DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and KMT2B

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	2442	Identity:	476/2442 - (19%)
Similarity:	699/2442 - (28%)	Gaps:	907/2442 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGPPSNPSPVASRGRGRGRPPKV----ALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSEC 64
            :|..|.|.|.::|||..|||...    .....||....:..:|:..   ...|.|...:.|:...
Human     5 AGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRG---GGATGPGGAEPGEDTA 66

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNP--------------------------STG 103
                        :..||...|...:::   |:.:.|                          |.|
Human    67 ------------LLRLLGLRRGLRRLR---RLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDG 116

  Fly   104 HS--------QSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPPP-----PPTA 155
            .|        .|....|.:|:.:|..|....:......:        |::.|.|||     .||.
Human   117 ESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRK--------HKTTPLPPPRLADVAPTP 173

  Fly   156 LEIFAKPRP-----------TQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRK-RGRP----- 203
            .:..|:.|.           |:.|..||....|.:          ....|.|||: ||||
Human   174 PKTPARKRGEEGTERMVQALTELLRRAQAPQAPRS----------RACEPSTPRRSRGRPPGRPA 228

  Fly   204 ----RKSQ---LADAAII------PTVIVP--------SCSDSDTNSTSTTTSNMSSDSGELPG- 246
                ||.|   :|:||:.      |..:||        .|.:.......|......|..|...|
Human   229 GPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGR 293

  Fly   247 ---------FPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERP-- 300
                     |.|:......:|.:.:|.||  |||.........|..:|  |..:..:.....|
Human   294 GRGRGGGLPFVIKFVSRAKKVKMGQLSLG--LESGQGQGQHEESWQDV--PQRRVGSGQGGSPCW 354

  Fly   301 -KQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPT 364
             ||||.|.   |.||...        |.|.:..:|||::|.....|:.|.    .:.|.||..|.
Human   355 KKQEQKLD---DEEEEKK--------EEEEKDKEGEEKEERAVAEEMMPA----AEKEEAKLPPP 404

  Fly   365 P-----------------DPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAA 412
            |                 .|...|.......:|.||........|:||     |..:||...||
Human   405 PLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEE-----QEESPPPVVPA- 463

  Fly   413 DSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLS 477
             :||    |.|...||:.|.|    .|...|....|.:.                     ..|.:
Human   464 -TCS----RKRGRPPLTPSQR----AEREAARAGPEGTS---------------------PPTPT 498

  Fly   478 ESEVTSSV---SPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIF 539
            .|..|...   |||:               ..::...|.:.::|::..|.:.|..:..:..:.:.
Human   499 PSTATGGPPEDSPTV---------------APKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMD 548

  Fly   540 EPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKD 604
            |..           |:|..|              |.|.|:..|.|             ..||:..
Human   549 EDP-----------PKPPKV--------------EVSPVLRPPIT-------------TSPPVPQ 575

  Fly   605 ESD--PKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEE 667
            |..  |.......|.|.| |.:|:..|.:..|                     |....|||:.|
Human   576 EPAPVPSPPRAPTPPSTP-VPLPEKRRSILRE---------------------PTFRWTSLTRE- 617

  Fly   668 KSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFL-----------LEDYESNQEQVAEDE 721
                 :...|.........|||.||    :.||..|..|           |:.|||
Human   618 -----LPPPPPAPPPPPAPSPPPAP----ATSSRRPLLLRAPQFTPSEAHLKIYES--------- 664

  Fly   722 MMKCNNQKGQKQTP----LPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVV 782
                      ..||    .||..|||.|              ||..|||         |.|.:.|
Human   665 ----------VLTPPPLGAPEAPEPEPP--------------PADDSPA---------EPEPRAV 696

  Fly   783 KSTKG-TVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGK 846
            ..|.. ::|      :.:....||.|.:.|...|...                |:.|.|
Human   697 GRTNHLSLP------RFAPVVTTPVKAEVSPHGAPAL----------------SNGPQT------ 733

