DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neto and neto-1

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_491159.3	Gene:	neto-1 / 186950	WormBaseID:	WBGene00019360	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	127/374 - (33%)
Similarity:	195/374 - (52%)	Gaps:	52/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HPLTISRPPRAGRSERQAEEDQVDRCRLFVEGDPTKN-ELY-SPEYPNLYPKNINCTRVI-TAPK 175
            |..|.|.||            |.|:| |.::|...:| .:: ||.:|:.||.||:|.||| :.|:
Worm    13 HSTTGSPPP------------QFDQC-LSIKGIGLQNFNIFTSPNFPDRYPPNIDCVRVIHSRPQ 64

  Fly   176 GQIIRLDFRNSFNIE-------AKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPP-EITSKERYL 232
            ..:: :.|.:.|:||       |.|.|..||:|.|||:||||.||.:|||...|. ||.:...:|
Worm    65 HDVV-VKFHHVFHIESTYDKIDAGEECPNDFIEFRDGRYGFSPLIARFCGDRMPKREIRAVSGFL 128

  Fly   233 WLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTID-KGGFEGFINSTDVPAEIWEQVNRNKI 296
            |:.|.||..:||.||||.|..:. |:.....:..|.:: ..|.:|||.:.|:.:.:    .||..
Worm   129 WIRFRSDSMLEYQGFSAEYAIVP-SKTGRFNNHECLLEYLNGLDGFIRTKDLISNL----PRNAS 188

  Fly   297 -ALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTV-MPLRVKNFCGSAGESITAE 359
             .|||:||:.|..|::|.....:|.|:.||.|..||::::...|. .|||  .|||.....:.:.
Worm   189 GTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKPLR--RFCGLTANDVFSP 251

  Fly   360 SNILHLRFY-ADQTAINST-FGILFTAFRERGAACTEDE-YDCEDATCISKDLKCNNLDNCKFRW 421
            ||.:.:||| :|..::|:| ...||::: .|...||::. :.|.|..|:.|.|.||...||.:..
Worm   252 SNEMFVRFYLSDVRSLNTTSISALFSSY-TRLKNCTQEGLFACGDENCVPKSLACNGRPNCPYGR 315

  Fly   422 DEEGCTSE--------AAGQSEHVVIIVIVFGLILGGMVITFIV---NC 459
            ||..|:..        |:|.:..|.||:||  ||:..::..:.:   ||
Worm   316 DERVCSVGQDTIFSFLASGFAPLVSIILIV--LIVVSLICFYTIRKNNC 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	48/110 (44%)
		CUB	<298..384	CDD:238001	32/88 (36%)
		LDLa	392..426	CDD:238060	13/34 (38%)
neto-1	NP_491159.3	CUB	39..147	CDD:238001	48/108 (44%)
		CUB	182..278	CDD:238001	34/101 (34%)
		LDLa	291..320	CDD:238060	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I4778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002629
OrthoInspector	1	1.000	-	-		oto17791
orthoMCL	1	0.900	-	-		OOG6_106092
Panther	1	1.100	-	-	LDO	PTHR24251
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3576
SonicParanoid	1	1.000	-	-		X1989
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.940