DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neto and neto1l

DIOPT Version :9

Sequence 1:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	XP_021325973.1	Gene:	neto1l / 100331363	ZFINID:	ZDB-GENE-091207-1	Length:	548	Species:	Danio rerio

Alignment Length:	534	Identity:	148/534 - (27%)
Similarity:	238/534 - (44%)	Gaps:	99/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 AGRSERQAEEDQ-----VDRCRLFVEGDPTKNELYSPEYPNLYPKNINCTRVITAPKGQIIRLDF 183
            :|.::::|.::.     ..:|..:|: :|......||.|||.||....|..:|.||..|.|.|.|
Zfish    20 SGATKKEAVKNNSGVQPAGQCGTWVK-EPEGGLFTSPNYPNKYPPERECIYIIEAPPRQCIDLFF 83

  Fly   184 RNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKERYLWLHFHSDETIEYTGFS 248
            ...::||....||||.:|:|||.:|||.:||::||...||.|.|..||||:.|.:|..:|..|||
Zfish    84 DEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRYCGQQNPPYIRSSGRYLWIKFVADGELEAMGFS 148

  Fly   249 AVYEYLDRSRDAPSTDLN-------CTIDKGGFEGFINSTDVPAEIWEQVNRNKIAL-----DCI 301
            |.|.:   :.|....|:.       |..:.||.||.|.|        :|:.::..||     ||.
Zfish   149 ASYNF---TSDPDFKDIGVPKPLPFCEFEMGGPEGIIES--------QQITKDGRALQTEAVDCK 202

  Fly   302 WRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFP-EQTVMPLRVKNFCGSAGESITAESNILHL 365
            |.|:.....||:|:|||:::...|:|:.|::.::. ..:|..||.| ||.:....:...|.:..:
Zfish   203 WYIRAPPRSKIYLRFLDYEMQNSNECKRNYVAVYDGSSSVEDLRNK-FCSTVANDVMLVSALGVI 266

  Fly   366 RFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGCTSEA 430
            |.:||:.:..|.|.||||.|:|  ..|..|.:.|....||:..|.||.:.||.:.|||..|..:.
Zfish   267 RMWADEGSRKSRFRILFTTFQE--PPCEADTFFCHSNMCINNTLVCNGIQNCVYPWDENHCKEKR 329

  Fly   431 AG------QSEHVVIIVIVFGLILGGMVITFIVN--------CIRKIIRDQKIIREHIRE----- 476
            ..      .:.:..||.:...::|..::::.||.        .:|:...|..:.:|..:|
Zfish   330 KANILDSLNNTNGTIIGVTCCIVLILLIVSVIVQIKQPRKKYILRREDFDPTMFQEVFQEPPHYE 394

  Fly   477 --------SKESKLDEMG---------RNSKGR-------SRENISRQKHSQTSLQ--------I 509
                    :..:.|.|:.         |.:..|       ....||..|.|:|:|.        |
Zfish   395 LCTLRSAAATSADLAELAEDFESYHKLRRASSRCIHEHHCGSSQISSNKGSRTNLSARDAAAAAI 459

  Fly   510 LDDVSNRYYREAVPLSSQSSKADFKEKEHSILRRHA-DMTQTSLCGVGEDDGESSSTTTATHEMM 573
            |.|:..:..|   ||..|:::.:.      ::.||. ....|..|   |.|.|.....|.:|.:.
Zfish   460 LTDLPPQPMR---PLPPQTNRRNI------LVMRHTYSQDATDAC---ELDDELEEVPTTSHRLS 512

  Fly   574 --TKAAMSAVPSNA 585
              .||....:.::|
Zfish   513 RHEKAVQRLLENSA 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neto	NP_001285211.1	CUB	151..252	CDD:238001	47/100 (47%)
		CUB	<298..384	CDD:238001	29/91 (32%)
		LDLa	392..426	CDD:238060	13/33 (39%)
neto1l	XP_021325973.1	CUB	40..153	CDD:238001	51/113 (45%)
		CUB	<199..285	CDD:238001	28/86 (33%)
		LDLa	291..325	CDD:238060	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6730
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002629
OrthoInspector	1	1.000	-	-		otm25574
orthoMCL	1	0.900	-	-		OOG6_106092
Panther	1	1.100	-	-	O	PTHR24251
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1989
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910