  Fly   847 DTAQ-----WSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKA 906
             .||     .:.|.|.||: :..|||   |.:       ||.|..:|           .|.:.||
Human   734 -QAQLLQPLQALQTQLLPQ-ALPPPQ---PQL-------QPPPSPQQ-----------MPPLEKA 775

  Fly   907 KEKAVSGF----VECDAMFKAMDLANAQL-RLDEKNKKKLKKVPTKVEAPPKVEPPTAV-PVPGQ 965
            :...|...    || :.||..:..|..|| ::|::.::       ||.|...:.|...: .|.|.
Human   776 RIAGVGSLPLSGVE-EKMFSLLKRAKVQLFKIDQQQQQ-------KVAASMPLSPGGQMEEVAGA 832

  Fly   966 KKSLSGKTSLRRNTVYED---SPNLERNSSPSS------------DSAQANTSAGKLKPSKVKK- 1014
            .|.:|.:..:|.    ||   ....||.|.|.|            .:|.|...|..:.|..|.:
Human   833 VKQISDRGPVRS----EDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRL 893

  Fly  1015 KINPRRSTICEAAKDLRSSS-SSSTPTR----EVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSK 1074
            ...|.|.....|.:|..|:| :.|.|:|    :|.|:.|...|..:.|             ||:.
Human   894 SALPLRDRQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGS-------------GGTL 945

  Fly  1075 LDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSL 1139
            .          ..|..::|        |.|.|...       :...|..||....::..|..|.|
Human   946 A----------HTPRRSLP--------SHHGKKMR-------MARCGHCRGCLRVQDCGSCVNCL 985

  Fly  1140 DSSSSASQGAPKKK----ALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELE-------- 1192
            |....   |.|..|    ..:..:.:.|..:|..:.:..:....:..||...|||..
Human   986 DKPKF---GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRR 1047

  Fly  1193 ---AANPFGDIAKF--IEDGVNLLKRDKV--------------DEDQRKEGQDEVKREADPEEDE 1238
               |..|..::...  .|:..:||:|...              |.|..:.|.....|...|.|:|
Human  1048 GAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSEPGGPPAPRRRTPRENE 1112

  Fly  1239 FAQRVANMETPATTPTPSP-TQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGV 1302
            .             |.|.| .||.|.  ..|...:.:|:..   ||..:....| ||.||...|.
Human  1113 L-------------PLPEPEEQSRPR--KPTLQPVLQLKAR---RRLDKDALAP-GPFASFPNGW 1158

  Fly  1303 ASVALAP-----ISMD-EQLAELANIEAINEQFLRSEGLNTFQ----------LLKENFYRCARQ 1351
            .....:|     :.:| ::..:|.|:..:.       ||:...          ||      ||.:
Human  1159 TGKQKSPDGVHRVRVDFKEDCDLENVWLMG-------GLSVLTSVPGGPPMVCLL------CASK 1210

  Fly  1352 VSQENAEMQ--CD-----CFLTGDEEAQGHLS----------------CGAGCINRMLMIEC--- 1390
            ...|....|  ||     |.    |||:..|.                ||........::||
Human  1211 GLHELVFCQVCCDPFHPFCL----EEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERC 1271

  Fly  1391 ----GPLC---SNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGE-FIMEYVGEVIDS 1447
                .|.|   |...|.|.||  :|  |.|... ...|.||.|      ||: :.:|:.|   |.
Human  1272 RHAYHPACLGPSYPTRATRKR--RH--WICSAC-VRCKSCGAT------PGKNWDVEWSG---DY 1322

  Fly  1448 EEFERRQHLYSK------------DRN-----------RHYYFMALRGEAVIDATSKGNISRYIN 1489
            ....|...||.|            |.:           .|:......|.:..|......:...:.
Human  1323 SLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVL 1387

  Fly  1490 HSCDP--NAETQKW------TVNGELR---IGFFSVKPIQPGEEITFDYQYLRYGRDAQR----- 1538
            ::|.|  .|...:|      .:.|.||   .|..|.|.:.|....|      :.|.|.::
Human  1388 YTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCT------QCGPDGKQLHPGP 1446

