|.|:.        ||..|......|.|     :...
  Fly  1068 ----------LHRNAHYDSQTSATAGLSSSRRHL--------QSGGASIAGSLHGINSGNLIIPP 1114

  Fly   545 ADMTQTS------LCGVGEDDG 560
            |.:..||      :|..|.|.|
  Fly  1115 APLPPTSVPPPPHICIAGVDMG 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	33/118 (28%)
		CUB	<298..384	CDD:238001	17/97 (18%)
		LDLa	392..426	CDD:238060	11/36 (31%)
CG42613	NP_001247185.1	CUB	277..404	CDD:238001
		CUB	421..541	CDD:238001
		CUB	564..691	CDD:238001
		CUB	707..836	CDD:238001	35/128 (27%)
		CUB	846..969	CDD:238001	25/128 (20%)
		LDLa	987..1022	CDD:238060	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910