DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neto and Neto2

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001100887.2	Gene:	Neto2 / 307757	RGDID:	1305310	Length:	525	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	136/496 - (27%)
Similarity:	223/496 - (44%)	Gaps:	88/496 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 RCRLFVEGDPTKN--ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFL 200
            :|.::|.   |.|  ...||.||:.||.|..|..::.|...|.|.|.|...:.||....|:||.|
  Rat    44 QCGIWVR---TSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHL 105

  Fly   201 EIRDGQYGFSTLIGKFCGTDFPPEITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDL 265
            |:|||.:|||.||.::||...|..|.|..|::|:.|.|||.:|..||.|.|.::      |..|.
  Rat   106 EVRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFI------PDPDF 164

  Fly   266 -----------NCTIDKGGFEGFINSTDVPAEIWEQVNRNK--IALDCIWRIQVKENWKIFLKFL 317
                       :|..:..|.:|.:.|:.|     ||..:.|  .|:||||.|:.....||:|:||
  Rat   165 TYLGGILNPIPDCQFELSGADGIVRSSQV-----EQEEKTKPGQAVDCIWTIKATPKAKIYLRFL 224

  Fly   318 DFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGSAGESITAESNILHLRFYADQTAINSTFGILF 382
            |:::...|:|:.||:.::...:.:......||.:....:..::.:..:|.:||:.:..|.|.:||
  Rat   225 DYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLF 289

  Fly   383 TAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC-TSEAAGQSE-----HVVIIV 441
            |:|.|  ..||...:.|....||:..|.||.:.||.:.|||..| ..:.||..|     |..||.
  Rat   290 TSFVE--PPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIG 352

  Fly   442 IVFGLILGGMVITFIVNC---IRKI-------------------------IRDQKIIREHIRESK 478
            :..|::|..::|:.:|..   .:|:                         :|:::|..:....|:
  Rat   353 VTSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSE 417

  Fly   479 ESKLDEMGRNSKGRSR--------ENISRQKHSQTSLQILDDVSNRYYREAVPLSSQSSKADFKE 535
            |....:..|.|...||        ...|..|.|:|:|..::......:.:..|:.:.:|  .||:
  Rat   418 ELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNS--TFKK 480

  Fly   536 KEHSILRRHADMTQTSL---------CGV---GEDDGESSS 564
            ..::..:.| |..:.:|         |.:   |.||...:|
  Rat   481 SSYTFKQTH-DCPEQALEDRVMEEIPCEIYVRGRDDSAQAS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	43/100 (43%)
		CUB	<298..384	CDD:238001	24/85 (28%)
		LDLa	392..426	CDD:238060	13/33 (39%)
Neto2	NP_001100887.2	CUB	45..158	CDD:238001	48/115 (42%)
		CUB	<205..291	CDD:238001	24/85 (28%)
		LDLa	297..331	CDD:238060	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6911
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002629
OrthoInspector	1	1.000	-	-		otm46172
orthoMCL	1	0.900	-	-		OOG6_106092
Panther	1	1.100	-	-	LDO	PTHR24251
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1989
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910