Protein Alignment Set2 and SETDB1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Alignment Length: 1572
• Identity: 299/1572 - (19%)
• Similarity: 489/1572 - (31%)
• Gaps: 528/1572 - (33%)

  Fly   219 VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLK--LGGRLESSDSGNSPSSS 281
            :|.|...|    :.|.:..|.:..||.    |....:|.:|::.|:  :...||..|........
Human     4 LPGCIGLD----AATATVESEEIAELQ----QAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 60

  Fly   282 SPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEV 346
            ..|:|...:|.|:.:....:...:.||.|   .|.:|..:..:.::..:......|.|..||.|:
Human    61 LAELETWVIQKESEVAHVDQLFDDASRAV---TNCESLVKDFYSKLGLQYRDSSSEDESSRPTEI 122

  Fly   347 EPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPA 411
                 |:|            |:||.|.:.::         |.|..:...:|..::.|....::.|
Human   123 -----IEI------------PDEDDDVLSID---------SGDAGSRTPKDQKLREAMAALRKSA 161

  Fly   412 ADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAES----SKQILEAEESQDQEEQHIL-IDL 471
            .|........:::|:  |....:| ||.:...|::.:.    |.:||..:.::...:..:: |..
Human   162 QDVQKFMDAVNKKSS--SQDLHKG-TLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQT 223

  Fly   472 I--------------EDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK 522
            :              :..||.:.:.....|..:.:.|...||.:.:         |..|.::...
Human   224 VGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYK---------DGNQVWLYAG 279

  Fly   523 VFSESDNIAASLNKDI-FEPKVETKATCGEVVP--RPEMVT----EDV----YITEGIAA----- 571
            :.:|:.|:...|...| |:....:..|..|:.|  ||...|    ||:    :|.|.:.|
Human   280 IVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRP 344

  Fly   572 -TLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDES-------DPKQTEVELPES---KPAVNIP 625
             .|.||..:.|...|........:||       |.|       |.|:.|.....|   :|..::.
Human   345 MVLLKSGQLIKTEWEGTWWKSRVEEV-------DGSLVRILFLDDKRCEWIYRGSTRLEPMFSMK 402

  Fly   626 KSERILSAEVETTSSPL-VPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPP 689
            .|.   ::.:|.....| ..|....:.| .|||:    ..|::.:....:..|:  |..:..:||
Human   403 TSS---ASALEKKQGQLRTRPNMGAVRS-KGPVV----QYTQDLTGTGTQFKPV--EPPQPTAPP 457

  Fly   690 AAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQ---------KGQKQTPLPEMKEP--- 742
            |.|...|...|.:..    |.||.:.|:|:.........         .|......|.:.|.
Human   458 APPFPPAPPLSPQAG----DSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSG 518

  Fly   743 ---------EKPVAETVSKKEKAMENPARSS-PAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSK 797
                     ..|:..|.|.       ||.|: ||.....|..|.:|:...:.:.....||.....
Human   519 GKPGINQTYRSPLGSTASA-------PAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLP 576

  Fly   798 KSC-----AAVTPAKQKE-SGK--------------SAKEAILKK-------------------- 822
            ..|     :.|.|.:.:: .||              :|:..:.:|
Human   577 HVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQE 641

  Fly   823 ------ETEKEKSSAKLDSSSPNTL-DKK---------------GKDTAQWSPQLQTLPKSSTKP 865
                  ||..:....::....|..| |:|               ||:..    .|..:.:..|.|
Human   642 IERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDV----PLSCVNEIDTTP 702

  Fly   866 PQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQ 930
            |.:.|.|              ::....||:..|:.|..|          |.||......|
Human   703 PPQVAYS--------------KERIPGKGVFINTGPEFL----------VGCDCKDGCRD----- 738

  Fly   931 LRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNT-----VYEDSPNLERN 990
                   |.|.......::|       ||....||....||....|...     |||.:...:.:
Human   739 -------KSKCACHQLTIQA-------TACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCD 789

  Fly   991 SSPSSDSAQANTSAGKLKPSKVKKK---IN-----PRRSTIC----------------------- 1024
            .:..::....:....:|:..|.:.|   |.     .:.|.:|
Human   790 PNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEY 854

  Fly  1025 -------EAAKDLRSSSSSSTPTREVAASSPVSTSSDSS-----SKRNGSKRTTSDLDGGSKLDQ 1077
                   |:.::.:....|..|           .|||||     .:.:|:..|....:  |..|.
Human   855 FANLDHIESVENFKEGYESDAP-----------CSSDSSGVDLKDQEDGNSGTEDPEE--SNDDS 906

  Fly  1078 RRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDS- 1141
            .....|:|....|                :|....:.|..||    ||:||  ..||...|.||
Human   907 SDDNFCKDEDFST----------------SSVWRSYATRRQT----RGQKE--NGLSETTSKDSH 949

  Fly  1142 --------------------SSSASQGAPKKKALK--SAEILS----------AALLETESSEST 1174
                                :..:|:..||.|...  |...:|          ::....|..|..
Human   950 PPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGR 1014

  Fly  1175 SSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRK------EGQDEVKREAD 1233
            :.||:|         |.|.|:..|   ..|:|..::.:..|.|.|.|.      |..........
Human  1015 AGGSRM---------EAEKASTSG---LGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPS 1067

  Fly  1234 PEEDEFAQRVANMETPATTPTPSPT------------QSNPED----SASTTTVLKELETGGGVR 1282
            |.:.|..:|           .||.|            ||||:|    |:||     |.|...|..
Human  1068 PVKPEGLRR-----------PPSKTSMHQSRRLMASAQSNPDDVLTLSSST-----ESEGESGTS 1116

  Fly  1283 RSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYR 1347
            |.         |.|.|....|      :..|:       |:.|:.   .||| :.|:..|.....
Human  1117 RK---------PTAGQTSATA------VDSDD-------IQTISS---GSEG-DDFEDKKNMTGP 1155

  Fly  1348 CARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWP 1412
            ..|||:.::..    .|...........|.....:::.   |..|:..|
Human  1156 MKRQVAVKSTR----GFALKSTHGIAIKSTNMASVDKG---ESAPVRKN---------------- 1197

  Fly  1413 CRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVID 1477
            .|.|...::.|                                                  .:||
Human  1198 TRQFYDGEESC--------------------------------------------------YIID 1212

  Fly  1478 ATSKGNISRYINHSCDPNAETQKWTVN-GELR---IGFFSVKPIQPGEEITFDYQYLRYGRDAQR 1538
            |..:||:.||:||||.||...|...|: .:||   :.||:.|.|:.|.|:|:||.|.....:.:.
Human  1213 AKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKE 1277

  Fly  1539 --CYCEAANCRG 1548
              |.|.|..|||
Human  1278 LLCCCGAIECRG 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	30/190 (16%)
		AWS	1358..1410	CDD:197795	5/51 (10%)
		SET_SETD2	1410..1551	CDD:380949	36/145 (25%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147		13/64 (20%)
		DUF5604	193..250	CDD:408109	6/56 (11%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	21/89 (24%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	13/59 (22%)
		MBD	598..673	CDD:128673	9/74 (12%)
		SET_SETDB1	675..>876	CDD:380915	38/247 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		81/380 (21%)
		SET	<1203..1292	CDD:394802	34/137 (25%)