  Fly  1539 CYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQ-PRKSAKAKAKSKLKAKL 1602
            |..:|.:.|        .::|......|..:..:.  .|....|||: |.:.|..:.|..|...|
Human  1447 CGLQAVSQR--------FEDGHYKSVHSFMEDMVG--ILMRHSEEGETPDRRAGGQMKGLLLKLL 1501

  Fly  1603 PLATG--------RKRKEQTKPK------------DREYKAGRWLKPSATGSSSSAEKPPKKPKV 1647
            ..|.|        ..|:....|.            |..|...|..:|....|.    :||..|..
Human  1502 ESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQEPETPESG----QPPGDPSA 1562

  Fly  1648 NKFQ-------AMLEDP--------------------------------------DVVEELSLLR 1667
             .||       :.||||                                      :|.||    .
Human  1563 -AFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEE----N 1622

  Fly  1668 RGGLKNQQDTLR--------------------FSRCLVRAKLLKTRLALLRVLTHGELPC----- 1707
            .|.|||....:.                    .|.||.....:..|.:........::.|
Human  1623 DGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTD 1687

  Fly  1708 ----------------RRLFLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSD-- 1754
                            ||:::|:.|:.....:::  |.:......|:.::....:...:.|||
Human  1688 LLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLT--GLEPDAINVLIGSIRIDSLGTLSDLSDCE 1750

  Fly  1755 ----------SRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERI 1809
                      ||:|     ||         ....::...::..:...:.|.        |:.|
Human  1751 GRLFPIGYQCSRLY-----WS---------TVDARRRCWYRCRILEYRPWG--------PREE-- 1791

  Fly  1810 EQMKEHEREADRQQKHVHASTALEDQRERES---SNDRFRQDRFRRDTTSSRIGKPIRMSGNNTI 1871
               ..|...|:..|..||:.....:....|.   ..|........|.:....:..|:|
Human  1792 ---PAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLR------- 1846

  Fly  1872 CTITTQQKGSNGAPDGMTRNDNRRRSDIGPPSEQRRTLSKELRRSLFERKVALDEAERRVCTEDR 1936
                   ..|..||....|:.:..|..:...|..||.|
Human  1847 -------PDSGSAPPPAPRSFSGARIKVPNYSPSRRPL--------------------------- 1877

  Fly  1937 LEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKAL------------ 1989
                       ..::..|...|....:.|:......|...|||||.......|
Human  1878 -----------GGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASP 1931

  Fly  1990 ---------LSPDIDVGQGATDVEYKL-PPGVDPLPP 2016
                     :.|...|....|....:| |||..|.||
Human  1932 PLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPP 1968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	20/84 (24%)
		SET	1414..1533	CDD:214614	29/153 (19%)
		PostSET	1535..1551	CDD:214703	4/20 (20%)
		WW	2014..2043	CDD:278809	2/3 (67%)
		SRI	2270..2348	CDD:285448
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		16/62 (26%)
		Menin-binding motif (MBM). /evidence=ECO:0000269\|PubMed:22327296	17..36		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..302		46/241 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..518		60/267 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..771		81/401 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..868		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..959		20/95 (21%)
		zf-CXXC	958..1005	CDD:251032	11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1132		25/119 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1166		6/20 (30%)
		PHD1_KMT2B	1203..1249	CDD:277064	13/55 (24%)
		PHD2_KMT2B	1251..1300	CDD:277066	14/52 (27%)
		PHD3_KMT2B	1337..1393	CDD:277068	5/55 (9%)
		Bromo_ALL-1	1374..1516	CDD:99925	31/157 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1567		7/26 (27%)
		ePHD_KMT2B	1581..1685	CDD:277164	12/107 (11%)
		FYRN	1734..1780	CDD:283589	8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1978		35/215 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	2508..2513
		SET	<2559..2715	CDD:225491
		SET	2577..2697	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	2652..2653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840