Protein Alignment Set2 and SET1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1083
• Identity: 225/1083 - (20%)
• Similarity: 363/1083 - (33%)
• Gaps: 335/1083 - (30%)

  Fly   600 PPLKDESDPKQTEVELPESKPAVNIP-KSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSL 663
            |.:| .|||:.....:...|.|.:.. ::..||...:......|.||..|  |.|..|
Yeast   200 PEIK-ASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSC--EIVVYP------- 254

  Fly   664 STEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPN-------FLLEDYESNQEQVAEDE 721
             .::.:..|::...:|....|...   ....||.|   :||       :|:: |.|:..::
Yeast   255 -AQDSTTTNIQDISIKNYFKKYGE---ISHFEAFN---DPNSALPLHVYLIK-YASSDGKI---- 307

  Fly   722 MMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSS---------PAIVDKKVRAGEM 777
                              .:..|.....|.|.|        ||         ..|::|......:
Yeast   308 ------------------NDAAKAAFSAVRKHE--------SSGCFIMGFKFEVILNKHSILNNI 346

  Fly   778 EKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLD 842
            ..|.|:     :..||:.           |.:|:.|.|||    ||.|.||:.           :
Yeast   347 ISKFVE-----INVKKLQ-----------KLQENLKKAKE----KEAENEKAK-----------E 380

  Fly   843 KKGKD-TAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKA 906
            .:||| |....|::.||..||..  ::..|..:....:|:|.    .|.:|          :..|
Yeast   381 LQGKDITLPKEPKVDTLSHSSGS--EKRIPYDLLGVVNNRPV----LHVSK----------IFVA 429

  Fly   907 KEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSG 971
            |.:    |...|..:|......|:.                      ::.||.:.:
Yeast   430 KHR----FCVEDFKYKLRGYRCAKF----------------------IDHPTGIYI--------- 459

  Fly   972 KTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVK-KKINPRRSTICEAAKDLRSSSS 1035
                    ::.|..:.:..|:..|.:....:.:.:: |..:| ..|.||........|.  ||||
Yeast   460 --------IFNDIAHAQTCSNAESGNLTIMSRSRRI-PILIKFHLILPRFQNRTRFNKS--SSSS 513

  Fly  1036 SSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTI---CEDRQPETAIPVPLT 1097
            :||       :.|:...|........:|:...||:....:|.::..|   ..|.......|..|.
Yeast   514 NST-------NVPIKYESKEEFIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLA 571

  Fly  1098 KRRFSMHPK---ASANPLHDTLLQTAGKKRG----------RKEGKESLSRQNS--LDSSSSASQ 1147
            ||......|   .::....|.|.:....||.          .|..|.:|.|.||  ||.:|.
Yeast   572 KRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSL--- 633

  Fly  1148 GAPKKKALKSAEILSAALL--ETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNL 1210
               |:|.|.:.....|.||  ||:|.|:|                     |..|      :|:.
Yeast   634 ---KRKKLSNGIKPMAHLLNEETDSKETT---------------------PLND------EGIT- 667

  Fly  1211 LKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPS---------PTQSNPEDSA 1266
                :|.::..:|.::.....::.||:|...:....|:..|||...         |.|:...|..
Yeast   668 ----RVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVL 728

  Fly  1267 STTTVLKELETGGGVRRSHRIKQ---KPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQ 1328
            ..:::.|...|        .|.:   .|:.......:.::|:.|.....||:  ::..::.:...
Yeast   729 DASSMYKPTAT--------EIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEE--DMLILKQLLST 783

  Fly  1329 FLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTG---DEEAQGHLSCGAGCINRM---LM 1387
            :..:....|...|:...::..|:|.:|.........|.|   |.|.|...|..|....::   |.
Yeast   784 YTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLK 848

  Fly  1388 IECGP------------------------LC--------------------SNGARCTNKRFQQH 1408
            |...|                        ||                    |...|.:|:||||.
Yeast   849 INYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQD 913

  Fly  1409 QCWPCRVFRTEKKGCGITAELL-----------------------------IPPGEFIMEYVGEV 1444
                   ...:|...|..:|||                             |...|.|:|||||.
Yeast   914 -------IEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGER 971

  Fly  1445 IDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRI 1509
            |.....|.|:..|.|:.....|...:....|||||.||.|:|:|||.||||...:...|.|..||
Yeast   972 IRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRI 1036

  Fly  1510 GFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANCRGWI 1550
            ..::::.|...||:|:||::.|...|.:|  |.|.|.||:|::
Yeast  1037 VIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFL 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	25/131 (19%)
		AWS	1358..1410	CDD:197795	19/101 (19%)
		SET_SETD2	1410..1551	CDD:380949	54/172 (31%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550
		RRM_scSet1p_like	246..360	CDD:409743	27/176 (15%)
		SET_assoc	422..486	CDD:432058	13/116 (11%)
		N-SET	763..932	CDD:463344	32/177 (18%)
		SET_SET1	926..1076	CDD:380998	50/149 (34%)